primary sources . please improve this by adding secondary or tertiary sources . may 2009 learn how and when to remove this template message trubion type public company traded as nasdaq trbn industry biopharmaceutical fate acquired by emergent biosolutions 2010 founded 1999 headquarters seattle wa products protein based therapeutics website www.trubion.com trubion was a publicly held biopharmaceutical company that was focused on creating a pipeline of protein based therapeutic product candidates to treat autoimmune and inflammatory diseases and cancer . trubion was acquired by emergent biosolutions on october 28 2010 . 1 trubion was established in 1999 in the state of washington as an early stage development company and was later reincorporated in october 2002 in the state of delaware . in december 2005 trubion entered into a collaborative agreement with wyeth 2 for the development and worldwide commercialization of cd20 directed therapeutics . the agreement also included the development and worldwide commercialization of certain other product candidates directed to targets other than cd20 . the research portion of trubion s contract with wyeth extended through december 22 2009 . former product pipeline edit name platform indication status collaboration research tru 015 smip rheumatoid arthritis phase 2b wyeth phase 2b initiation 3 eular data 4 sbi 087 smip rheumatoid arthritis phase 1 wyeth recent data 5 sbi 087 smip systemic lupus erythematosus phase 1 wyeth tru 016 smip chronic lymphocytic leukemia phase 1 2 trubion proprietary technology asco 2008 poster presentation 6 tru 016 smip non hodgkin lymphoma pre clinical trubion proprietary technology tru 016 smip autoimmune disease and inflammation pre clinical trubion proprietary technology former technology edit trubion s product development efforts were focused on three technology pillars smip protein therapeutics scorpion protein therapeutics and tru adhance potency enhancing technology for immunopharmaceuticals . smip or small modular immunopharmaceutical therapeutics are single chain polypeptides comprising one binding domain one hinge domain and one effector domain designed in an effort to meet predetermined therapeutic specifications for specific diseases . smip therapeutics are mono specific they recognize and attach to single antigen targets and initiate biological activity . trubion worked on smip drug candidates that targeted validated antigens with the same specificity and predictable biological activity as mabs . scorpion protein therapeutics are also single chain polypeptides composed of functional domains from naturally occurring proteins . the difference between smip and scorpion technologies is that scorpion compounds are multi specific therapeutics that are capable of targeting two or more antigens simultaneously . tru adhance potency enhancing technology was designed to enhance the potency of existing therapies that work through fc directed or antibody directed cellular cytotoxicity or adcc . tru adhance technology could be applied late in development to established manufacturing lines and generate candidates with increased adcc and longer in vivo half lives . references edit http www.reuters.com article 2010 10 28 idus289053 28 oct 2010 bw20101028 http www.wyeth.com cbd history casestudies trubion http investors.trubion.com releasedetail.cfm releaseid 308846 http investors.trubion.com releasedetail.cfm releaseid 316893 http investors.trubion.com releasedetail.cfm releaseid 316893 http files.shareholder.com downloads trbn 284700491x0x200880 fa1aa005 f4db 4e6e bceb 1f230103998c trubion % 202008 % 20asco % 20poster.pdf v t e pharmaceutical companies of the united states abbott laboratories acorda therapeutics actavis aderis pharmaceuticals adolor corporation alcon alexion pharmaceuticals alkermes allergan alza amgen amylin pharmaceuticals ariad pharmaceuticals aryx therapeutics avax technologies baxter international biocryst pharmaceuticals biogen biolex biovest biovista bradley pharmaceuticals bristol myers squibb cancervax century pharmaceuticals cephalon ceragenix pharmaceuticals combe incorporated cortex pharmaceuticals cotherix covance covidien cubist pharmaceuticals cutter laboratories cytosport cytrx danco laboratories dnaprint genomics epix pharmaceuticals eli lilly and company elorac endo pharmaceuticals ethicon endo surgery ethicon inc. forest laboratories galena biopharma genvec genentech genta gilead sciences hospira imclone systems institute for oneworld health intercept pharmaceuticals ista pharmaceuticals ivax corporation janssen biotech johnson & johnson kinetic concepts king pharmaceuticals kinray kv pharmaceutical leiner health products mallinckrodt martek biosciences corporation s. e. massengill company mckesson corporation mcneil laboratories melior discovery mentholatum merck & co. miles laboratories mylan myriad genetics naurex nereus pharmaceuticals northwest biotherapeutics norwich pharma services novabay pharmaceuticals nuvelo organon international ortho pharmaceutical ortho mcneil pharmaceutical osi pharmaceuticals ovation pharmaceuticals par pharmaceutical parke davis perrigo pfizer pharmaceutical product development prasco laboratories procter & gamble proteon therapeutics purdue pharma qualitest quark pharmaceuticals regeneron repros therapeutics rib x pharmaceuticals sarepta therapeutics savage laboratories schering plough g. d. searle & company sheffield pharmaceuticals smith kline & french spectrum pharmaceuticals sterling drug tanox tap pharmaceutical products tec laboratories teva pharmaceutical industries tiens biotech group titan pharmaceuticals trevena inc trubion upjohn upsher smith laboratories valeant pharmaceuticals ventria bioscience vertex pharmaceuticals verus pharmaceuticals vion pharmaceuticals inc. viropharma west pharmaceutical services wyeth zonite products corporation list of pharmaceutical companies retrieved from https en.wikipedia.org w index.php title trubion & oldid 684934304 categories biotechnology companies of the united statespharmaceutical companies of the united statescompanies based in washington state companies formerly listed on nasdaqhidden categories articles lacking reliable references from may 2009all articles lacking reliable references navigation menu personal tools not logged intalkcontributionscreate accountlog in namespaces article talk variants views read edit view history more search navigation main pagecontentsfeatured contentcurrent eventsrandom articledonate to wikipediawikipedia store interaction helpabout wikipediacommunity portalrecent changescontact page tools what links hererelated changesupload filespecial pagespermanent linkpage informationwikidata itemcite this page print export create a bookdownload as pdfprintable version languages add links this page was last modified on 9 october 2015 at 18 18 . text is available under the creative commons attribution sharealike license ; 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