ltd. type private industry software life sciences healthcare founded 2000 headquarters bangalore karnataka india key people vijay chandru ceo ramesh hariharan cto kas subramanian cso products strandadvantage strand ngs heptox avadis website www.strandls.com strand life sciences is a privately held india based genomic profiling company that uses next generation sequencing ngs technology aimed at empowering cancer care . strand life sciences strandadvantage pan cancer panels provide medical oncologists a comprehensive understanding of genomic changes in solid tumors in days providing information that can be used by the physician in developing a targeted treatment plan . strand life sciences comprehensive knowledge base of genomic variants linked to fda approved targeted cancer therapies and drugs in open clinical trials provides clinically actionable treatment options enabling clinicians to develop a truly personalized treatment regimen for cancer patients . before its entry into the healthcare space strand focused on data mining predictive modeling computational chemistry software engineering bioinformatics and research biology to develop software and services for life sciences research . strand also offers custom solutions based on its intellectual property . contents 1 history 2 healthcare 2.1 strandadvantage 3 software 3.1 strand ngs formerly avadis ngs 3.2 genespring 3.3 avadis 3.4 sarchitect 3.5 arrayassist 4 accolades 5 references 6 external links history edit strand life sciences was founded in october 2000 by professors vijay chandru ramesh hariharan swami manohar and v. vinay . it was registered as strand genomics but was later renamed to strand life sciences as it dealt with various other aspects of life sciences . in august 2007 strand and agilent technologies inc. entered an agreement in which strand develops and supports agilent s genespring 1 software which agilent obtained through silicon genetics acquisition in august 2004 . 2 in october 2010 strand and agilent renewed the agreement 3 for strand to expand the scope of agilent s genespring across multiple life sciences disciplines . healthcare edit strandadvantage edit strandadvantage is a powerful new ngs based genomic profiling solution that helps physicians identify personalized treatment options for cancer patients . strand s pan cancer panel provides a complete view of the gene alterations that are driving cancer growth matched to relevant fda approved cancer therapies and clinical studies . delivering actionable results in just days strandadvantage enables more timely decisions about the most effective targeted therapies for patients . software edit strand ngs formerly avadis ngs edit strand ngs is a software platform for next generation sequencing data analysis . it can import raw read sequences from sequencing platforms like illumina ion torrent pacbio abi and 454 life sciences and supports fragment single end paired end mate paired directional single paired end library types . raw reads in formats fasta fastq sam bam unaligned bam bed counts data vcf val or eland formats can be imported into the tool . in addition perform split read alignment for detecting long indels and translocations . strand ngs also allows users to perform quality control on the imported data and filter reads before the main analysis is performed . version 2.6 of the tool supports six experiment types chip seq rna seq small rna methyl seq medip seq and dna seq. gene transcript snp homology gene ontology go and other annotations needed for analysis can be downloaded directly from within strand ngs website . the chip seq analysis workflow allows users to identify enriched regions using three different peak finding algorithms a simple sliding window based approach macs and pics . depending on the experiment design these regions could be transcription factor binding sites methylation sites etc. motifs present in the identified binding sites can be discovered using a parallel implementation of the gadem algorithm . entity lists containing the genes in the neighborhood of the binding regions can be created and used in downstream gene ontology gsea pathway analysis . the rna seq experiment workflow allows users to measure expression levels of known genes and transcripts . it also allows discovery of novel exons genes and splice junction . the genome browser in strand ngs enables users to validate the predictions by allowing viewing of the results in the context of annotations from multiple sources such as ncbi the ucsc genome browser and ensembl . statistical tests specifically designed to handling count based data can be used for differential gene expression and alternative splicing analysis . a special gene view visualization presents consolidated information about a gene and helps in the verifications of predictions . the dna seq experiment workflow has links for snp and structural variation detection algorithms . the snp prediction step finds homozygous and heterozygous snps and identifies overlaps with the provided dbsnp annotations . snps falling in genic regions are further analyzed and their effect on transcripts is described similar to the ensembl snp effect prediction web service . the structural variation analysis