written like an advertisement . please help improve it by removing promotional content and inappropriate external links and by adding encyclopedic content written from a neutral point of view . september 2012 learn how and when to remove this template message simulations plus inc. type public traded as nasdaq slp industry software founded 1996 in lancaster california founder walter woltosz headquarters lancaster california usa products software gastroplus admet predictor medchem studio dddplus medchem designer membraneplus number of employees 60 website www.simulations plus.com simulations plus inc. develops absorption distribution metabolism excretion and toxicity admet modeling and simulation software for the pharmaceutical and biotechnology industrial chemicals cosmetics food ingredients and herbicide industries . in september 2014 the company acquired cognigen corporation a leading provider of clinical trial data analysis and consulting services . contents 1 software programs 1.1 notes 2 references 3 external links software programs edit the company has produced specific proprietary software products such as gastroplus a physiologically based simulation tool that predicts the absorption pharmacokinetics pharmacodynamics and drug drug interactions for drugs administered through intravenous oral ocular or pulmonary routes . the modeling theory and approach has been discussed in several peer reviewed publications . 1 2 3 4 5 6 7 admet predictor a modeling program that enables pharmaceutical researchers to estimate admet properties from chemical structure . the performance of the models have been assessed in several peer reviewed articles . 8 9 10 admet modeler a module of admet predictortm that allows scientists to build qsar models using their own data sets . medchem studio a multi purpose cheminformatics software tool used for advanced data mining and de novo molecule design . dddplus a software tool for formulation scientists that simulates the in vitro disintegration and dissolution of solid dosage forms under different experimental conditions . medchem designer a chemical sketching tool that combines molecule drawing capabilities with admet property predictions . membraneplus a software program which simulates the in vitro permeability experiments commonly run in the pharmaceutical industry including caco 2 pampa and mdck cell lines . as of march 1 2015 all of the top 20 pharmaceutical companies along with the u.s. food and drug administration fda the centers for disease control and prevention cdc the national institutes of health nih the national cancer institute nci and the china food and drug administration cfda license the company s software . notes edit grbic s parojcic j ibric s djuric z. in vitro in vivo correlation for gliclazide immediate release tablets based on mechanistic absorption simulation . aaps pharmscitech . 2010 dec 23 . kuentz m nick s parrott n r thlisberger d. a strategy for preclinical formulation development using gastroplus as pharmacokinetic simulation tool and a statistical screening design applied to a dog study . eur j pharm sci . 2006 jan ; 27 1 91 9 . de buck ss sinha vk fenu la nijsen mj mackie ce gilissen ra . prediction of human pharmacokinetics using physiologically based modeling a retrospective analysis of 26 clinically tested drugs . drug metab dispos . 2007 oct ; 35 10 1766 80 . tubic grozdanis m bolger mb langguth p. application of gastrointestinal simulation for extensions for biowaivers of highly permeable compounds . aaps j. 2008 ; 10 1 213 26 . yamazaki s skaptason j romero d vekich s jones hm tan w wilner kd koudriakova t. prediction of oral pharmacokinetics of cmet kinase inhibitors in humans physiologically based pharmacokinetic model versus traditional one compartment model . drug metab dispos . 2010 nov 23 . heimbach t lakshminarayana sb hu w he h. practical anticipation of human efficacious doses and pharmacokinetics using in vitro and preclinical in vivo data . aaps j. 2009 sep ; 11 3 602 14 . allan g davis j dickins m gardner i jenkins t jones h webster r westgate h. pre clinical pharmacokinetics of uk 453 061 a novel non nucleoside reverse transcriptase inhibitor nnrti and use of in silico physiologically based prediction tools to predict the oral pharmacokinetics of uk 453 061 in man . xenobiotica . 2008 jun ; 38 6 620 40 . dearden jc . in silico prediction of aqueous solubility . expert opin . drug discov 1 2006 31 52 2006 . tetko iv and poda gi . property based logp prediction . in r. mannhold ed . molecular drug properties measurement and prediction pp . chapter 15 . weinheim germany wiley vch 2007 . mannhold r poda gi ostermann c tetko iv . calculation of molecular lipophilicity state of the art and comparison of log p methods on more than 96 000 compounds . 2008 j. pharm . sci . 98 3 861 93 . references edit simulations plus inc. san fernando valley business journal december 29 2010 simulations plus inc. new york times company information simulations plus inc. datamonitor company profiles via alacra store may 23 2008 external links edit u.s. fda licenses gastroplus tm . . business wire . 9 jan 2007 . retrieved 2008 08 01 . u.s. epa licenses simulations plus admet predictor tm software . . medical news today . 19 jun 2008 . retrieved 2008 08 01 . u.s. national institutes of health licenses simulations plus classpharmer tm software . . bnet . 30 aug 2007 . retrieved 2008 08 01 . retrieved from https en.wikipedia.org w index.php title simulations plus & oldid 712808073 categories companies based in los angeles county californiasimulation softwarecompanies listed on nasdaqhidden categories articles with a promotional tone from september 2012all articles with a promotional tone navigation menu personal tools not logged intalkcontributionscreate accountlog in namespaces article talk variants views read edit view history more search navigation main pagecontentsfeatured contentcurrent eventsrandom articledonate to wikipediawikipedia store interaction helpabout wikipediacommunity portalrecent changescontact page tools what links hererelated changesupload filespecial pagespermanent linkpage informationwikidata itemcite this page print export create a bookdownload as pdfprintable version languages add links this page was last modified on 31 march 2016 at 06 47 . text is available under the creative commons attribution sharealike license ; 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