group limited website http www.metascreen.org metascreen is an advanced non invasive metabolic screening test distributed by cordlife group limited cordlife . it can detect as many as 110 inborn errors of metabolism iems or metabolic disorders from a urine specimen . cordlife owns the brand name and trademark metascreen . contents 1 history 2 technology 3 use of urine as a diagnostic biofluid 4 products and services 5 controversies 6 references history edit metascreen as a newborn metabolic screening test was first launched by cordlife in india in october 2013 . 1 since april 2014 metascreen became available also in hong kong and the philippines through cordlife for parents looking for more comprehensive screening of metabolic disorders for their children . as a newborn suffering from certain metabolic disorder such as isovaleric acidemia may appear asymptomatic in the first few days or even weeks of life early detection and treatment is key in preventing irreversible lifelong complications such as physical disability or mental retardation . technology edit unlike the conventional dried blood spot test for newborn screening that involves a painful heel prick metascreen uses urine specimen collected without harm or discomfort to the newborn to detect as many as 110 metabolic disorders . the urine specimen is collected on a filter paper which is then air dried and sent to the laboratory for analysis using a gas chromatography mass spectrometry instrument gc ms . gc ms is a fda approved method for urinary analyte detection a gold standard for lipids drug metabolites and environmental analysis . 2 many of the iems that are classified as organic acidemia in which organic acids accumulate in the urine of newborns with these disorders 3 are easily and accurately picked up by gc ms. . the gc ms platform is recommended by the american college of medical genetics for the detection of organic and amino acidemias through the urine . 4 furthermore the platform has also been shown to be reliable in detecting other types of iems such as sugar metabolism disorders and fatty acid oxidation disorders . 3 5 indeed gc ms analysis is increasingly becoming a common way to diagnose iems for earlier intervention and treatment resulting in a better outcome and quality of life . use of urine as a diagnostic biofluid edit as a major organ for excretion the kidney removes waste materials and chemicals from the body 6 such as increased concentrations of intermediary metabolites of a particular pathway making urine the waste product from the kidney particularly useful for medical diagnostics . the key advantages of using urine as a biofluid are 1 its sterility ; 2 accessibility and non invasive method of collection ; and 3 it being largely free from interfering proteins or lipids . 7 although the human urine metabolome is a subset of the human serum metabolome more than 484 compounds identified in urine by bouatra et al. either experimentally or via literature review were not previously reported to be in blood . 7 the same group hypothesised that this is because the kidneys do an extraordinary job of removing and or concentrating certain metabolites from the blood hence compounds far below the limit of detection in blood using today s instrumentation are well above the detection limit in urine . 7 this difference combined with the ability of the kidneys to handle abnormally high or abnormally low concentrations of metabolites makes urine a particularly useful biofluid for medical diagnostics . 7 in fact urinary metabolites have been used to characterize nearly 220 diseases . 7 products and services edit at present metascreen is available only for newborns through cordlife clients selected clinics and hospitals . using gc ms instrumentation and proprietary planar bioinformatics where multiple analyte profiles are used to detect each metabolic disorder and benchmarked against international and local database of normal samples for the identification of an abnormal case metascreen can accurately and specifically identify the presence or absence of a metabolic disorder . up to 250 metabolites that are excreted in the urine are analysed using the gc ms for the detection of inborn errors of metabolism . the urine specimen of newborns should ideally be collected at 48 hours after birth or within the first 7 days of birth and after the newborn had at least a first feed to enable early detection and treatment of any identified metabolic disorder . most babies will test negative for metabolic disorders however if the newborn s test shows an abnormal result cordlife will immediately contact the attending physician for example the paediatrician who will then provide instructions on what to do next . controversies edit cordlife announced in october 2013 that cordlife india has introduced metascreen service through a strategic collaboration with navigene genetic science a genetic diagnostic and research company . 8 in 2014 navigene was embroiled in a controversy where its founders were accused of data and scientific research theft and fined for inr 3 million by the adjudicating authority of the department of information technology government of india . 9 10 navigene rejected all allegations 11 and has filed a writ petition no . wp 3291 2014 with the high court of mumbai to challenge and squash the order . references edit cordlife launches metascreen metabolic screening service . colin f. poole gas chromatography elsevier 2012 . a b kuhara 2001 . diagnosis of inborn errors of metabolism using filter paper urine urease treatment isotope dilution and gas chromatography mass spectrometry . j. chromatogr . b. 758 2001 3 25 . pdf . american college of medical geneticists standards and guidelines for clinical genetics laboratory . shoemaker j. d. 2010 . one step metabolomics carbohydrates organic and amino acids quantified in a single procedure j vis exp 40 . . wedmd information and resources your kidneys and how they work . a b c d e bouatra s aziat f mandal r guo ac wilson mr et al. 2013 the human urine metabolome . plos one 8 9 e73076 . . http cordlife.listedcompany.com newsroom 20131010 073220 p8a b592e3c2c146005048257bff0037d404.1.pdf https it.maharashtra.gov.in 1121 statement of cases id 3 http indianexpress.com article mumbai grammatical error nails copycat genetic research firm http www.dnaindia.com mumbai report firm slapped rs 30 lakh fine for data theft 1956820 retrieved from https en.wikipedia.org w index.php title metascreen & oldid 707188347 categories neonatologyinborn errors of metabolismepidemiologyrare diseases navigation menu personal tools not logged intalkcontributionscreate accountlog in namespaces article talk variants views read edit view history more search navigation main pagecontentsfeatured contentcurrent eventsrandom articledonate to wikipediawikipedia store interaction helpabout wikipediacommunity portalrecent changescontact page tools what links hererelated changesupload filespecial pagespermanent linkpage informationwikidata itemcite this page print export create a bookdownload as pdfprintable version languages add links this page was last modified on 27 february 2016 at 10 01 . text is available under the creative commons attribution sharealike license ; 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