articles link to it . please introduce links to this page from related articles ; try the find link tool for suggestions . february 2009 trophogen inc. type private industry biotechnology founded 2001 headquarters rockville maryland 39 05 48 n and 77 07 47 w key people bruce weintraub coo & cso mariusz szkudlinski vp research and development number of employees 7 2013 website http www.trophogen.com trophogen inc. is a biotechnology company based in rockville maryland . company was founded in 2001 with series a funding from toucan capital 1 2 focusing on the development of human and bovine high affinity glycoprotein hormone and related growth factor superagonist analogs 3 for human infertility and animal superovulation as well as targeted therapy and imaging of thyroid ovarian breast prostate and testicular cancers . 4 contents 1 technology 2 lead product candidates 3 references 4 external links technology edit the key to trophogen s long acting superagonist proprietary patented technology is to carefully engineer new analogs to increase their affinity to the receptor . this is achieved by substituting crucial amino acids in the receptor binding domain increasing affinity up to 100 fold . the addition of neoglycosylation sites extends the half life of those analogs without extensions or subunit linkers improving treatment convenience by reducing the number of injections . trophogen s technology represents the first successful design of super active analogs of glycoprotein hormones that shows major increases in bioactivity and far exceeds results shown for other protein ligands 5 lead product candidates edit recombinant long acting high potency human fsh superagonist analog for infertility and elective egg banking . recombinant long acting high potency human tsh superagonist analog for imaging and treatment of thyroid cancer . recombinant long acting high potency bovine fsh superagonist analog for superovulation and embryo transfer in beef and dairy cows . recombinant long acting high potency equine cg superagonist analog for superovulation and embryo transfer in pigs . recombinant long acting high potency human vegf superagonist for imaging and therapy of thyroid and multiple other cancers . recombinant long acting high potency human lh superagonist for infertility therapy . recombinant long acting high potency bovine lh superagonist analog for maintenance of pregnancy in beef and dairy cows . recombinant long acting high potency vegf superagonist for imaging and therapy of thyroid and other cancers in dogs and other animals . references edit breaking with academia a tough choice for scientists . the daily record march 2002 local biotech pulls nih license away from giant pharma . washington business journal march 2002 effects of recombinant human thyroid stimulating hormone superagonists on thyroidal uptake of 18f fluorodeoxyglucose and radioiodide . thyroid . 2011 jul ; 21 7 783 92 . doi 10.1089 thy .2010.0394 . epub 2011 may 13 adventure with ventures . the scientist february 2006 trophogen wants to score 10m development deals . washington business journal march 2007 . external links edit official website retrieved from https en.wikipedia.org w index.php title trophogen & oldid 574495346 categories companies based in rockville marylandbiotechnology companies of the united stateshidden categories orphaned articles from february 2009all orphaned articles navigation menu personal tools not logged intalkcontributionscreate accountlog in namespaces article talk variants views read edit view history more search navigation main pagecontentsfeatured contentcurrent eventsrandom articledonate to wikipediawikipedia store interaction helpabout wikipediacommunity portalrecent changescontact page tools what links hererelated changesupload filespecial pagespermanent linkpage informationwikidata itemcite this page print export create a bookdownload as pdfprintable version languages add links this page was last modified on 25 september 2013 at 18 30 . text is available under the creative commons attribution sharealike license ; additional terms may apply . by using this site you agree to the terms of use and privacy policy . wikipedia is a registered trademark of the wikimedia foundation inc. a non profit organization . privacy policy about wikipedia disclaimers contact wikipedia developers cookie statement mobile view