M. Craven & J. Shavlik (1993).
Learning to Predict Reading Frames in E . coli DNA Sequences. Proceedings of the 26th Hawaii International Conference on System Sciences, pp. 773-782, Wailea, HI. IEEE Computer Society Press.
This publication is available in PDF and available in postscript.
The data associated with this publication is available online.
Two fundamental problems in analyzing DNA sequences are (1) locating the regions of a DNA sequence that encode proteins, and (2) determining the reading frame for each region. We investigate using artificial neural networks (ANNs) to find coding regions, determine reading frames, and detect frameshift errors in E. coli DNA sequences. We describe our adaptation of the approach used by Uberbacher and Mural to identify coding regions in human DNA, and we compare the performance of ANNs to several conventional methods for predicting reading frames. Our experiments demonstrate that ANNs can outperform these conventional approaches.
Computer Sciences Department
College of Letters and Science
University of Wisconsin - Madison
INFORMATION ~ PEOPLE ~ GRADS ~ UNDERGRADS ~ RESEARCH ~ RESOURCES
5355a Computer Sciences and Statistics ~ 1210 West Dayton Street, Madison, WI 53706
firstname.lastname@example.org ~ voice: 608-262-1204 ~ fax: 608-262-9777