tsi type private industry biotechnology headquarters cambridge ma website 1 thrombolytic science international tsi is a private biopharmaceutical company beginning phase i clinical trials of ts01 a new generation therapy to treat acute strokes and heart attacks . 1 tissue plasminogen activator tpa has remained the only clot dissolving thrombolytic drug available for clinical use in patients with ischemic stroke since its approval in 1996 . 2 only about 5 % of stroke patients are treated with tpa because of its short treatment time window suboptimal efficacy and risk of intra cranial hemorrhage . 3 ts01 is a clot dissolving treatment consisting of a mutated form of the first generation thrombolytic pro urokinase pro uk preceded by a bolus of plasma complement 1 esterase inhibitor c1 inhibitor . 4 ts01 targets only the occlusive bad clots that lead to stroke a fact which the company expects will significantly reduce the risk of bleeding . like its parent molecule pro uk ts01 is also expected to show a longer treatment time window than tpa . these attributes will allow many more patients to be treated with this potentially life saving treatment . 5 peer reviewed articles edit liu jn ; jx jiu ; b liu ; z sun ; p zhang ; v gurewich march 2002 . a prourokinase mutant which induces highly effective clot lysis without interfering with hemostasis . circulation research . 90 757 763 . doi 10.1161 01 . res .0000014825.71092 . bd . references edit hay timothy . 12 january 2012 . with 7.5 m tsi aims to succeed where bat spit snake venom failed . dow jones venturewire . haas michael j. . 22 march 2012 . monkeys bridge the stroke gap . scibx . rhodes jennifer . 6 february 2012 . specifying stroke . biocentury . haas michael j. . 22 march 2012 . monkeys bridge the stroke gap . scibx . rhodes jennifer . 6 february 2012 . specifying stroke . biocentury . external links edit tsi website retrieved from https en.wikipedia.org w index.php title thrombolytic science international & oldid 647147248 categories biotechnology companies of the united statesprivately held companies based in massachusettscompanies based in cambridge massachusetts navigation menu personal tools not logged intalkcontributionscreate accountlog in namespaces article talk variants views read edit view history more search navigation main pagecontentsfeatured contentcurrent eventsrandom articledonate to wikipediawikipedia store interaction helpabout wikipediacommunity portalrecent changescontact page tools what links hererelated changesupload filespecial pagespermanent linkpage informationwikidata itemcite this page print export create a bookdownload as pdfprintable version languages add links this page was last modified on 14 february 2015 at 20 27 . text is available under the creative commons attribution sharealike license ; additional terms may apply . by using this site you agree to the terms of use and privacy policy . wikipedia is a registered trademark of the wikimedia foundation inc. a non profit organization . privacy policy about wikipedia disclaimers contact wikipedia developers cookie statement mobile view