M. Craven, D. Page, J. Shavlik, J. Bockhorst & J. Glasner (2000).
Probabilistic Learning Approach to Whole-Genome Operon Prediction. Proceedings of the Eighth International Conference on Intelligent Systems for Molecular Biology, La Jolla, CA.
This publication is available in PDF and available in postscript.
We present a computational approach to predicting operons in the genomes of prokaryotic organisms. Our approach uses machine learning methods to induce predictive models for this task from a rich variety of data types including sequence data, gene expression data, and functional annotations associated with genes. We use multiple learned models that individually predict promoters, terminators and operons themselves. A key part of our approach is a dynamic programming method that uses our predictions to map every known and putative gene in a given genome into its most probable operon. We evaluate our approach using data from the E. coli K-12 genome.
Computer Sciences Department
College of Letters and Science
University of Wisconsin - Madison
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