as nasdaq vphm industry healthcare biotechnology pharmaceutical company founded exton pennsylvania u.s. 1994 headquarters exton pennsylvania u.s. key people claude h. nash founding ceo vincent milano chairman and ceo products vancocin revenue 132 417 000 usd 2005 operating income 88 145 000 usd 2005 net income 113 705 000 usd 2005 number of employees 232 1 website www.viropharma.com viropharma incorporated was a pharmaceutical company that developed and sold drugs that addressed serious diseases treated by physician specialists and in hospital settings . the company focused on product development activities on viruses and human disease including those caused by cytomegalovirus cmv and hepatitis c virus hcv infections . it was purchased by shire in 2013 with shire paying around 4.2 billion for the company in a deal that was finalized in january 2014 . 2 viropharma was a member of the nasdaq biotechnology index and the s & p 600 . the company had strategic relationships with glaxosmithkline schering plough and sanofi aventis . viropharma acquired lev pharmaceuticals in a merger in 2008 . 3 4 contents 1 history 2 board of directors 3 management team 4 products 4.1 marketed products 4.2 pipeline 4.3 failed products 5 references 5.1 further references 6 external links history edit viropharma incorporated was founded in 1994 by claude h. nash chief executive officer mark a. mckinlay vice president research & development marc s. collett vice president discovery research johanna a. griffin vice president business development and guy d. diana vice president chemistry research . none of the founders are still with the company . in november 2014 shire plc acquired viropharma for 4.2 billion . 5 board of directors edit michel de rosen chairman since september 2002 president and chief executive officer since august 2000 director since may 2000 vincent j. milano president and chief executive officer since march 2008 director since march 2008 paul a. brooke director since february 2001 william d. claypool director since december 2003 michael r. dougherty director since january 2004 robert j. glaser director since august 1997 john r. leone director since january 2006 howard h. pien director since 2006 management team edit vincent j. milano president and chief executive officer daniel b. soland vice president chief operating officer thomas f. doyle vice president strategic initiatives colin broom vice president chief scientific officer robert g. pietrusko vice president global regulatory affairs and quality j. peter wolf vice president general counsel products edit marketed products edit vancocin pulvules hcl licensed from eli lilly in 2004 . 6 oral vancocin is an antibiotic for treatment of staphylococcal enterocolitis and antibiotic associated pseudomembranous colitis caused by clostridium difficile . pipeline edit maribavir is an oral antiviral drug candidate licensed from glaxosmithkline in 2003 for the prevention and treatment of human cytomegalovirus disease in hematopoietic stem cell bone marrow transplant patients . in february 2006 viropharma announced that the united states food and drug administration fda had granted the company fast track status for maribavir . in march 2006 the company announced that a phase ii study with maribavir demonstrated that prophylaxis with maribavir displays strong antiviral activity as measured by statistically significant reduction in the rate of reactivation of cmv in recipients of hematopoietic stem cell bone marrow transplants . in an intent to treat analysis of the first 100 days after the transplant the number of subjects who required pre emptive anti cmv therapy was statistically significantly reduced p value 0.051 to 0.001 in each of the maribavir groups compared to the placebo group 57 % for placebo vs. 15 % 30 % and 15 % for maribavir 100 mg twice daily 400 mg daily and 400 mg twice daily respectively . viropharma conducted a phase iii clinical study to evaluate the prophylactic use for the prevention of cytomegalovirus disease in recipients of allogeneic stem cell transplant patients . in february 2009 viropharma announced that the phase iii study failed to achieve its goal showing no significant difference between maribavir and a placebo in reducing the rate of cmv disease . 7 failed products edit main article pleconaril oral pleconaril was viropharma s first compound licensed from sanofi in 1995 . pleconaril is active against viruses in the picornavirus family . viropharma s first indication was for enteroviral meningitis but that indication was abandoned when the clinical trials did not demonstrate efficacy . in 2001 viropharma submitted a new drug application of pleconaril to the fda for the common cold . 8 on 2002 03 19 the fda antiviral advisory committee recommended that the company had failed to show adequate safety and the fda subsequently issued a not approvable letter . 9 in november 2003 viropharma licensed pleconaril to schering plough who are developing an intranasal formulation for the common cold and asthma exacerbations . schering plough development pipeline . in august 2006 schering plough started a phase ii clinical trial . references edit http finance.yahoo.com q pr s vphm shire buys viropharma for 4.2 billion to add orphan drug 11 11 2013 staff 2008 07 15 . viropharma to purchase lev for 442.9 m . genetic engineering & biotechnology news . gen news highlights . mary ann liebert . issn 1937 8661 . retrieved 2008 09 26 . lev pharmaceuticals investor relations . lev pharmaceuticals . retrieved 2009 04 08 . kitamura makiko 11 november 2013 . shire buys viropharma for 4.2 billion to add orphan drug . bloomberg . pollack andrew 2005 11 09 . crucial antibiotic rescues biotech maker s finances . new york times . retrieved 2007 09 20 . viropharma maribavir phase iii study missed goal ; shares plunge cnn money february 09 2009 freundlich naomi 2002 02 03 . on the trail of a cure for the common cold . new york times . retrieved 2007 09 20 . pollack andrew 2002 03 20 . f.d.a. panel opposes drug meant to treat cause of colds . new york times . retrieved 2007 09 20 . further references edit the long road ahead for viropharma motley fool 29 september 2006 mcdonald lc killgore ge thompson a et al. 2005 emergence of an epidemic toxin gene variant strain of clostridium difficile responsible for outbreaks in the united states between 2000 and 2004 n engl j med 353 2433 2441 1 u.s. centers for disease control and prevention report on severe clostridium difficile associated disease in populations previously at low risk four states 2005 2 lu h thomas s. 2004 . maribavir viropharma . curr opin investig drugs 5 898 906 fleischer r laessig k 2003 . safety and efficacy evaluation of pleconaril for treatment of the common cold . clin . infect . dis . 