type public traded as nyse wx industry biotech life sciences manufacturing founded san diego california united states 2001 headquarters usa area served worldwide products antibodies peptides custom antibody services custom peptide services custom protein services number of employees 200 2014 website www.abgent.com abgent is a global biotechnology company based in san diego california us with offices in maidenhead uk and suzhou china and distributors around the world . abgent develops antibodies and related agents to study proteins involved in cellular function and disease . abgent s antibodies target key areas of research including autophagy neuroscience cancer stem cells and more . abgent was acquired in 2011 by wuxi apptec nyse wx a global pharmaceutical biopharmaceutical and medical device outsourcing company with operations in china and the united states . 1 contents 1 peer review 2 core business 3 tools 3.1 sumoplot analysis program 3.2 autophagy receptor motif plotter 4 see also 5 references 6 external links peer review edit abgent was listed as a selected supplier in nature magazine 2 antibody technology drug discovery features and the scientist s cell signaling feature . more than 1 100 peer reviewed publications 3 in scientific journals have cited abgent antibody protein and peptide products and custom services . core business edit as one of the world s largest manufacturers of antibodies for biological research and drug discovery abgent develops produces and sells antibodies for use in academic biotechnological and pharmaceutical industries . core products are complemented by custom antibody services and custom protein services for drug discovery targets . tools edit sumoplot analysis program edit sumoplot is a tool used to predict sumoylation sites an important post translational modification of proteins . sumo modified proteins contain the tetrapeptide motif b k x d e where b is a hydrophobic residue k is the lysine conjugated to sumo x is any amino acid aa d or e is an acidic residue . substrate specificity appears to be derived directly from ubc9 and the respective substrate motif . sumoplot predicts the probability for the sumo consensus sequence sumo cs to be engaged in sumo attachment . the sumoplot score system is based on two criteria 1 direct amino acid match to the sumo cs observed and shown to bind ubc9 and 2 substitution of the consensus amino acid residues with amino acid residues exhibiting similar hydrophobicity . sumoplot has been used in the past to predict ubc9 dependent sites . 4 5 6 7 8 9 10 11 12 autophagy receptor motif plotter edit the autophagy pathway is mediated by selective receptors . they recognize and sort diverse cargo substrates e.g. proteins organelles pathogens for delivery to the autophagic machinery . known autophagy receptors are characterized by short linear sequence motifs autophagy receptor motifs or arms responsible for the interaction with the atg8 lc3 family . many arm containing proteins arm cps are also involved in autophagosome formation and maturation and a few of them in regulating signaling pathways . autophagy receptor motif plotter assists in the identification of novel arm cps . users input a given an amino acid sequence into the web enabled tool and the program identifies internal sequences matching a pattern within the 3 classes of the extended arm motif x6 w f yxxx x2 . the program then computes and lists the top four scores for each motif class w f y . the full sequence of the arm cp is displayed where arms are colored by their score and ranked score values are presented in tabular form . 13 14 15 see also edit antibodies autophagy database neurodegenerative disorders stem cell marker sumo protein references edit wuxi pharmatech acquires abgent a leading producer of biological research reagents . oct 14 2011 . technology feature table of suppliers . 2004 nature 428 6979 p232 hirewire abgent publication search results gramatikoff k. et al. in frontiers of biotechnology and pharmaceuticals science press usa inc 2004 ; 4 181 210 vyacheslav yurchenko zhu xue and moshe j. sadofsky . sumo modification of human xrcc4 regulates its localization and function in dna double strand break repair mol . cell . biol . mar 2006 ; 26 1786 1794 meiluen yang chia tse hsu chun yuan ting leroy f. liu and jaulang hwang . assembly of a polymeric chain of sumo1 on human topoisomerase i in vitro j. biol . chem . mar 2006 ; 281 8264 8274 yutaka morita chie kanei ishii teruaki nomura and shunsuke ishii . traf7 sequesters c myb to the cytoplasm by stimulating its sumoylation . mol . biol . cell nov 2005 ; 16 5433 5444 zhongshu tang oussama el far heinrich betz and astrid scheschonka . pias1 interaction and sumoylation of metabotropic glutamate receptor 8 . j. biol . chem . nov 2005 ; 280 38153 38159 brigit e. riley huda y. zoghbi and harry t. orr . sumoylation of the polyglutamine repeat protein ataxin 1 is dependent on a functional nuclear localization signal . j. biol . chem . jun 2005 ; 280 21942 21948 timothy a. hinsley pamela cunliffe hannah j. tipney andrew brass and may tassabehji . comparison of tfii i gene family members deleted in williams beuren syndrome . protein sci . oct 2004 ; 13 2588 2599 frederik van dyck els l. d. delvaux wim j. m. van de ven and marcela v. chavez . repression of the transactivating capacity of the oncoprotein plag1 by sumoylation . j. biol . chem . aug 2004 ; 279 36121 36131 . tianwei li evgenij evdokimov rong fong shen chien chung chao ephrem tekle tao wang earl r. stadtman david c. h. yang and p. boon chock . sumoylation of heterogeneous nuclear ribonucleoproteins zinc finger proteins and nuclear pore complex proteins a proteomic analysis . pnas jun 2004 ; 101 8551 8556 noda et al 2010 febs letters 584 1379 85 pmid 20083108 birgisdottir et al 2013 j cell sci 126 3237 47 pmid 23908376 rogov et al 2014 molecular cell 53 167 78 pmid 24462201 external links edit abgent official website this article incorporates public domain material from the ncbi document science primer . retrieved from https en.wikipedia.org w index.php title abgent & oldid 743674345 categories biotechnology companies of the united statescompanies based in san diegohidden categories wikipedia articles incorporating text from the united states national library of medicine navigation menu personal tools not logged intalkcontributionscreate accountlog in namespaces article talk variants views read edit view history more search navigation main pagecontentsfeatured contentcurrent eventsrandom articledonate to wikipediawikipedia store interaction helpabout wikipediacommunity portalrecent changescontact page tools what links hererelated changesupload filespecial pagespermanent linkpage informationwikidata itemcite this page print export create a bookdownload as pdfprintable version languages add links this page was last modified on 10 october 2016 at 17 32 . text is available under the creative commons attribution sharealike license ; 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