Computer Sciences Dept.

Deborah Muganda

I am currently pursuing a Ph.D in Computer Sciences at the University of Wisconsin-Madison with a focus in Bioinformatics and Artificial Intelligence. I am in Mark Craven's research group. I graduated with a Bachelor of Sciences in Biochemistry and minor in Math from North Central College in Naperville IL.

Research Interests
I am interested in the task of aligning and comparing gene-expression time series. We are developing methods to determine which sets of genes have a similar expression patterns across multiple biological conditions.

Deborah in Tanzania summer 2009
Computer Sciences Course Work:

Current Research Project
My research group has previously developed an approach for aligning time series that computes clustered alignments. This method finds clusters of genes such that the genes within a cluster share a common alignment, but each cluster is aligned independently of the others. We are now extending this method in various ways. First, we examine ways of incorporating into our approach a method for determining which genes are actually differentially expressed over the biological conditions. Secondly, we seek to identify genes that are expressed in a non-correlated fashion across the biological conditions and therefore may be difficult to align. Finally, we are exploring ways of improving our clustered alignments by adding background knowledge about pathways and cellular processes to the models.

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