1. Write the program 

R3 <- M[x3005]
R3 <- NOT R3
R3 <- R3 + 1
M[x3005] <- R3
HALT
                                           
2. specify start address
Binary           Hex  Assembly
0011000000000000 3000 .ORIG x3000

3. Code the instructions

Binary

0011000000000000
0010011000000100
1001011011111111
0001011011100001
0011011000000001
1111000000100101

Hex

3000
2604
96FF
16E1
3601
F025

Assembly

.ORIG x3000
LD  R3, #4
NOT R3, R3
ADD R3, R3, #1
ST  R3, #1
HALT
.END