of seattle type private industry biotechnology founded 2005 with 50 million capital raised to date from mpm capital ovp venture partners and arch founder william a. goddard iii david a. tirrell dee datta phd headquarters seattle washington usa slogan emerging technologies in protein therapeutics website http www.allozyne.com allozyne is a clinical stage clarification needed biotechnology company headquartered in seattle s biotech and high tech innovation corridor . where allozyne was founded in 2005 by california institute of technology researchers and was incubated clarification needed by accelerator corporation . 1 its lead product candidate az01 is a long acting interferon beta for the treatment of the relapsing remitting form of multiple sclerosis a chronic degenerative disease characterized by demyelination of nerve fibers leading to severe nerve damage and increasing disability . multiple sclerosis is estimated to affect 400 000 individuals in the us alone and 2.5 million worldwide . 2 az01 is currently undergoing phase i clinical trials in the us . preclinical data indicates that az01 has the potential to be dosed once monthly compared to the current standard of care dosed anywhere from once daily to once per week . 3 allozyne s technology also enables the development of next generation antibody drug conjugates adcs . this approach results in homogenous adc products that are stably conjugated . 4 in 2014 allozyne was acquired by medimmune based on its adc technology . financial terms of the transaction were not disclosed . 5 platform and therapeutic focus edit allozyne has a therapeutic focus on chronic central nervous system and autoimmune diseases such as multiple sclerosis and crohn s disease . their two platforms caesar and vigen re enable the creation of novel therapeutics that address unmet medical need associated with these diseases . the names of the two platforms were inspired by the two encryption techniques used prior to and during world war ii known as the caesar cipher and vigen re cipher . these platforms like historical ciphering technologies involve changes to the way messages are interpreted . these changes include modifications to the cellular machinery of both e. coli and mammalian cells so that the information encrypted in their dna can introduce a variety of protein building blocks beyond the 20 that are found in all proteins throughout nature . this process of biological encryption has come to be known as biociphering . additional available building blocks enable the creation more advanced protein therapeutics . the ability to customize the intrinsic properties and location of the 21st amino acid allows for a variety of bioconjugation chemistries to be directed to any specific location within the protein . these biociphering platforms have opened the door to new protein therapeutic configurations including antibody toxin antibody antibody long acting as well as others . application of these platforms to the development of protein based therapeutics enable therapeutics that address areas of unmet medical need . the first application of this technology was used to incorporate a variety of methionine analogs into human recombinant interferon beta . 6 one azide containing methionine analog was selected for its compatibility with a bioconjugation chemistry developed by nobel laureate k. barry sharpless of the scripps research institute known as click chemistry this chemistry enabled the engineering of a long acting form of human interferon beta by conjugation to a half life extending moiety known as polyethylene glycol peg . results were presented at the 2007 national acs meeting . 7 on july 15 2010 allozybe announced the signing of an exclusive license agreement with the scripps research institute for click chemistry . 8 references edit accelerator corporation launches allozyne lich rf buschbacher rm cox mj long wb winters kl becker dg 2004 . strategies to reduce hyperthermia in ambulatory multiple sclerosis patients . j long term eff med implants . 14 6 6 467 479 . pmid 15698375 . caon c din m ching w tselis a lisak r khan o may 2006 . clinical course after change of immunomodulating therapy in relapsing remitting multiple sclerosis . european journal of neurology . 13 5 5 471 474 . doi 10.1111 j. 1468 1331.2006.01273.x . pmid 16722971 . allozyne . adc review . retrieved 19 november 2015 . allozyne inc sold for scrap as medimmune snaps up rights . biospace.com . retrieved 19 november 2015 . wang a nairn nw johnson rs tirrell da grabstein k january 2008 . processing of n terminal unnatural amino acids in recombinant human interferon beta in escherichia coli . chembiochem . 9 2 324 330 . doi 10.1002 cbic .200700379 . pmid 18098265 . site specific pegylation of interferon beta by cu i catalyzed cycloaddition pdf . allozyne fortifies its proprietary position with a license for click chemistry a bioconjugation enabling cycloaddition technology from the scripps research institute press release . businesswire . 15 july 2010 . retrieved 21 july 2010 . external links edit official website coordinates 47 38 03 n 122 19 36 w 47.63415 n 122.326789 w 47.63415 ; 122.326789 retrieved from https en.wikipedia.org w index.php title allozyne & oldid 737200599 categories companies based in seattlepharmaceutical companies of the united stateshidden categories wikipedia articles needing clarification from november 2015vague or ambiguous geographic scope from november 2015coordinates not on wikidata navigation menu personal tools not logged intalkcontributionscreate accountlog in namespaces article talk variants views read edit view history more search navigation main pagecontentsfeatured contentcurrent eventsrandom articledonate to wikipediawikipedia store interaction helpabout wikipediacommunity portalrecent changescontact page tools what links hererelated changesupload filespecial pagespermanent linkpage informationwikidata itemcite this page print export create a 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