algorithms identify homozygous and heterozygous indels inversions and translocation events . in addition copy number variations can be detected using tumor normal pairs . visualization tools namely genome browser gene view and variant support view are a key aspect of the software . other visualizations available with tool are scatter plot mva plot profile plot histogram heat map box and whisker plot and venn diagram . aided with visualizations users a pictorial feel for statistical trends in the data . genome browser in strand ngs is an interface to visualize data results and annotations associated with the genome in one place . annotation data such as cytobands genes transcripts etc. as well as results from the analyses such as peak regions snps gene fusions etc. can be superimposed . users can drag and drop data into the browser and also perform search operations . to navigate in the genome browser users can scroll pan and zoom . users may also color filter and label data points of interest . gene view is used to visualize individual genes and their transcripts . users can see read coverage for known as well as novel exon partitions . strand ngs also provides access to organism specific interaction databases containing relations between proteins small molecules enzymes complexes biological processes molecular functions and gene families . the two million interactions present in these databases can also be augmented by importing pathways in gpml format wikipathways xml format biocyc biopax format from reactome cancer cell map etc. gene lists generated by analysis steps can be used as the starting point for many pathway analysis operations . genespring edit genespring gx version 9.0.0 onwards genespring workgroup version 7.0.0 onwards and mass profiler pro are developed by strand s r & d division in bangalore . avadis edit avadis is a comprehensive data mining and visualization platform . it combines the power of scalable algorithms and dynamic interactive visualization . the platform was customized for various scientific domains like gene expression next generation sequencing pre clinical research chemistry and healthcare . sarchitect edit sarchitect is a platform for modeling and predicting drug relevant properties of molecules in silico . arrayassist edit arrayassist was developed for stratagene inc. based on the avadis platform . the production was stopped after stratagene was acquired by agilent technologies inc. in 2007 . accolades edit strand is a red herring asia 100 private company for the years 2005 4 and 2010 . 5 deloitte fast 50 india and fast 500 asia in 2009 and 2010 . strand life sciences named as nasscom it innovator 2006 by nasscom . 6 it is one amongst seven indian companies to be recognized by nasscom as it innovators in 2007 . strand life sciences named as technology pioneer 2007 by the world economic forum . 7 strand has received the frost & sullivan excellence in technology award 2005 8 for its technology platform avadis . 2003 strand was nominated as a technology pioneer by the world economic forum for the year 2002 . genome technology magazine nominated strand as the top five most important companies in the category company of the year 2002 . references edit http www.agilent.com about newsroom presrel 2007 20aug ca07049.html http www.biodevicesbiz.com newsarticle.asp nid 84896 & cid 275 http www.agilent.com about newsroom presrel 2010 04oct ca10065.html http www.indecommglobal.com downloads rh sep 05 05.pdf http www.herring100.com rha2010 winners 2010winners.html http www.nasscom.in nasscom templates normalpage.aspx id 50719 http www.weforum.org en communities technology % 20pioneers selectedtechpioneers technologypioneers2007 index.htm http www.frost.com prod servlet press release.pag docid 44422323 external links edit strand life sciences retrieved from https en.wikipedia.org w index.php title strand life sciences & oldid 739653962 categories biotechnology companies of indiasoftware companies of indiacompanies established in 2000information technology companies of bangaloreprivately held companies of indiahidden categories use dmy dates from september 2016use indian english from september 2016all wikipedia articles written in indian englishpages using infobox company with unsupported parameters navigation menu personal tools not logged intalkcontributionscreate accountlog in namespaces article talk variants views read edit view history more search navigation main pagecontentsfeatured contentcurrent eventsrandom articledonate to wikipediawikipedia store interaction helpabout wikipediacommunity portalrecent changescontact page tools what links hererelated changesupload filespecial pagespermanent linkpage informationwikidata itemcite this page print export create a bookdownload as pdfprintable version languages add links this page was last modified on 16 september 2016 at 02 39 . text is available under the creative commons attribution sharealike license ; additional terms may apply . by using this site you agree to the terms of use and privacy policy . wikipedia is a registered trademark of the wikimedia foundation inc. a non profit organization . privacy policy about wikipedia disclaimers contact wikipedia developers cookie statement mobile view