health care founded 1993 headquarters fremont california united states nes ziona israel key people philip b. simon chairman daniel zurr ceo rami skaliter coo number of employees 70 2006 website www.quarkpharma.com quark pharmaceuticals is a pharmaceutical company that develops rna interference based treatments for chronic and acute diseases . 1 the company uses state of the art rna interference technology to develop sirnas which inhibit targeted genes from producing proteins associated with certain diseases . two products are reported to be in phase iii clinical trials qpi 1002 for delayed graft function 2 and qpi 1007 for acute non arteritic anterior ischemic optic neuropathy naion . 3 history highlights edit establishes a chinese joint venture with suzhuo and raises rmb 45 million for the joint venture . the jv will develop qpi 1007 for china and other markets . 4 enters into a license and collaboration agreement with biocon ltd. to develop qpi 1007 for india and other key markets . 5 reports results for pf 655 formerly pf 04523655 or rtp801i 14 from a phase ii trial in patients with diabetic macular edema . 6 enters into a licensing option agreement with novartis to obtain exclusive worldwide rights to qpi 1002 . 7 closes 27 million financing with sbi holdings inc. of japan . 8 in august 2007 medical news today announced that quark obtained positive preclinical results of systemic rnai compound for acute renal failure arf . the study showed that rats that were treated with the injection of quark s sirna akii 5 which inhibits the gene p53 where significantly protected from ischemia reperfusion induced acute kidney injury compared to the ones that were not treated . the result showed a favorable safety profile for the drug with a therapeutic index in rats greater than 250 . 9 quark pharmaceutical signed a collaboration agreement with the university of michigan for the development of proprietary sirna for noise induced hearing loss . the collaboration includes studies on different sirna candidate drugs inhibiting quark s proprietary target genes for the prevention and treatment of hearing loss caused by acoustic trauma . the studies will assess delivery efficacy of sirna compounds to cochlear cells in the inner ear . 10 11 quark and pfizer signed a collaboration agreement where quark granted pfizer the rights to develop and commercialize drug candidates that inhibit quark s target gene rtp801 through rnai . 12 since 2005 quark also holds a collaboration with the center for hearing & deafness of the university of new york at buffalo . the focus of the collaboration is to analyze the effect of quark s sirna drug candidate in preventing chemotherapy induced hearing loss . 13 in 2005 quark licensed the phase ii of compound bt16 to sanwa for the treatment of dyslipidemia . 14 in 2004 peer reviewed journal oncogene reported that quark discovered the role of gene ero 1l alpha in protein secretion under hypoxic condition . this finding suggested that by inhibiting this gene a therapeutic effect could be obtained in the treatment of cancer and other pathologies involving hypoxia . 15 in 2001 mitsubishi pharmaceutical corp sankyo co fujisawa presently astellas and taisho pharmaceutical co. ltd. of japan each made an equity investment in quark . citation needed from 1995 to 2004 quark established collaborations with mitsubishi pharmaceutical corp. sankyo co. taisho pharmaceutical . ltd. astrazeneca astellas pharma inc. and shionogi & co. ltd. for quark s bifar technology platform to discover new target genes for drug development . 16 in 1999 the prestigious magazine science published the discovery of the concept of temporary and reversible inhibition of the p53 gene for therapeutic pursposes discovered by scientists from university of illinois chicago and quark . 10 september 1999 vol 285 science . notes edit google finance info for quark pharmaceuticals https clinicaltrials.gov ct2 show nct02610296 https clinicaltrials.gov ct2 show nct02341560 http www.chinabiotoday.com articles 20140111 print http www.thepharmaletter.com article biocon and quark pharma collaborate on novel sirna based therapeutics http www.reviewofoptometry.com newsletter op optometric physician march 28 2011 briefs http www.firstwordpharma.com node 743395 tsid 17 axzz45v7kf9tl http www.dailycamera.com ci 13140072 quark pharmaceuticals inc. presented positive preclinical results of systemic rnai compound for acute renal failure arf lifesciencesworld quark pharmaceuticals signs