e c. s.a. type sociedade an nima industry major drugs health care founded april 19 1924 headquarters trofa portugal key people lu s portela ceo products pharmaceuticals number of employees 650 2009 website www.bial.com bial portela e c. s.a. is a pharmaceutical company headquartered in sao mamede do coronado in trofa porto district portugal . it was founded in 1924 being among the largest companies of its kind in portugal . bial is an international pharmaceutical group when . its products are sold in pharmacies in more than 40 countries in 4 continents europe america africa and asia . some of the group companies are laborat rios bial medibial bialfar bialport bial aristegui medimport and medangol . contents 1 financing 2 research and products 3 references 4 external links financing edit on 21 september 2015 the european investment bank signed a eur 45 million financing agreement for bial s r & d over the next 3 years . it was directed to discover develop and provide therapeutic solutions in ... three major areas of research central nervous system cns cardiology and allergen immunotherapy . the eib found bial not to have the status of a contracting entity and therefore bial has not been subject to eu rules on public procurement . 1 research and products edit in 2008 bial completed clinical evaluation of eslicarbazepine acetate a drug for the adjunctive use in partial seizures in adults with epilepsy . the japanese company eisai gained the sole license to market promote and distribute it as zebinix or exalief in europe . 2 in america it is marketed by sunovion under the name aptiom . 3 its use in epilepsy treatment in children is under development . a clinical trial of eslicarbazepine acetate as therapy in persons with diabetic neuropathic pain was prematurely halted . 4 etamicastat bia 5 453 is a dopamine hydroxylase inhibitor decreasing norepinephrine levels in peripheral sympathetically innervated tissues without effect in brain tissues of spontaneously hypertensive rats . 5 bia 5 1058 is another reversible dopamine beta hydroxylase inhibitor which decreases norepinephrine levels in peripheral sympathetically innervated tissues without cns effects . 6 opicapone bia 9 1067 bial s second pharmaceutical is a comt inhibitor for the treatment of parkinson disease 7 it is under review by the european medicines agency ema . on 9 september 2015 bial entered into an agreement with helsinn for the exclusive distribution and license rights to helsinn s drug anamorelin in spain portugal angola and mozambique . 8 in 2015 bial commissioned a contract research organization biotrial to run a phase one clinical trial for bia 10 2474 an faah inhibitor 9 that targets the endocannabinoid system . 10 the research in rennes commenced in july 2015 evaluating male and female subjects aged between 18 and 55 years old receiving a single dose . on 7 january 2016 a trial involving multiple doses was started on six non placebo subjects . the first patient receiving the multiple doses was hospitalized at rennes university hospital on 10 january leading biotrial to suspend the study on 11 january . five patients were hospitalized with the first one receiving the multiple dose becoming brain dead . 11 12 13 references edit bial inovacao rdi ii european investment bank 7 april 2015 retrieved 19 january 2016 . eisai and bial announce partnership agreement for the european commercialisation of the novel once daily anti epileptic zebinix prnewswire february 19 retrieved 19 january 2016 fda approves aptiom to treat seizures in adults . us fda . 8 november 2013 . acetate as therapy in diabetic neuropathic pain clinical trials.gov u.s. national institutes of health july 17 2014 retrieved 19 january 2016 teresa nunes jos f. rocha manuel vaz da silva bruno igreja lyndon c. wright am lcar falc o luis almeida patricio soares da silva . safety tolerability and pharmacokinetics of etamicastat a novel dopamine hydroxylase inhibitor in a rising multiple dose study in young healthy subjects . drugs in r & d november 2010 volume 10 issue 4 pp 225 242 . doi 10.2165 11586310 000000000 00000 . retrieved 19 january 2016 igreja bruno ; pires nuno ; wright lyndon ; soares da silva patr cio bia 5 1058 is a new noncompetitive dopamine hydroxylase inhibitor journal of hypertension 30 e236 e23 august 2012 doi 10.1097 01 . hjh .0000420843.24708.5 e. retrieved 19 january 2016 jos francisco rocha luis almeida am lcar falc o et al. opicapone a short lived and very long acting novel catechol o methyltransferase inhibitor following multiple dose administration in healthy subjects . british journal of clinical pharmacology volume 76 issue 5 pages 763 775 november 2013 doi 10.1111 bcp .12081 retrieved 19 january 2016 helsinn group inks pact with bial for distribution licence of anamorelin in spain portugal angola & mozambique pharmabiz.com saffron media pvt. 9 september 2015 retrieved 19 january 2016 reuters editorial 15 january 2016 . brief bial says firmly committed to ensure wellbeing of test participants . reuters . reuters editorial 15 january 2016 . bial is maker of trial drug that hospitalised six volunteers french minister . reuters . lizzie dearden 15 january 2016 . france clinical trial prosecutors investigating accident as biotrial defends drug testing safety record . the independent . france clinical trial 90 given drug one man brain dead . bbc news . bbc news . bisserbe noemie . french drug trial for bial leaves one person brain dead four in hospital . the australian . external links edit bial retrieved from https en.wikipedia.org w index.php title bial & oldid 721557470 categories companies of portugalpharmaceutical companies of portugalportuguese brandscompanies established in 19241924 establishments in portugalhidden categories vague or ambiguous time from january 2016 navigation menu personal tools not logged intalkcontributionscreate accountlog in namespaces article talk variants views read edit view history more search navigation main pagecontentsfeatured contentcurrent eventsrandom articledonate to wikipediawikipedia store interaction helpabout wikipediacommunity portalrecent changescontact page tools what links hererelated changesupload filespecial pagespermanent linkpage informationwikidata itemcite this page print export create a bookdownload as pdfprintable version in other projects wikimedia commons languages deutschfran aisportugu s svenska edit links this page was last modified on 22 may 2016 at 17 15 . text is available under the creative commons attribution sharealike license ; 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