verification . please help improve this article by adding citations to reliable sources . unsourced material may be challenged and removed . august 2016 learn how and when to remove this template message toku e type private corporation industry manufacturing founded 1981 ; 35 years ago 1981 founder joseph ouyang headquarters bellingham wa usa key people q pan president products antibiotics antimicrobials life science and transfection number of employees 31 2016 website toku e.com toku e is a supplier of high purity antibiotics for biotechnology applications as selective antimicrobial reagents . 1 toku e s facilities include locations in the united states europe china and singapore . contents 1 history 2 products 3 resources 4 references 5 external links history edit toku e company was formed in 1981 in tokyo japan and employs engineers and specialists from all over the world in manufacturing facilities on almost every continent . throughout the 80s toku e concentrated on fermentation products . due to market demand the company diversified and began making instruments for animal health and needles used in electronic applications . in the 90s toku e expanded efforts into biotechnology and pharmaceutical research in comparative gene study and site specific mutations of antibiotics producing microorganisms through both private and public contract research and gradually became a reputable supplier of antibiotics for biopharmaceutical diagnostic and biotechnology research . in 2007 toku e had formed a grant making foundation in singapore toku e foundation to promote information sharing compound sharing and some technology sharing for antimicrobials . toku e foundation will provide funding to public research organizations for antibiotic resistant related studies . in 2015 toku e opened its european facility in zwijnaarde belgium to focus on research and development in separation chemistry . 2 products edit antimicrobials toku e specializes in manufacturing cell culture selection antibiotics and a wide variety of other antimicrobials for in vitro studies . antimicrobial structural categories include aminoglycosides azoles cephalosporins lipopeptides macrolides quinolones sulfamide penams peptides polyketides etc. evopure evopure is a product line developed by the toku e which employs proprietary chemical separation methods to produce highly purified single antibiotic fractions . many naturally occurring antibiotics are actually a mixture of related compounds with unknown biological activity . bacitracin for example is an antibiotic which consists of over ten known related fractions . these fractions are typically given a letter number impurity related compound or any combination to note a particular compound related to the parent . these names are typically established by the british pharmacopoeia chinese pharmacopoeia european pharmacopoeia japanese pharmacopoeia or united states pharmacopoeia . isolating these compounds have shown to be especially useful in gene selection applications where the goal is to inhibit growth of non transformed cells with antibiotics without harming selected cells . some examples of these compounds that contain these mixtures are as follows azithromycin bacitracin bleomycin clarithromycin cyclosporin enramycin erythromycin g418 gentamicin hygromycin kanamycin neomycin polymyxin roxithromycin tetracycline tylosin . resources edit antimicrobial index the toku e antimicrobial index allows users to cross reference literature based susceptibility data with hundreds of antibiotics thus allowing for more informed and efficient use of antimicrobials . currently the index contains both susceptibility and potency data for thousands of microorganisms and antimicrobial agents . the index contains over 69 300 microorganisms 7 850 unique strains and 4 100 antimicrobial agents . cell culture database the toku e cell culture database is a database designed to help scientists choose the most effective media and antibiotics for their cells . in addition the database suggests ideal concentrations and combinations of antibiotics for selection and transfection experiments . the easy to use database simply requires the user to enter the cell lines or plasmid vector and the search results produce an exhaustive list of several antibiotics and concentrations typically used for the specified cell line or plasmid . solubility data the toku e solubility data is a comprehensive list of solubility s of antimicrobial compounds in common solvents used in cell culture . references edit press release ultra pure antibiotics toku e . retrieved 2011 08 04 . http www.pishrotashkhis.com wp content uploads 2014 12 toku e company introduction1.pdf dead link external links edit toku e website retrieved from https en.wikipedia.org w index.php title toku e & oldid 735816966 categories research support companiescompanies established in 1981biotechnology companies of the united statespharmaceutical companies of the 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