collaboration agreement with university of michigan for development of proprietary sirna compounds for noise induced hearing loss news quark pharmaceuticals inks a deal to advance preclinical pipeline of hearing loss compounds . genetic engineering & biotechnology news biotechnology from bench to business http www.pharmsource.com wp content downloads periscope pharmsource periscope may 2007.pdf quark pharmaceuticals extends research agreement with state university of new york for proprietary sirna compounds for acute hearing loss quark pharmaceuticals quark biotech discovers role of ero 1l alpha gene in cancer involvement in protein secretion under hypoxic conditions pharmsource pharmsource periscope may 2007 issue permanent dead link external links edit www.quarkpharma.com quark pharmaceuticals corporate website v t e pharmaceutical companies of the united states abbott laboratories acorda therapeutics actavis aderis pharmaceuticals adolor corporation alcon alexion pharmaceuticals alkermes allergan alza amgen amylin pharmaceuticals ariad pharmaceuticals aryx therapeutics avax technologies baxter international biocryst pharmaceuticals biogen biolex biovest biovista bradley pharmaceuticals bristol myers squibb cancervax century pharmaceuticals cephalon ceragenix pharmaceuticals combe incorporated cortex pharmaceuticals cotherix covance covidien cubist pharmaceuticals cutter laboratories cytosport cytrx danco laboratories dnaprint genomics epix pharmaceuticals eli lilly and company elorac endo pharmaceuticals ethicon endo surgery ethicon inc. forest laboratories galena biopharma genvec genentech genta gilead sciences hospira imclone systems institute for oneworld health intercept pharmaceuticals ista pharmaceuticals ivax corporation janssen biotech johnson & johnson kinetic concepts king pharmaceuticals kinray kv pharmaceutical leiner health products mallinckrodt martek biosciences corporation s. e. massengill company mckesson corporation mcneil laboratories melior discovery mentholatum merck & co. miles laboratories mylan myriad genetics naurex nereus pharmaceuticals northwest biotherapeutics norwich pharma services novabay pharmaceuticals nuvelo organon international ortho pharmaceutical ortho mcneil pharmaceutical osi pharmaceuticals ovation pharmaceuticals par pharmaceutical parke davis perrigo pfizer pharmaceutical product development prasco laboratories procter & gamble proteon therapeutics purdue pharma qualitest quark pharmaceuticals regeneron repros therapeutics rib x pharmaceuticals sarepta therapeutics savage laboratories schering plough g. d. searle & company sheffield pharmaceuticals smith kline & french spectrum pharmaceuticals sterling drug tanox tap pharmaceutical products tec laboratories teva pharmaceutical industries tiens biotech group titan pharmaceuticals trevena inc trubion upjohn upsher smith laboratories valeant pharmaceuticals ventria bioscience vertex pharmaceuticals verus pharmaceuticals vion pharmaceuticals inc. viropharma west pharmaceutical services wyeth zonite products corporation list of pharmaceutical companies retrieved from https en.wikipedia.org w index.php title quark pharmaceuticals & oldid 730988182 categories pharmaceutical companies of the united statespharmaceutical companies of israelbiotechnology companies of the united statescompanies based in fremont californiapharmaceutical companies established in 19931993 establishments in californiatechnology companies based in the san francisco bay areahidden categories all articles with dead external linksarticles with dead external links from july 2016articles with permanently dead external linksall articles with unsourced statementsarticles with unsourced statements from july 2014 navigation menu personal tools not logged intalkcontributionscreate accountlog in namespaces article talk variants views read edit view history more search navigation main pagecontentsfeatured contentcurrent eventsrandom articledonate to wikipediawikipedia store interaction helpabout wikipediacommunity portalrecent changescontact page tools what links hererelated changesupload filespecial pagespermanent linkpage informationwikidata itemcite this page print export create a bookdownload as pdfprintable version languages add links this page was last modified on 22 july 2016 at 05 00 . text is available under the creative commons attribution sharealike license ; additional terms may apply . by using this site you agree to 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