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We present a report on INTESA's experiences with High Performance Computing in the Venezuelan Industry, with an emphasis on Oil and Gas. We will review the main challenge areas and their associated challenges that demand HPC techniques and technologies. We will look at problems within Seismic Processing and Interpretation, Reservoir modeling and integral reservoir management, and refining process development and modeling. We will describe the demands on high bandwidth I/O, parallel computing and high performance visualization, as well as the particular idiosyncrasies of HPC in a corporate environment.