industry biotechnology founded 1998 founder david walt larry bock john stuelpnagel anthony czarnik mark chee headquarters san diego california u.s. key people francis desouza president & ceo revenue 2.2 billion 2015 website www.illumina.com illumina inc. is an american company incorporated in april 1998 that develops manufactures and markets integrated systems for the analysis of genetic variation and biological function . in 2014 illumina was named the world s smartest company by mit technology review . using its technologies the company provides a line of products and services that serve the sequencing genotyping and gene expression markets . this technology had purportedly by 2013 reduced the cost of sequencing a human genome to us 4 000 down from a price of us 1 million in 2007 . 1 customers include genomic research centers pharmaceutical companies academic institutions clinical research organizations and biotechnology companies . its tools provide researchers with the capability to perform genetic tests needed to extract medical information from advances in genomics and proteomics . its headquarters are located in san diego california . contents 1 history 2 products 2.1 dna methylation profiling 2.1.1 golden gate methylation 2.1.2 infinium methylation 2.1.3 dna sequencing 2.1.4 every genome 3 see also 4 references 5 external links history edit illumina was founded in april 1998 by david walt larry bock john stuelpnagel anthony czarnik and mark chee . while working with cw group a venture capital firm bock and stuelpnagel uncovered what would become illumina s beadarray technology at tufts university and negotiated an exclusive license to that technology . illumina completed its initial public offering in july 2000 . illumina began offering single nucleotide polymorphism snp genotyping services in 2001 and launched its first system the illumina beadlab in 2002 using goldengate genotyping technology . illumina currently offers microarray based products and services for an expanding range of genetic analysis sequencing including snp genotyping gene expression and protein analysis . illumina s technologies are used by a broad range of academic government pharmaceutical biotechnology and other leading institutions around the globe . on january 26 2007 the company completed the acquisition of hayward based solexa inc. solexa ltd based in cambridge uk was founded in june 1998 by shankar balasubramanian and david klenerman to develop and commercialize genome sequencing technology invented by the founders in the university of cambridge . solexa inc was formed 2005 when solexa ltd reversed into lynx therapeutics of hayward . technology uses also the dna colony sequencing technology invented in 1997 by pascal mayer and laurent farinelli 2 and which was acquired by solexa in 2004 from the company manteia predictive medicine . it is being used to perform a range of analyses including whole genome resequencing gene expression analysis and small ribonucleic acid rna analysis . in june 2009 illumina announced the launch of their own personal full genome sequencing service at a depth of 30x for 48 000 per genome 3 and a year later dropped the price to 19 500 . 4 this is still too expensive for true commercialization but the price will most likely decrease substantially over the next few years as they realize economies of scale and given the competition with other companies such as complete genomics and knome . 5 6 as of may 2011 update illumina reduced the price to 4 000 . 7 8 illumina acquired epicentre biotechnologies based in madison wisconsin on january 11 2011 . 9 on january 25 2012 hoffmann la roche made an unsolicited bid to buy illumina for 44.50 per share or about 5.7 billion . 10 11 roche tried other tactics including raising its offer to 51.00 for about 6.8 billion . 12 illumina rejected the offer 1 13 and roche abandoned the offer in april . 14 as of april 2013 update the company s chief executive officer was jay flatley . 1 in 2014 the company announced a multimillion dollar product hiseq x ten that it forecast would provide large scale whole genome sequencing for 1 000 genome . the company claimed that forty such machines would be able to sequence more genomes in one year than had been produced by all other sequencers to date . 15 in january 2014 illumina already held 70 percent of the market for genome sequencing machines . 16 illumina machines accounted for more than 90 percent of all dna data produced . 17 on july 5 2016 jay flatley assumed the role of executive chairman of the board of directors . francis desouza took on the role of president and chief executive officer and continues to serve on the illumina board of directors . 18 19 products edit dna methylation profiling edit golden gate methylation edit the goldengate methylation cancer panel allows the user to probe 1 505 cpg loci selected from 807 genes across a large sample size . the array based method allows 96 samples to be probed simultaneously on one array matrix . infinium methylation edit utilizing illumina s humanmethylation27 dna analysis beadchip and the infinium technology this method allows the user to map single methylation resolution for 27 578 cpg sites across over 14 000 genes . this chip has been replaced by the 450k methylation chip and later by the epic array covering about 850k sites . dna sequencing edit main articles illumina solexa sequencing and illumina dye sequencing illumina sells a number of very high throughput dna sequencing systems also known as dna sequencers based on technology developed by solexa . the technology features bridge amplification to generate clusters and reversible terminators for sequence determination . 