trials network type non profit organization industry hiv vaccine research headquarters seattle washington key people lawrence corey lead pi website http www.hvtn.org the hiv vaccine trials network hvtn is a non profit organization which connects physicians and scientists with activists and community educators for the purpose of conducting clinical trials seeking a safe and effective hiv vaccine . collaboratively research professionals and laypeople review potential vaccines for safety immune response and efficacy . the hvtn is the only hiv vaccine research network sponsored nationwide by the american government . citation needed it also manages the only large scale hiv vaccine research trial network in africa . citation needed the hvtn collaborates with the division of acquired immunodeficiency syndrome daids . funding comes from the national institute of allergy and infectious diseases and national institutes of health 1 which oversee daids . hvtn is headquartered at the fred hutchinson cancer research center in seattle . 2 the vaccines being tested come from various producers both commercial and non profit . 3 the hvtn is a network for testing vaccines and while its members may also work in vaccine development for other entities the mission of the hvtn does not include vaccine design . contents 1 community involvement 2 african hiv vaccine research trials 3 step study 4 current projects 4.1 hvtn 505 5 see also 6 references 7 external links community involvement edit typically researchers conduct clinical research on human subjects by asking volunteers to give informed consent to participate in an experiment by taking drugs that have not always been proven safe or effective in humans though their safety has been tested usually in animals prior to any human trials . at the hvtn many current vaccine studies are using products with a safety record that has been established in previous human trials . the nuremberg code the declaration of helsinki and the belmont report are legal documents written in layman s terms which local governments use to model their laws for establishing rules for conducting clinical trials and all contemporary clinical trials of international worth follow all the rules set by these precedents . however hiv vaccine research requires more than just these protections and because of this from the inception of their research the hvtn has instituted a community advisory board cab system in addition to the usual controls . the cab is similar to an institutional review board irb in that the researchers facilitate the granting of public data to both entities but the difference is that the irb consists of a professional ethics committee and the cab consists of any community member who wants to supervise the safety ethics efficacy or any other aspect of the research . 4 the researchers of the hvtn deemed the creation of the cab necessary for hiv vaccine research when it has not been necessary for other clinical research because the hiv epidemic is especially urgent new research techniques are available now that did not exist before recent major advances in genetic engineering the public is generally overly willing to volunteer to receive experimental vaccines for this cause and yet the educational infrastructure already in place to disseminate information about the inherent risk in participating in vaccine research is lacking in society . 5 for too many reasons there is no precedent for research of this sort on this scale 6 and without integrating educational programs about this research into existing community institutions the hvtn simply could not educate people to the required level to make such a fast moving expensive inherently non commercial research project possible . african hiv vaccine research trials edit in 2003 the hvtn partnered with harvard university in establishing a small scale vaccine trials unit in botswana . 7 a major reason for this project was gathering data about the prevalence of hiv in africa and assessing the feasibility of getting grassroots support for vaccine trials in non american culture . in 2007 hvtn started the first large scale hiv vaccine trials in africa with financial assistance from the sa aids vaccine initiative . these studies will last until 2011 and include up to 3000 participants . 8 9 one of those trials begun in 2007 the phambili trial 10 was halted in 2007 due to its similarity to the ineffective vaccine used in the american step study . 11 step study edit main article step study step was the name for a double blind randomized controlled trial managed by the hvtn . it was thoroughly reviewed when a greater number of participants in the experimental group contracted hiv than the participants in the control group . the vaccine contained no hiv and no one could have contracted hiv from the vaccine but there was intense discussion as to whether the vaccine could have increased anyone s risk of contracting hiv . because the study was stopped early it probably will never be possible to determine why more participants in the experimental group contracted hiv but various theories have been proposed . citation needed current projects edit hvtn 505 edit main article hvtn 505 on october 1 2009 the hvtn began a new clinical trial called hvtn 505 . 12 hvtn 505 is a project to examine whether a particular dna prime boost vaccine regimen will reduce viral load in individuals who later become infected with hiv . the experimental vaccine used in this study was developed by the vaccine research center at the national institutes of health nih . study organizers do not expect that this vaccine will prevent hiv infection and thus this vaccine is not planned for licensing but it is expected to cause a response that will help researchers decide how to direct future vaccine trials . 13 see also edit world aids vaccine day julie mcelrath references edit about the hvtn . hvtn website . retrieved 2008 10 29 . fred hutchinson cancer research center named as core operations center for worldwide hiv vaccine trials network . fhcrc press release . 