industry clinical research organizations pharmaceutical founded 1982 headquarters waltham massachusetts united states of america ; 80 facilities in 51 countries key people chairman and ceo josef h. von rickenbach services clinical trial management data management medical writing biostatistics pharmacovigilance regulatory consulting revenue 2.016 b for fy15 number of employees 18 660 1 website 1 parexel international is a multinational life sciences consulting firm . it conducts clinical trials on behalf of its pharmaceutical clients to expedite the drug approval process . it is the second largest clinical research organization in the world 2 and has helped develop approximately 95 % of the 200 top selling biopharmaceuticals on the market today . 3 the company publishes the annual parexel r & d statistical sourcebook 4 operates the parexel academy 5 and councils all of the top 50 biopharmaceutical and top 30 biotechnology companies . 6 parexel was founded in 1982 by josef von rickenbach 7 and organic chemist anne b. sayigh 8 initially to advise japanese and german firms on how to navigate the fda approval process . 9 the firm has grown organically over the years and through 40 acquisitions . josef von rickenbach is credited with establishing parexel s culture and practices based on the principles he experienced as a researcher at schering plough in lucerne switzerland . 9 in 1990 the firm expanded internationally and established new practice areas . by 1999 it had a staff of 4 500 and 45 offices . 9 in the 2000s it grew to over 18 000 employees . parexel s consulting and clinical trial work has helped establish many household drug brands and contributed to numerous successes in modern pharmacology . in 2016 the company allied with emc corporation to provide a suite of regulated information and content management services . 10 contents 1 tgn1412 clinical trial 2 see also 3 references 4 external links tgn1412 clinical trial edit main article tgn1412 the neutrality of this section is disputed . relevant discussion may be found on the talk page . please do not remove this message until conditions to do so are met . august 2015 learn how and when to remove this template message in march 2006 a parexel run trial on behalf of tegenero the now bankrupt german biotechnology firm on its anti inflammatory drug tgn1412 to treat rheumatoid arthritis multiple sclerosis or leukaemia unexpectedly caused severe inflammation and multiple organ failure in six healthy volunteers at a facility based at northwick park hospital in london . 11 the drug had been tested on animals but this was the first test on humans . parexel became the target of legal proceedings from lawyers representing the injured volunteers after the insurance policy of tegenero was unable to provide sufficient compensation . when the liable company 12 subsequently declared bankruptcy 13 lawyers for the volunteers initiated legal proceeding against parexel and the two parties later entered into talks ; 14 the results of this meeting have not been made public . 15 a documentary shown in the uk on 28 september 2006 featuring journalist brian deer as part of channel 4 s dispatches series exposed uncertainty about the existence of data that should mandatorily have been submitted by tegenero to the medicines and healthcare products regulatory agency mhra prior to the trial indicating whether tgn1412 had been adequately tested on human blood in vitro . concerns were also raised about whether a safe human dosage was properly obtained by tegenero . the mhra however concluded that none of the companies involved could be held responsible for the outcome of the test and that the adverse events that occurred were most likely caused by an unpredicted biological action of the drug in humans . 16 see also edit inventiv health inc cytel references edit parexel international number of employees prxl nasdaq . macroaxis . top cros dominate competition in trial totals review finds . outsourcing pharma.com . moneyshow.com top pros top picks parexel puts drugs on trial . moneyshow.com . parexel biopharmaceutical statistical sourcebook 2014 2015 estats . applied clinical trials editorial staff 13 april 2015 . parexel academy adds programs for students . http phx.corporate ir.net external.file item ugfyzw50suq9mjqwndc3fenoawxksuq9ltf8vhlwzt0z & t 1 list of public companies worldwide letter businessweek businessweek . businessweek.com . http www.the scientist.com articles.view articleno 9750 title entrepreneur briefs a b c josef von rickenbach parexel . bilanz.ch . staff 15 may 2016 . parexel and emc ally to provide information management services . genetic engineering & biotechnolgy news paper . 36 10 8 . drugs trial men seriously ill . bbc news . march 15 2006 . when drug trials go horribly wrong . the international herald tribune . april 9 2006 . retrieved 2007 12 18 . will parexel settle tegenero litigation . clinpage . march 19 2007 . retrieved 2007 12 18 . window is open for compensation in tgn1412 case . pharmatimes . march 14 2007 . retrieved 2007 12 18 . parexel issues statement regarding tegenero clinical trial . clinical trial final report mhra 25 may 2006 external links edit parexel international retrieved from https en.wikipedia.org w index.php title parexel & oldid 741805496 categories biotechnology companiescompanies based in massachusettscontract research organizationscompanies listed on nasdaqbiotechnology companies of the united statespharmaceutical companies of the united stateshidden categories pages using infobox company with unsupported parametersnpov disputes from august 2015all npov disputes navigation menu personal tools not logged intalkcontributionscreate accountlog in namespaces article talk variants views read edit view history more search navigation main pagecontentsfeatured contentcurrent eventsrandom articledonate to wikipediawikipedia store interaction helpabout wikipediacommunity portalrecent changescontact page tools what links hererelated changesupload filespecial pagespermanent linkpage informationwikidata itemcite this page print export create a bookdownload as pdfprintable version languages deutschesperantofran aissvenska edit links this page was last modified on 29 september 2016 at 19 48 . text is available under the creative commons attribution sharealike license ; 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