20 21 the technology behind these sequencing systems involves ligation of fragmented dna to a chip followed by primer addition and sequential fluorescent dntp incorporation and detection . the current portfolio includes the following sequencers instrument versions output in single reads genome analyzer discontinued 300 million miniseq research use 25 million miseq family research use dx fda approved fgx forensic 1 25 million nextseq family nextseq 500 research use nextseq 550 with capabilities for selected arrays 130 400 million hiseq family hiseq 2500 3000 4000 x up to 2 3 billion depending on instrument every genome edit full genome sequencing service is sold solely through health care professionals not direct to consumer . see also edit list of companies of the united states i references edit a b c staff april 15 2013 . genomics . disruptors . forbes paper . p. 88 . kawashima eric h. ; laurent farinelli ; pascal mayer 2005 05 12 . patent method of nucleic acid amplification . retrieved 2012 12 22 inconsistent citations everygenome.com individual genome sequencing illumina inc. kerry dolan 2010 09 16 . illumina ceo on the lunch that launched him . forbes . daniel macarthur 2009 06 11 . illumina launches personal genome sequencing service for 48 000 . scienceblogs.com . archived from the original on june 16 2009 . kevin davies 2009 06 11 . illumina to offer 48 000 personal genome sequencing service . bio it world . illumina drops sequencing price to 4 000 utsandiego.com everygenome.com individual genome sequencing illumina inc. illumina . . investor relations news release . investor.illumina.com . 2011 01 11 . retrieved 2014 01 18 . roche roche offers to acquire all outstanding shares of illumina inc. to further strengthen its leading role in diagnostics five reasons illumina should fight roche s insulting low ball bid xconomy roche and illumina taking it personally . the economist 2012 04 18 . retrieved on 2013 09 05 . illumina board rejects roche s hostile tender roche decides not to extend its tender offer for illumina inc. young susan 2014 01 14 . illumina claims it s reached 1 000 genome milestone with new high throughput human genome sequencer mit technology review . technologyreview.com . retrieved 2014 01 18 . zimmerman eilene 18 february 2014 . 50 smartest companies illumina . mit technology review . massachusetts institute of technology . retrieved 25 august 2014 . regalado antonio . emtech illumina says 228 000 human genomes will be sequenced this year . mit technology review . massachusetts institute of technology . retrieved 26 september 2014 . jay flatley to assume role of executive chairman of the board of directors of illumina ; francis desouza appointed president and ceo press release . illumina . 7 march 2016 . self published source staff july 2016 . people . genetic engineering & biotechnology news paper . 36 13 . p. 37 . s balasubramanian rsc chem . commun . 47 26 7281 7286 2011 bentley david r. ; et al. 6 november 2008 . accurate whole human genome sequencing using reversible terminator chemistry . nature . 456 7218 53 59 . doi 10.1038 nature07517 . pmc 2581791 . pmid 18987734 . external links edit wikimedia commons has media related to illumina company . illumina s company website dnavision illumina official service provider . gene logic performs research based on illumina s golden gate assay illumina s personal full sequencing genome service national center for genome resources ncgr sequencing center an illumina certified service provider . genotypic technology genomics simplified an illumina certified service provider . v t e companies of the nasdaq 100 index 21st century fox activision blizzard adobe systems akamai technologies alexion pharmaceuticals alphabet amazon.com american airlines group amgen analog devices apple applied materials autodesk automatic data processing baidu bed bath & beyond biogen biomarin pharmaceutical broadcom limited ca technologies celgene cerner charter communications check point cisco systems citrix systems cognizant comcast costco csx ctrip.com international discovery communications dish network dollar tree ebay electronic arts endo international expedia express scripts facebook fastenal fiserv gilead sciences henry schein illumina incyte intel intuit intuitive surgical jd.com kraft heinz lam research liberty braves liberty global liberty interactive liberty media linear technology marriott international mattel maxim integrated products micron technology microsoft mondelez international monster beverage mylan netapp netflix norwegian cruise line holdings nvidia nxp semiconductors o reilly automotive paccar paychex paypal qualcomm regeneron ross stores sandisk sba communications seagate technology sirius xm holdings skyworks solutions starbucks stericycle symantec t mobile us tesla motors texas instruments the priceline group tractor supply company tripadvisor ulta salon cosmetics & fragrance verisk analytics vertex pharmaceuticals viacom vodafone walgreens boots alliance western digital whole foods market xilinx yahoo retrieved from https en.wikipedia.org w index.php title illumina company & oldid 743674788 categories companies in the nasdaq 100 indexcompanies listed on nasdaqcompanies in 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