founded 1999 headquarters oslo norway area served global key people erik agner ceo products fine chemicals website polypure.no polypure is a norwegian company that manufactures and markets monodisperse peg polyethylene glycol derivatives for applications in nanotechnology biotechnology and in pharmaceutical sciences . its headquarters are located in the oslo innovation center 1 oslo norway . the company has been in operation since 1999 . the compounds are produced using a proprietary purification technology called sample displacement chromatography sdc . 2 the technique exploits the correlation between molecular weight and binding strength of peg species . that is individual peg molecules bind to the matrix within a chromatography column at differing affinity depending on their molecular weight . because of this property when peg is applied to the top of a chromatography column strong binding species take possession of the first binding positions available and thereby force weaker binders to follow the liquid flow down the column to the next vacant positions . this results in the spatial separation of peg species within the column according to affinity and thereby molecular weight . monodisperse peg products are used as linkers or molecular tethers to join molecular entities as in cipriano and dunn 3 . they are also coupled to substances to make use of the hydrophilic property of peg to enhance water solubility or to facilitate penetration of a coupled substance through cell membranes 4 as well as to reduce immunogenicity of proteins used as therapeutic agents . the major shareholders in the company are erik agner co founder and ceo of the company and gamma group as . references edit hovedside forskningsparken us patent number 6245238 cipriano dj dunn sd . tethering polypeptides through bifunctional peg cross linking agents to probe protein function application to atp synthase . proteins . 2008 apr 28 . pmid 18442134 berna m dalzoppo d pasut g manunta m izzo l jones at duncan r veronese fm . novel monodisperse peg dendrons as new tools for targeted drug delivery synthesis characterization and cellular uptake . biomacromolecules . 2006 7 146 53 pmid 16398509 retrieved from https en.wikipedia.org w index.php title polypure & oldid 605103534 categories companies based in oslo navigation menu personal tools not logged intalkcontributionscreate accountlog in namespaces article talk variants views read edit view history more search navigation main pagecontentsfeatured contentcurrent eventsrandom articledonate to wikipediawikipedia store interaction helpabout wikipediacommunity portalrecent changescontact page tools what links hererelated changesupload filespecial pagespermanent linkpage informationwikidata itemcite this page print export create a bookdownload as pdfprintable version languages add links this page was last modified on 21 april 2014 at 04 19 . text is available under the creative commons attribution sharealike license ; additional terms may apply . by using this site you agree to the terms of use and privacy policy . wikipedia is a registered trademark of the wikimedia foundation inc. a non profit organization . privacy policy about wikipedia disclaimers contact wikipedia developers cookie statement mobile view