private company industry pharmaceutical founded 2000 headquarters new haven ct area served worldwide products broad spectrum antibiotics website www.rib x.com rib x pharmaceuticals founded in 2000 is an american privately held biopharmaceutical firm that focuses on the design and development of novel broad spectrum antibiotics for the treatment of antibiotic resistant infections in hospital and community settings . the company is located in new haven connecticut . 1 2 rib x seeks to exploit expertise in the structural biology particularly ribosomal structure and molecular modeling to design new antibiotics . with this technology they hope to design drug candidates with increased target affinity that overcome bacterial resistance broadened antibacterial spectrum and increased efficacy and safety . 2 contents 1 developmental candidates 1.1 pipeline in the clinical phase 1.2 rx 04 program 2 references 3 external links developmental candidates edit pipeline in the clinical phase edit rib x s pipeline includes the following compounds in the clinical phase delafloxacin a novel fluoroquinolone with activity against range of quinolone resistant gram positive and gram negative bacteria including mrsa currently in a phase 2b studys for hospital use . 2 delafloxacin was acquired from wakunaga pharmaceutical in 2006 . 3 radezolid a next generation oxazolidinone designed for broader spectrum enhanced potency and improved safety has completed two phase 2 studies . it has been shown to overcome linezolid resistance . 4 rx 04 program edit the company has several compounds in a pre clinical program designated rx 04 three new classes of compounds have been identified that target a novel site on the bacterial 50s ribosomal subunit . these compounds were designed using the rib x proprietary approach to rational drug design based on structural analysis of the bacterial ribosome . compounds have been identified with antibacterial activity against a number of the most difficult to treat clinically important multi drug resistant pathogens 5 including methicillin resistant staphylococcus aureus mrsa acinetobacter baumannii escherichia coli klebsiella pneumoniae and pseudomonas aeruginosa . 6 in mid 2011 sanofi entered into a global research collaboration and licensing option with rib x pharmaceuticals to develop and commercialize the novel classes of antibiotics resulting from rx 04 . 3 rib x also has three programs in the discovery phase designated rx 02 rx 05 and rx 06 . rx 06 is a program to develop anti fungals . 6 references edit rib x pharmaceuticals inc. bloomberg businessweek . accessed 14 oct 2011 . a b c related topics rib x pharmaceuticals . fierce biotech . accessed 14 oct 2011 . a b rib x pharmaceuticals signs global antibiotic research collaboration with sanofi . pharmadeals review vol 2011 issue 7 page 70 12 jul 2011 . accessed 14 oct 2011 . rib x pharmaceuticals presents data for radezolid demonstrating positive antibacterial activity and ability to overcome common bacterial resistance mechanism . drugs.com news clinical trials . 12 sep 2010 . accessed 14 oct 2011 . idsa hit list of dangerous microbes 2006 . a b rib x pharmaceuticals presents comprehensive overview of rx 04 program in 14 posters at icaac . drugs.com news clinical trials . 20 sep 2011 . accessed 14 oct 2011 . external links edit rib x pharmaceuticals homepage v t e pharmaceutical companies of the united states abbott laboratories acorda therapeutics actavis aderis pharmaceuticals adolor corporation alcon alexion pharmaceuticals alkermes allergan alza amgen amylin pharmaceuticals ariad pharmaceuticals aryx therapeutics avax technologies baxter international biocryst pharmaceuticals biogen biolex biovest biovista bradley pharmaceuticals bristol myers squibb cancervax century pharmaceuticals cephalon ceragenix pharmaceuticals combe incorporated cortex pharmaceuticals cotherix covance covidien cubist pharmaceuticals cutter laboratories cytosport cytrx danco laboratories dnaprint genomics epix pharmaceuticals eli lilly and company elorac endo pharmaceuticals ethicon endo surgery ethicon inc. forest laboratories galena biopharma genvec genentech genta gilead sciences hospira imclone systems institute for oneworld health intercept pharmaceuticals ista pharmaceuticals ivax corporation janssen biotech johnson & johnson kinetic concepts king pharmaceuticals kinray kv pharmaceutical leiner health products mallinckrodt martek biosciences corporation s. e. massengill company mckesson corporation mcneil laboratories melior discovery mentholatum merck & co. miles laboratories mylan myriad genetics naurex nereus pharmaceuticals northwest biotherapeutics norwich pharma services novabay pharmaceuticals nuvelo organon international ortho pharmaceutical ortho mcneil pharmaceutical osi pharmaceuticals ovation pharmaceuticals par pharmaceutical parke davis perrigo pfizer pharmaceutical product development prasco laboratories procter & gamble proteon therapeutics purdue pharma qualitest quark pharmaceuticals regeneron repros therapeutics rib x pharmaceuticals sarepta therapeutics savage laboratories schering plough g. d. searle & company sheffield pharmaceuticals smith kline & french spectrum pharmaceuticals sterling drug tanox tap pharmaceutical products tec laboratories teva pharmaceutical industries tiens biotech group titan pharmaceuticals trevena inc trubion upjohn upsher smith laboratories valeant pharmaceuticals ventria bioscience vertex pharmaceuticals verus pharmaceuticals vion pharmaceuticals inc. viropharma west pharmaceutical services wyeth zonite products corporation list of pharmaceutical companies retrieved from https en.wikipedia.org w index.php title rib x pharmaceuticals & oldid 653459261 categories companies based in connecticutpharmaceutical companies of the united stateshidden categories pages using infobox company with unsupported parameters navigation menu personal tools not logged intalkcontributionscreate 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