2000 05 25 . retrieved 2008 10 29 . dead link current vaccine trials . hvtn website . retrieved 2008 10 29 . community advisory board cab . hvtn website . retrieved 2008 10 29 . building a vaccine legacy on trust . fhcrc center news . 2005 02 03 . retrieved 2008 10 29 . joining a community advisory board . the body . 2003 12 20 . retrieved 2008 10 29 . harvard aids institute helps launch hiv vaccine trial in botswana . harvard public health now . 2003 08 08 . africa s first large scale hiv vaccine study launches . medical news today . 2007 02 09 . retrieved 2007 03 08 . volunteers join hiv vaccine trial . iol . retrieved 2007 03 08 . africa s first large scale hiv vaccine study launches . medical news today . 2007 02 09 . retrieved 2008 10 29 . status of niaid adenovirus based vaccine studies . niaid . archived from the original on 2008 10 01 . retrieved 2008 10 29 . matthew s. bajko 2009 10 01 . new trial of hiv vaccine in gay men begins . bay area reporter . the hvtn 505 study its role in helping fight aids pdf press release . hvtn.org . 2009 10 01 . retrieved 2009 11 21 . external links edit hiv vaccine trials network hope takes action fred hutchinson cancer research center division of acquired immunodeficiency syndrome nih v t e fred hutchinson cancer research center key people william b. hutchinson m.d. fred hutchinson lawrence corey president linda b. buck leland h. hartwell e. donnall thomas mark roth organizations on campus hiv vaccine trials network sage bionetworks office of hiv aids network coordination v t e hiv aids topics hiv aids hiv hiv structure and genome subtypes cdc classification disease progression rates hiv aids diagnosis management pathophysiology prevention research vaccination prep who disease staging system for hiv infection and disease children teens adults countries by aids prevalence rate conditions signs and symptoms aids defining clinical condition diffuse infiltrative lymphocytosis syndrome lipodystrophy nephropathy neurocognitive disorders pruritus superinfection tuberculosis co infection hiv drug resistance database innate resistance to hiv history history epidemiology timeline aids museum social aids orphan catholic church and hiv aids circumcision and hiv criminal transmission discrimination against people economic impact hiv affected community hiv aids denialism safe sex sex education list of hiv positive people people with aids self empowerment movement culture international aids conference international aids society joint united nations programme on hiv aids unaids president s emergency plan for aids relief pepfar treatment action campaign world aids day media portrayal of hiv aids misconceptions about hiv aids discredited hiv aids origins theories aids pandemic by region country africa angola benin botswana democratic republic of the congo egypt ethiopia ghana guinea c te d ivoire ivory coast kenya lesotho madagascar malawi mali mozambique namibia niger nigeria rwanda senegal swaziland tanzania south africa uganda zambia zimbabwe north america canada united states new york city latin america bolivia brazil colombia el salvador guatemala guyana honduras mexico nicaragua peru asia bangladesh bhutan myanmar burma cambodia china prc yunnan east timor india indonesia iraq japan jordan laos nepal pakistan philippines thailand taiwan roc united arab emirates vietnam caribbean haiti jamaica dominican republic europe united kingdom russia ukraine oceania australia new zealand papua new guinea list of countries by hiv aids adult prevalence rate list of hiv aids cases and deaths registered by region v t e artificial induction of immunity immunization vaccines vaccination infection inoculation j07 development adjuvants list of vaccine ingredients mathematical modelling timeline trials classes conjugate vaccine dna vaccination inactivated vaccine live vector vaccine attenuated vaccine heterologous vaccine subunit component peptide virus like particle toxoid administration global gavi alliance policy schedule vaccine injury usa acip vaccine court vaccines for children program vaers vsd vaccines bacterial anthrax brucellosis cholera diphtheria hib leptospirosis lyme disease meningococcus menzb nmvac4 a c y w 135 pertussis plague pneumococcal pcv ppsv q fever tetanus tuberculosis bcg typhoid ty21a vicps typhus combination dtwp dtap viral adenovirus flu h1n1 pandemrix laiv hantavirus hepatitis a hepatitis b hepatitis e hpv cervarix gardasil japanese encephalitis measles mumps mumpsvax polio sabin salk rabies rotavirus rubella smallpox dryvax tick borne encephalitis varicella zoster chicken pox shingles live yellow fever combination mmr mmrv research chikungunya cytomegalovirus dengue ebola epstein barr virus hepatitis c hiv protozoan research malaria trypanosomiasis helminthiasis research hookworm schistosomiasis other cancer vaccines alvac cea hepatitis b hpv cervarix gardasil nicvax ta cd ta nic controversy general mmr ncvia pox party thiomersal andrew wakefield cedillo v. secretary of health and human services alternative vaccination schedule see also epidemiology eradication of infectious diseases list of vaccine topics who em withdrawn from market clinical trials phase iii never to phase iii retrieved from https en.wikipedia.org w index.php title hiv vaccine trials network & oldid 738547250 categories hiv aids in the united stateshiv aids in south africahiv vaccine researchhiv aids organizationsvaccination related organizationsresearch institutes in seattlehidden categories all articles with dead external linksarticles with dead external links from september 2016all articles with unsourced statementsarticles with unsourced statements from december 2010articles with unsourced statements from june 2011 navigation menu personal tools not logged intalkcontributionscreate accountlog in namespaces article talk variants views read edit view history 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