industry pharmaceuticals natural products ingredients founded 1999 headquarters irvine california united states key people frank jaksch co founder ceo products pteropure niagen nicotinamide riboside purenergy proc3g website chromadex.com chromadex is a publicly traded natural products company based in irvine california . the company is most well known for its industry standard phytochemical testing laboratories and catalogue . in cooperation with the university of mississippi the company is currently exploring the effects of pterostiibene on humans . 1 chromadex has licensed patents from the university of mississippi and the usda to commercially develop pterostilbene and sell the compound trademarked as pteropure via the company s bluscience product line . 2 in 2010 chromadex won the north american frost & sullivan award for most promising ingredient of the year for pteropure pterostilbene . 3 in 2016 chromadex achieved gras status for its patented nicotinamide riboside product niagen which allows it to be marketed in the food and beverage industries . 4 chromadex also initiated a 2nd human clinical trial on niagen to examine the benefits if taken daily for eight consecutive weeks . 5 in addition chromadex was named as part of the otcqx best 50 . 6 american billionaire and pharmaceutical entrepreneur phillip frost owns approximately 19 % of chromadex . 7 8 contents 1 early history 2 chromadex catalogue 3 pteropure 4 niagen & nicotinamide riboside technology 5 contract research services & capabilities 6 see also 7 references 8 external links early history edit chromadex was founded in 1999 . according to a standard & poor s research report the company was created in response to growing demand for natural product reference standards materials and services . it has worked to establish itself as an industry leader in nutraceutical and botanical certification and even publishes its own manual outlining specifications for phytochemicals . on july 14 2008 chromadex merged with cdi acquisition a subsidiary of cody resources inc. on july 29 2008 the company completed a private placement agreement which yielded gross proceeds of 4.67 million . 9 later in 2008 chromadex otcqx cdxc became a publicly traded company . shares of chromadex are traded on the otc markets qx marketplace . as of april 2015 there were 108 million shares outstanding . 10 chromadex catalogue edit the chromadex catalogue provides phytochemical reference standards botanical reference materials and research grade materials for the natural products industry . the company sells over 3 000 phytochemicals and 470 botanical reference materials in its catalogue . the company s products reach a wide range of markets including food & beverage pharmaceutical cosmeceutical research organizations and governmental groups . pteropure edit chromadex received exclusive worldwide patent rights for its pteropure pterostilbene product based on the technology licensed from the university of mississippi and the usda . pterostilbene belongs to a class of compounds called phytoalexins which are antimicrobial substances synthesized de novo by plants that accumulate rapidly at areas of incompatible pathogen infection . pterostilbene and resveratrol have similar pharmacologic properties . however pterostilbene has exhibited advantages over resveratrol including superior biological activity better oral bioavailability and a slower metabolizing time which provides more time for the compound s antioxidant activities to act . 11 12 13 according to the usda pterostilbene is one of many aromatic hydrocarbons called stilbenes . chromadex s pteropure is an identical form of trans pterostilbene . the university of california irvine is currently studying pteropure for its efficacy as a treatment for melanomas and other skin cancers when used in a skincare product . 14 niagen & nicotinamide riboside technology edit on july 13 2011 cornell university announced it granted chromadex exclusive worldwide rights to a novel manufacturing process for nicotinamide riboside nr . nr a vitamin found in milk is a more potent version of niacin vitamin b3 . like niacin nr is a precursor to nicotinamide adenine dinucleotide nad which is elevated by a calorie restricted diet . increasing cellular nad has demonstrated cell protective and positive metabolic effects . in laboratory tests nr has shown promise for improving cardiovascular health glucose levels and cognitive function and has demonstrated evidence of anti ageing effects . 