ecx otcqx epgny industry molecular diagnostics founded 1998 headquarters berlin germany ; seattle washington products epi procolon & epi prolung not available in the us . website www.epigenomics.com epigenomics is a molecular diagnostics company headquartered in berlin germany with a wholly owned subsidiary epigenomics inc. based in seattle wa . contents 1 history 2 focus 3 products 4 references 5 additional publications history edit epigenomics was founded in berlin germany in 1998 . around the same time orca biosciences was founded in seattle wa . the companies merged in 2000 and have focused on applying dna methylation based biomarkers to address medical needs . epigenomics became a publicly traded company with its listing on the frankfurt exchange in 2004 . the company maintains a work force in berlin as well as in seattle . focus edit epigenomics is focused on developing and marketing molecular diagnostics for oncology . the company has discovered dna methylation based biomarkers for a number of oncology related indications has developed enabling technologies for the analysis of methylation in blood and other body fluids and is bringing medically important products to the market . key contributions to biomarker science based on dna methylation include sept9 measurement in blood for detection of colon cancer . 1 2 3 shox2 measurement in lung fluid to aid in diagnosis of lung cancer . 4 pitx2 measurement in prostate tissue as a prognosis factor for prostate cancer . 5 the company continues to focus on discovering and validating dna methylation based biomarkers and developing the technology to make dna methylation testing a routine practice in the clinical laboratory . where possible the results of these efforts are shared with the scientific community as evidenced by 60 peer reviewed scientific publications over the past 10 years . products edit epigenomics has developed and launched two ce marked ivd products based on methylation biomarkers epi procolon a test to measure the methylation status of the sept9 promoter in plasma as an aid in early detection of colon cancer . epi prolung a test to measure the methylation status of the shox2 gene in bronchial lavage fluid to help in the workup of patients suspect to have lung cancer . these products are not currently available in the u.s. epigenomics has licensed the sept9 biomarker and certain dna methylation technologies to quest diagnostics and arup laboratories in the us as well as warnex laboratories in canada . these labs have independently launched laboratory developed tests for the sept9 biomarker and are providing this sept9 testing service to the medical community in the us and canada . although these tests were developed independently by the licensees and epigenomics therefore can not guarantee their performance the results of clinical validations by these companies are very similar to those obtained by epigenomics . epigenomics also has a strategic partnership with abbott molecular for the development of an ivd test kit based on the sept9 biomarker . abbott has launched this test as a ce marked ivd in europe under the brand name ms9 . references edit grutzmann r molnar b pilarsky c habermann jk schlag pm saeger hd miehlke s stolz t model f roblick uj bruch hp koch r liebenberg v devos t song x day rh sledziewski az lofton day c november 2008 . sensitive detection of colorectal cancer in peripheral blood by septin 9 dna methylation assay . plos one . 3 11 1 8 . doi 10.1371 journal.pone .0003759 . issn 1059 1524 . pmc 2582436 . pmid 19018278 . lofton day c model f devos t tetzner r distler j schuster m song x lesche r liebenberg v ebert m molnar b gr tzmann r pilarsky c sledziewski a 2008 . dna methylation biomarkers for blood based colorectal cancer screening . . clin chem . 54 2 414 423 . doi 10.1373 clinchem .2007.095992 . pmid 18089654 . devos t tetzner r model f weiss g schuster m distler j steiger kv gr tzmann r pilarsky c habermann jk fleshner pr oubre bm day r sledziewski az lofton day c 2009 . circulating methylated sept9 dna in plasma is a biomarker for colorectal cancer . . clin chem . 55 7 1337 1346 . doi 10.1373 clinchem .2008.115808 . pmid 19406918 . schmidt b liebenberg v dietrich d schlegel t kneip c seegebarth a flemming n seemann s distler j lewin j tetzner r weickmann s wille u liloglou t raji o walshaw m fleischhacker m witt c field jk november 2010 . shox2 dna methylation is a biomarker for the diagnosis of lung cancer based on bronchial aspirates . . bmc cancer . 3 10 600 . doi 10.1186 1471 2407 10 600 . issn 1471 2407 . pmc 2988753 . pmid 21047392 . banez l sun l van leenders gj wheeler tm bangma ch freedland sj ittmann mm lark al madden jf hartman a weiss g casta os v lez e november 2010 . multicenter clinical validation of pitx2 methylation as a prostate specific antigen recurrence predictor in patients with post radical prostatectomy prostate cancer . . j urol . 184 1 149 156 . doi 10.1016 j.juro .2010.03.012 . issn 1527 3792 . pmid 20478579 . additional publications edit payne s.r. 2010 . from discovery to the clinic the novel dna methylation biomarker msept9 for the detection of colorectal cancer in blood . . epigenomics . 2 4 575 585 . doi 10.2217 epi .10.35 . companies portal retrieved from https en.wikipedia.org w index.php title epigenomics ag & oldid 743189739 categories biotechnology companies of germanycompanies based in berlincompanies established in 1998 navigation menu personal tools not logged intalkcontributionscreate accountlog in namespaces article talk variants views read edit view history more search navigation main pagecontentsfeatured contentcurrent eventsrandom articledonate to wikipediawikipedia store interaction helpabout wikipediacommunity portalrecent changescontact page tools what links hererelated changesupload filespecial pagespermanent linkpage informationwikidata itemcite this page print export create a bookdownload as pdfprintable version languages deutsch edit links this 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