an advertisement . please help improve it by removing promotional content and inappropriate external links and by adding encyclopedic content written from a neutral point of view . november 2014 learn how and when to remove this template message a major contributor to this article appears to have a close connection with its subject . it may require cleanup to comply with wikipedia s content policies particularly neutral point of view . please discuss further on the talk page . november 2014 learn how and when to remove this template message codexis inc. type public traded as nasdaq cdxs industry biocatalysis pharmaceuticals industrial biotechnology fine chemicals biobased chemicals founded 2002 headquarters redwood city ca u.s. key people john j. nicols chief executive officer ceo and president jim lalonde vice president research and development gordon sangster chief financial officer cfo revenue us 33 35 million fy 2013 number of employees 88 as of april 2014 1 website codexis inc. codexis inc. engineers enzymes for pharmaceutical and chemical production . codexis technologies enable scale up and implementation of biocatalytic solutions to optimize process development from research to manufacturing . there are currently over 50 pharmaceutical firms using codexis technology products and services in their manufacturing process development . codexis creates its products by applying its codeevolver directed evolution technology platform which introduces genetic mutations into microorganisms . contents 1 pharmaceutical enzymes intermediates and services 2 codex biocatalyst panels and kits 3 enzyme screening services 4 enzymes 5 intermediates and apis 6 technology 6.1 chemicals 6.2 operations 7 history 8 external links 9 references pharmaceutical enzymes intermediates and services edit codexis markets and sells enzymes development services and screening tools providing manufacturing processes for active pharmaceutical ingredients apis and their precursor pharmaceutical intermediates . codexis customers include major companies such as merck pfizer and teva that use codexis custom biocatalysts to create more sustainable less costly manufacturing processes for new and existing drugs . codexis biocatalysts are being used in the manufacturing process for the cholesterol fighting drug lipitor and are in development for the manufacturing of the diabetes drug januvia . codexis won the presidential green chemistry challenge award from the u.s. environmental protection agency epa in 2006 for its work on a building block of lipitor 2 and a second time with merck in 2010 for its work on the active ingredient in januvia . 3 codex biocatalyst panels and kits edit codexis sells codex biocatalyst panels and kits to companies who are engaged in both drug development and the marketing of approved drugs to allow them to screen and identify possible enzymatic manufacturing processes for their drug candidates and their marketed products . codex biocatalyst panels determine whether an enzyme produces a desired activity that is applicable to a particular process . 4 for compounds that are in development codex biocatalyst panels and kits allow innovators to screen and identify possible enzymatic manufacturing processes rapidly and inexpensively for many of their drug candidates in house without the risks of disclosing the composition of their proprietary molecules before they have received patent protection . they also generate data that codexis can use to optimize enzymes rapidly for a particular reaction if necessary reducing the time required to generate a manufacturing process capable of supporting clinical trials with inexpensively produced pure drugs . enzyme screening services edit customers can send codexis their materials to test against codexis existing libraries of enzymes . if codexis detects desired activity in a specific enzyme it can supply the customer with this enzyme or perform optimization services to improve the performance of the enzyme . 5 enzymes edit codexis supplies varying quantities of its enzymes to pharmaceutical companies from small to moderate quantities while they are optimizing their production processes to larger quantities during later stage clinical development and commercial scale drug production . 6 codexis also provides enzyme optimization services . 7 intermediates and apis edit codexis supply intermediates and apis made using enzymes . technology edit codexis engineers custom enzymes and microorganisms which are sometimes referred to as biocatalysts . in simple terms codexis enzymes and microorganisms initiate or accelerate chemical reactions . codexis proprietary technology called codeevolver is directed evolution technology . it is based on the concept that natural genetic mutation and selection can be accelerated in the research laboratory to obtain specific improvements in the function of single proteins and multiprotein pathways . codeevolver combines dna shuffling and bioinformatics with systems biology to create new biocatalysts . willem p.c. stemmer the inventor of dna shuffling technology upon which codexis was founded and frances h. arnold received the national academy of engineering s charles stark draper prize for their individual work on directed evolution technology . 8 chemicals edit codexis is using its work in biofuels to develop sustainable sources for the 2 million ton detergent alcohol market . 9 detergent alcohols go into household products such as shampoo and conditioner . approximately 70 % of detergent alcohols are derived from palm kernel oil . the remaining 30 % is derived from petroleum . the rising price and price volatility of palm oil and crude oil combined with environmental concerns have prompted consumer product companies to seek out sustainable alternatives . 10 operations edit codexis corporate headquarters is located in redwood city california and provides general administrative support to its business and is the center of codexis manufacturing and research and development operations . history edit based in redwood city ca codexis was incorporated in 2002 . the company went public in april 2010 on nasdaq under the ticker symbol nasdaq cdxs . external links edit official web site references edit codexis overview . retrieved 2011 04 03 . http ir.codexis.com phoenix.zhtml c 208899 & p irol newsarticle & id 1181061 http www.reuters.com article 2010 06 17 merck green idusn1727061820100617 http www.codexis.com screening tools http www.codexis.com screening evolution http www.codexis.com codexis products http www.chemanager online.com en topics chemicals distribution codexis sees success pharma business page 1 atkins randy january 4 2011 . directed evolution pioneer in dna sequencing and designer of curricular program win honors . national academy of sciences . codexis enters detergent alcohols market . retrieved 2011 03 04 . steenhuysen julie june 17 2010 . greener approach to januvia cuts costs ups yield . reuters . http ir.codexis.com phoenix.zhtml c 208899 & p irol newsarticle & id 1181061 http www.reuters.com article 2010 06 17 merck green idusn1727061820100617 http www.codexis.com screening tools http www.codexis.com screening evolution http www.codexis.com codexis products http www.chemanager online.com en topics chemicals distribution codexis sees success pharma business page 1 http www.eurekalert.org pub releases 2011 01 naos ep010411.php http www.icis.com blogs green chemicals 2011 03 codexis enters detergent alcoh.html http www.reuters.com article 2010 06 17 merck green idusn1727061820100617 http www.codexis.com what is biocatalysis retrieved from https en.wikipedia.org w index.php title codexis & oldid 735756947 categories biotechnology companies of the united statescompanies listed on nasdaqhidden categories articles with a promotional tone from november 2014all articles with a promotional tonewikipedia articles with possible conflicts of interest from november 2014 navigation 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