15 16 chromadex markets and sells nicotinamide riboside as an ingredient under the brand name niagen . in 2015 chromadex announced the results of its first clinical study stating niagen nicotinamide riboside effectively increases the co enzyme nad and is safe . 17 in 2016 chromadex initiated a second human clinical trial on niagen a randomized double blind placebo controlled parallel study in 140 healthy adults ranging in age from 40 60 to examine the benefits if taken daily for eight consecutive weeks 5 contract research services & capabilities edit chromadex also offers contract research services that help customers source raw materials identify new compounds and develop processes for large scale manufacturing . the company also has a number of analytical capabilities including gas chromatography mass spectrometry near infrared spectroscopy and high performance liquid chromatography . 10 see also edit phillip frost pterostilbene resveratrol nicotinamide riboside references edit standard & poor s 2013 10 05 . chromadex standard & poor s factual report . standard & poors . p. 10 . retrieved 2013 10 10 . neeb matthew 2011 06 20 . ole miss grants exclusive patent rights to chromadex corp. . the daily mississippian . retrieved 2012 05 25 . frost & sullivan recognizes chromadex for the unique potential its commercially available product offers in the human nutrition industry . yahoo finance . 5 3 2011 . retrieved 2012 05 25 . check date values in date help chromadex lead ingredient niagen nicotinamide riboside achieves gras status . thestreet . retrieved 2016 03 22 . a b inc. chromadex . chromadex initiates second human clinical study on niagen the world s first and only commercially available form of nicotinamide riboside nr . globenewswire news room . retrieved 2016 03 22 . otc markets group announces the 2016 otcqx best 50 otcmarkets.com . www.otcmarkets.com . retrieved 2016 03 21 . gould david 5 3 2011 . billionaire phillip frost a case study in synergy . trefis . retrieved 2012 05 29 . check date values in date help chromadex corp. names consumer products veteran jeffrey himmel ceo . 2012 1 23 . retrieved 2012 05 29 . check date values in date help functional ingredients . 5 10 2009 . retrieved 2012 05 29 . check date values in date help a b otc markets stock profile cdxc . otc markets . retrieved 2016 03 21 . im kapetanovic ; et al. november 2010 . pharmacokinetics oral bioavailability and metabolic profile of resveratrol and its dimethylether analog pterostilbene in rats . cancer chemother pharmacol . 68 3 593 601 . doi 10.1007 s00280 010 1525 4 . pmc 3090701 . pmid 21116625 . cm remsberg ; et al. february 2008 . pharmacometrics of pterostilbene preclinical pharmacokinetics and metabolism anticancer antiinflammatory antioxidant and analgesic activity . phytother res . 22 2 169 79 . doi 10.1002 ptr .2277 . pmid 17726731 . p ferrer ; et al. january 2005 . association between pterostilbene and quercetin inhibits metastatic activity of b16 melanoma . neoplasia . 7 1 37 47 . doi 10.1593 neo .04337 . pmc 1490314 . pmid 15736313 . best of 2011 ingredient supplier chromadex . nutritional outlook . retrieved 2012 05 29 . got nicotinamide riboside . life extension . 2007 05 04 . retrieved 2012 05 29 . belenky p ; bogan kl ; brenner c 2007 . nad metabolism in health and disease pdf . trends biochem . sci . 32 1 12 9 . doi 10.1016 j.tibs .2006.11.006 . pmid 17161604 . retrieved 2007 12 23 . inc. chromadex . results from first human clinical study demonstrate chromadex s niagen r nicotinamide riboside effectively increases the co enzyme nad and is safe . globenewswire news room . retrieved 2016 03 21 . external links edit chromadex website results from first human clinical study demonstrate chromadex s niagen r nicotinamide riboside effectively increases the co enzyme nad and is safe effect of pterostilbene on cholesterol blood pressure and oxidative stress retrieved from https en.wikipedia.org w index.php title chromadex & oldid 719292504 categories biotechnology companies of the united statespharmaceutical companies of the united statespharmaceutical companies established in 1999companies based in irvine californiahidden categories cs1 errors dates navigation menu personal tools not logged intalkcontributionscreate accountlog in namespaces article talk variants views read edit view history more search navigation main pagecontentsfeatured contentcurrent eventsrandom articledonate to 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