company that has developed and commercialized a dna sequencing platform for human genome sequencing and analysis . this solution combines the company s proprietary human genome sequencing technology with its informatics and data management software to provide finished variant reports and assemblies at complete genomics own commercial genome center in mountain view california . in march 2013 complete genomics was acquired by bgi shenzhen the world s largest genomics services company . bgi is a 4 000 person company headquartered in shenzhen guangdong china that provides comprehensive sequencing and bioinformatics services for commercial science medical agricultural and environmental applications . 1 contents 1 history 2 technology platform 3 references 4 external links history edit complete genomics was founded in march 2006 by clifford reid radoje rade drmanac and john curson . clifford reid was the chairman president and chief executive officer of complete genomics . in february 2009 complete genomics announced that it had sequenced its first human genome and submitted the resulting variant data to the national center for biotechnology information database . then in november 2009 complete genomics published sequence data for three human genomes in the journal science . 2 by the end of 2009 complete genomics had sequenced 50 human genomes . to date the company has sequenced more than 20 000 genomes . the resulting data has supported research in diverse areas such as screening of embryos 3 detection of genetic relationships 4 5 neurology 6 aging 7 a novel mendelian disease with neuromuscular and cardiac involvement 8 eating disorders 9 prader willi syndrome and autism 10 ophthalmology 11 and oncology . 12 13 14 15 16 in 2014 a collaboration among radboud university the netherlands maastricht university medical centre the netherlands central south university china and complete genomics identified major causes of intellectual disability using whole genome sequencing . 17 technology platform edit complete genomics proprietary human genome sequencing technology is optimized for the exclusive study of human dna providing assembled sequences and variation files . the technology relies on dna nanoball sequencing . it is designed to use lower volumes and concentrations of reagents than existing systems . additionally complete genomics proprietary instrumentation allows for greater numbers of base reads per image . 2 references edit specter michael 6 january 2014 the gene factory the new yorker retrieved 28 october 2014 a b drmanac r ; sparks a. b. ; callow m. j. ; halpern a. l. ; burns n. l. ; kermani b. g. ; carnevali p. ; nazarenko i. ; nilsen g. b. ; yeung g. ; dahl f. ; fernandez a. ; staker b. ; pant k. p. ; baccash j. ; borcherding a. p. ; brownley a. ; cedeno r. ; chen l. ; chernikoff d. ; cheung a. ; chirita r. ; curson b. ; ebert j. c. ; hacker c. r. ; hartlage r. ; hauser b. ; huang s. ; jiang y. ; et al. november 2009 . human genome sequencing using unchained base reads on self assembling dna nanoarrays . science . 327 5961 78 81 . bibcode 2010sci ... 327 ... 78d . doi 10.1126 science .1181498 . pmid 19892942 . winard r ; et al. 2014 . in vitro screening of embryos by whole genome sequencing now in the future or never . hum reprod . 29 4 842 851 . doi 10.1093 humrep deu005 . li h ; et al. 2014 . relationship estimation from whole genome sequence data . plos genet . 10 1 e1004144 . doi 10.1371 journal.pgen .1004144 . su s y ; et al. 2012 . detection of identity by descent using next generation whole genome sequencing data . hbmc bioinformatics . 13 121 . doi 10.1186 1471 2105 13 121 . bundo m 2014 . increased l1 retrotransposition in the neuronal genome in schizophrenia . neuron . 81 2 306 313 . doi 10.1016 j.neuron .2013.10.053 . pmid 24389010 . kai y ; et al. 2013 . aging as accelerated accumulation of somatic variants whole genome sequencing of centenarian and middle aged monozygotic twin pairs . twin research and human genetics . 16 6 1026 1032 . wang k ; et al. 2013 . whole genome dna rna sequencing identifies truncating mutations in rbck1 in a novel mendelian disease with neuromuscular and cardiac involvement . genome medicine . 5 7 67 . doi 10.1186 gm471 . pmid 23889995 . cui h ; et al. 2013 . eating disorder predisposition is associated with esrra and hdac4 mutations . j clin invest . 123 11 4706 4713 . doi 10.1172 jci71400 . schaaf cp ; et al. 2013 . truncating mutations of magel2 cause prader willi phenotypes and autism . nature genetics . 45 1405 1408 . doi 10.1038 ng .2776 . nishiguchi km ; et al. 2012 . genes associated with retinitis pigmentosa and allied diseases are frequently mutated in the general population . plos one . 7 7 e41902 . bibcode 2012ploso ... 741902n . doi 10.1371 journal.pone .0041902 . ma y ; et al. 2012 . developmental timing of mutations revealed by whole genome sequencing of twins with acute lymphoblastic leukemia . proc natl acad sci usa . 110 18 7429 7433 . bibcode 2013pnas . .110.7429 m. doi 10.1073 pnas .1221099110 . kiel mj ; et al. 2012 . whole genome sequencing identifies recurrent somatic notch2 mutations in splenic marginal zone lymphoma . the journal of experimental medicine . 209 9 1553 1565 . doi 10.1084 jem .20120910 . molenaar jj ; et al. 2012 . sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes . nature . 483 589 593 . bibcode 2012natur .483 . .589 m. doi 10.1038 nature10910 . turajlic s ; et al. 2011 . whole genome sequencing of matched primary and metastatic acral melanomas . genome res . 22 196 207 . doi 10.1101 gr .125591.111 . yokoyama s ; et al. 2011 . ga novel recurrent mutation in mitf predisposes to familial and sporadic melanoma . nature . 480 99 103 . bibcode 2011natur .480 ... 99y . doi 10.1038 nature10630 . gilissen c ; et al. 2014 . genome sequencing identifies major causes of severe intellectual disability . nature . 511 7509 344 347 . bibcode 2014natur .511 . .344 g. doi 10.1038 nature13394 . pmid 24896178 . external links edit official website retrieved from https en.wikipedia.org w index.php title complete genomics & oldid 717678511 categories biotechnology companiescompanies established in 2006genomics companiescompanies based in mountain view californiatechnology companies based in the san francisco bay area navigation menu personal tools not logged intalkcontributionscreate accountlog in namespaces article talk variants views read edit view history more search navigation main pagecontentsfeatured contentcurrent eventsrandom articledonate to wikipediawikipedia store interaction helpabout wikipediacommunity portalrecent changescontact page tools what links hererelated changesupload filespecial pagespermanent linkpage informationwikidata itemcite this page print export create a bookdownload as pdfprintable version languages simple english edit links this page was last modified on 29 april 2016 at 02 57 . text is available under the creative commons attribution sharealike license ; 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