engineering founded 1989 headquarters mississauga ontario canada key people george q. w. yeh president products biopharmaceuticals immunodiagnostic products website www.anogen.ca anogen is the trade name of yes biotech laboratories ltd. a canadian biopharmaceutical company based in mississauga ontario . founded in 1989 anogen yes biotech specializes in developing and manufacturing monoclonal antibodies recombinant proteins synthetic bioactive peptides and enzyme linked immunosorbent assay elisa kits for research as well as diagnostic and therapeutic use . 1 it is also committed to seeking medical treatment of cancer autoimmune inflammatory and cardiovascular diseases by developing antibody based biopharmaceuticals . 2 3 4 5 6 it has an office in orlando united states and two research facilities in china one in xuzhou and another in shanghai . 7 contents 1 biopharmaceutical developments 1.1 psoriasis 1.2 cardiovascular diseases 1.3 alzheimer s disease 1.4 inflammatory diseases 2 references 3 external links biopharmaceutical developments edit psoriasis edit the company has developed a proprietary technology for topical antibody treatment of various skin conditions . 6 in early 1999 abcream the topical treatment of psoriasis and eczema with anti interleukin 8 neutralizing antibody completed a double blinded placebo controlled phase ii iii clinical trials . in these studies 49 % to 53.8 % of patients achieved a 60 % improvement and 12.9 % to 15.3 % of patients achieved a 90 % improvement in psoriasis area severity index pasi score after a six week treatment cycle with abcream . 8 in 2002 1452 patients with psoriasis vulgaris had completed for the phase iv clinical trail . of 61.91 % patients achieved a 60 % improvement and 17.85 % of patients achieved a 90 % improvement in pasi score after an eight week treatment cycle with abcream . no significant side effect of any kind was observed during and after the treatment . 9 abcream registered as enboke in china has been approved by state food and drug administration sfda of china for the treatment of psoriasis and eczema in 2003 . 10 cardiovascular diseases edit it has also developed a monoclonal antibody r813 to human platelet surface glycoprotein iiia . the phase i clinical trial has been completed that this antibody effectively inhibits the aggregation of human platelet with less hemorrhagic risk . both in vitro and in vivo studies suggest its therapeutic potential for treatment of cardiovascular diseases . 11 alzheimer s disease edit three anti a 42 monoclonal antibodies xuzhou 1 2 and 3 have been developed in 2011 for early detection and treatment of alzheimer s disease . 5 the clinical trials are planned to be completed within two years . 12 inflammatory diseases edit the company has begun to develop anti inflammatory therapy with humanized neutralizing monoclonal antibodies to chemokines . 4 references edit industry canada canada s life sciences exporters http www.ic.gc.ca app ccc srch nvgt.do lang eng & prtl 1 & sbprtl & estblmntno 123456267864 & profile cmpltprfl & profileid 984 & app sold shi wk ; ye qw ; bao lp 1993 . biological characterization of a monoclonal antibody tb 21 against human transforming growth factor beta 1 . shi yan sheng wu xue bao . 26 2 141 50 . pmid 8237223 . zhu zy ; zhong cp ; xu wf ; lin gm ; ye gq ; ji yy ; sun b ; yeh m 1999 . psma mimotope isolated from phage displayed peptide library can induce psma specific immune response . cell research . 9 4 271 80 . doi 10.1038 sj.cr .7290026 . pmid 10628836 . a b bao zhiyao ; ye qingwei ; gong wanghua ; xiang yi ; wan huanying 2010 . humanized monoclonal antibody against the chemokine cxcl 8 il 8 effectively prevents acute lung injury . international immunopharmacology . 10 2 259 63 . doi 10.1016 j.intimp .2009.11.005 . pmid 19909826 . a b xuzhou television . therapeutic monoclonal antibody developed in xuzhou china for treatment of alzheimer s disease . . retrieved 2011 04 14 . a b topical treatment of psoriasis using neutralizing antibodies to il 8 asia pacific foundation of canada . yes biotech laboratories opens manufacturing facility in china . retrieved 2011 04 14 . huang zuo . 2002 . en bo ke zhi liao yin xie bing de xin ji yuan . china prescription drug 5 54 6 1 liu xiao ming yang guo ling gao ming yang yang chun mei tan xue jing hou su chun yu xiao hong . 2003 . en bo ke ru gao zhi liao xun chang xing yin xie bing 172 li lin chuang guan cha . chinese journal of dermatovenerology of integrated traditional and western medicine 4 252 3 2 sfda registered medicine s20030093 monoclonal antibodies recognizing human platelet membrane glycoproteins and use thereof in anti thrombotic therapy 3 xuzhou daily . therapeutic monoclonal antibody for early detection and treatment of alzheimer s disease approved by chinese academy of sciences . . retrieved 2011 04 18 . external links edit official website yes biotech laboratories ltd. china website retrieved from https en.wikipedia.org w index.php title anogen & oldid 744412079 categories biotechnology companies of canadapharmaceutical companies of canadapharmaceutical companies established in 1989companies based in mississaugahidden categories official website different in wikidata and wikipedia navigation menu personal tools not logged intalkcontributionscreate accountlog in namespaces article talk variants views read edit view history more search navigation main pagecontentsfeatured contentcurrent eventsrandom articledonate to wikipediawikipedia store interaction helpabout wikipediacommunity portalrecent changescontact page tools what links hererelated changesupload filespecial pagespermanent linkpage informationwikidata itemcite this page print export create a bookdownload as pdfprintable version languages add links this page was last modified on 15 october 2016 at 01 45 . text is available under the creative commons attribution sharealike license ; 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