37 12 1722 . doi 10.1086 379830 . pmid 14689362 . hayden fg herrington dt coats tl kim k cooper ec villano sa liu s hudson s pevear dc collett m mckinlay m 2003 . efficacy and safety of oral pleconaril for treatment of colds due to picornaviruses in adults results of 2 double blind randomized placebo controlled trials . clin . infect . dis . 36 12 1523 32 . doi 10.1086 375069 . pmid 12802751 . companies portal external links edit viropharma.com v t e philadelphia area corporations including the delaware valley list of companies based in the philadelphia area philadelphia based fortune 500 corporations rank in the 2015 list comcast 43 aramark 207 crown holdings 318 delaware valley based fortune 500 corporations rank in the 2015 list amerisourcebergen 16 dupont 87 lincoln national 223 universal health services 324 campbell soup 342 ugi 349 burlington stores inc. 500 other notable philadelphia based businesses amoroso s beneficial bank chemtura day & zimmermann fmc corporation independence blue cross pennsylvania real estate investment trust pep boys philadelphia media network radian group urban outfitters notable philadelphia based professional partnerships ballard spahr blank rome cozen o connor dechert drinker biddle & reath duane morris morgan lewis & bockius pepper hamilton saul ewing white and williams other notable delaware valley based businesses actua corporation airgas alliedbarton ametek aqua america asplundh bentley systems brandywine realty trust boscov s carpenter technology cephalon chemours christiana care health system crozer keystone health system david s bridal epam systems enersys hamilton lane liberty property trust penn mutual penn national gaming rita s italian ice sei investments slm sungard susquehanna international group vanguard toll brothers triumph group unisys viropharma vishay intertechnology vwr wawa wilmington trust w. l. gore and associates wsfs bank notable delaware valley based us headquarters of foreign businesses aberdeen asset management ace agustawestland astrazeneca delaware investments glaxosmithkline ing group keystone foods sap america siemens medical shire pharmaceuticals subaru teva pharmacueticals td bank notable delaware valley based division headquarters of us corporations acme cerberus capital management centocor johnson & johnson colonial penn conseco delmarva power exelon gsi commerce ebay hercules ashland mab paints sherwin williams mcneil laboratories j & j neoware hewlett packard peco exelon qvc liberty media rohm and haas dow chemical sunoco energy transfer tasty baking flowers foods v t e pharmaceutical companies of the united states abbott laboratories acorda therapeutics actavis aderis pharmaceuticals adolor corporation alcon alexion pharmaceuticals alkermes allergan alza amgen amylin pharmaceuticals ariad pharmaceuticals aryx therapeutics avax technologies baxter international biocryst pharmaceuticals biogen biolex biovest biovista bradley pharmaceuticals bristol myers squibb cancervax century pharmaceuticals cephalon ceragenix pharmaceuticals combe incorporated cortex pharmaceuticals cotherix covance covidien cubist pharmaceuticals cutter laboratories cytosport cytrx danco laboratories dnaprint genomics epix pharmaceuticals eli lilly and company elorac endo pharmaceuticals ethicon endo surgery ethicon inc. forest laboratories galena biopharma genvec genentech genta gilead sciences hospira imclone systems institute for oneworld health intercept pharmaceuticals ista pharmaceuticals ivax corporation janssen biotech johnson & johnson kinetic concepts king pharmaceuticals kinray kv pharmaceutical leiner health products mallinckrodt martek biosciences corporation s. e. massengill company mckesson corporation mcneil laboratories melior discovery mentholatum merck & co. miles laboratories mylan myriad genetics naurex nereus pharmaceuticals northwest biotherapeutics norwich pharma services novabay pharmaceuticals nuvelo organon international ortho pharmaceutical ortho mcneil pharmaceutical osi pharmaceuticals ovation pharmaceuticals par pharmaceutical parke davis perrigo pfizer pharmaceutical product development prasco laboratories procter & gamble proteon therapeutics purdue pharma qualitest quark pharmaceuticals regeneron repros therapeutics rib x pharmaceuticals sarepta therapeutics savage laboratories schering plough g. d. searle & company sheffield pharmaceuticals smith kline & french spectrum pharmaceuticals sterling drug tanox tap pharmaceutical products tec laboratories teva pharmaceutical industries tiens biotech group titan pharmaceuticals trevena inc trubion upjohn upsher smith laboratories valeant pharmaceuticals ventria bioscience vertex pharmaceuticals verus pharmaceuticals vion pharmaceuticals inc. viropharma west pharmaceutical services wyeth zonite products corporation list of pharmaceutical companies retrieved from https en.wikipedia.org w index.php title viropharma & oldid 743893690 categories companies formerly listed on nasdaqpharmaceutical companies established in 1994biotechnology companies of the united statespharmaceutical companies of the united statescompanies in the nasdaq biotechnology indexcompanies based in chester county pennsylvaniaorphan drug companieslife sciences industryamerican companies established in 19941994 establishments in pennsylvaniacompanies disestablished in 20082008 disestablishments in pennsylvaniahidden categories use dmy dates from october 2010 navigation menu personal tools not logged intalkcontributionscreate accountlog in namespaces article talk variants views read edit view history more search navigation main pagecontentsfeatured contentcurrent eventsrandom articledonate to wikipediawikipedia store interaction helpabout wikipediacommunity portalrecent changescontact page tools what links hererelated changesupload filespecial pagespermanent linkpage informationwikidata itemcite this page print export create a bookdownload as pdfprintable version languages add links this page was last modified on 11 october 2016 at 21 47 . text is available under the creative commons attribution sharealike license ; 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