type privately held company industry life science manufacturing founded 1999 founder michael comb headquarters danvers massachusetts key people michael comb president and ceo roberto polakiewicz cso fenel eloi cfo coo products antibodies elisa kits chip kits proteomics kits number of employees 450 500 subsidiaries cell signaling technology japan k.k. cell signaling technology china limited cell signaling technology europe b.v. website www.cellsignal.com cell signaling technology inc. cst is a private company that develops and produces antibodies elisa kits chip kits proteomic kits and other related regents used to study the cell signaling pathways that impact human health . cst maintains an in house research program particularly in the area of cancer research and has published scientific papers in many peer reviewed journals . contents 1 history 2 research 3 references 4 external links history edit cell signaling technology inc. cst was founded in 1999 by scientists in the cell signaling group at new england biolabs neb . 1 originally housed in the cummings center beverly massachusetts cst moved to its current united states headquarters located at the former king s grant inn danvers massachusetts in late 2005 . 1 2 following extensive renovation 3 the u.s. green building council has certified the current headquarters as a leed leadership in energy and environmental design certified facility in 2007 . 4 in 2008 and 2009 cst expanded its overseas operations establishing subsidiary offices in the people s republic of china japan and the netherlands . 5 6 in 2013 cst moved its production group into an iso9001 certified facility in beverly massachusetts . the company has the capabilities to manufacture cgmp grade antibodies . cell signaling technology inc. cst was named as one of the top 100 places to work in a 2009 2013 survey published by the boston globe . 7 research edit in addition to product development and production cst is also involved in the development of new technologies for signaling analysis as well as mechanistic cell biology research particularly in the field of cancer research . cst scientists publish their findings in peer reviewed journals including nature cell biology cell molecular and cellular biology and journal of biological chemistry . 8 9 10 11 12 cst curates and maintains phosphositeplus a web based bioinformatics resource that details post translational modifications ptms in human mouse and rat proteins . the types of ptms curated include phosphorylation acetylation methylation ubiquitylation glycosylation etc. this freely accessible online resource is funded in part through grant support from the nih and most recently through the nih bd2k initiative . 13 14 references edit a b a lab with a view new research space reflects company s open research driven philosophy king s grant inn goes from hotel to biotech hq new room at the inn public buildings take the leed in new england cell signaling technology opens unit in japan cell signaling technology buys dutch distributor globe top 100 places to work wimberly h. ; brown j. r. ; schalper k. ; haack h. ; silver m. r. ; nixon c. ; bossuyt v. ; pusztai l. ; lannin d. r. ; rimm d. l. 2015 . pd l1 expression correlates with tumor infiltrating lymphocytes and response to neoadjuvant chemotherapy in breast cancer . cancer immunology research . 3 4 326 32 . doi 10.1158 2326 6066 . cir 14 0133 . pmid 25527356 . fan jun ; kang hee bum ; shan changliang ; elf shannon ; lin ruiting ; xie jianxin ; gu ting lei ; aguiar mike ; lonning scott ; chung tae wook ; arellano martha ; khoury hanna j. ; shin dong m. ; khuri fadlo r. ; boggon titus j. ; kang sumin ; chen jing 2014 . tyr 301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding and promotes the warburg effect . journal of biological chemistry . 289 38 26533 41 . doi 10.1074 jbc.m114 .593970 . pmc 4176253 . pmid 25104357 . li na ; fassl anne ; chick joel ; inuzuka hiroyuki ; li xiaoyu ; mansour marc r. ; liu lijun ; wang haizhen ; king bryan ; shaik shavali ; gutierrez alejandro ; ordureau alban ; otto tobias ; kreslavsky taras ; baitsch lukas ; bury leah ; meyer clifford a. ; ke nan ; mulry kristin a. ; kluk michael j. ; roy moni ; kim sunkyu ; zhang xiaowu ; geng yan ; zagozdzon agnieszka ; jenkinson sarah ; gale rosemary e. ; linch david c. ; zhao jean j. ; mullighan charles g. ; harper j. wade ; aster jon c. ; aifantis iannis ; von boehmer harald ; gygi steven p. ; wei wenyi ; look a. thomas ; sicinski piotr 2014 . cyclin c is a haploinsufficient tumour suppressor . nature cell biology . 16 11 1080 91 . doi 10.1038 ncb3046 . pmc 4235773 . pmid 25344755 . lawan ahmed ; zhang lei ; gatzke florian ; min kisuk ; jurczak michael j. ; al mutairi mashael ; richter patric ; camporez joao paulo g. ; couvillon anthony ; pesta dominik ; roth flach rachel j. ; shulman gerald i. ; bennett anton m. 2015 . hepatic mitogen activated protein kinase phosphatase 1 selectively regulates glucose metabolism and energy homeostasis . molecular and cellular biology . 35 1 26 40 . doi 10.1128 mcb .00503 14 . pmc 4295383 . pmid 25312648 . israelsen william j. ; dayton talya l. ; davidson shawn m. ; fiske brian p. ; hosios aaron m. ; bellinger gary ; li jie ; yu yimin ; sasaki mika ; horner james w. ; burga laura n. ; xie jianxin ; jurczak michael j. ; depinho ronald a. ; clish clary b. ; jacks tyler ; kibbey richard g. ; wulf gerburg m. ; di vizio dolores ; mills gordon b. ; cantley lewis c. ; vander heiden matthew g. 2013 . pkm2 isoform specific deletion reveals a differential requirement for pyruvate kinase in tumor cells . cell . 155 2 397 409 . doi 10.1016 j.cell .2013.09.025 . pmc 3850755 . pmid 24120138 . hornbeck peter v. ; zhang bin ; murray beth ; kornhauser jon m. ; latham vaughan ; skrzypek elzbieta 2015 . phosphositeplus 2014 mutations ptms and recalibrations . nucleic acids res . 43 1 d512 20 . doi 10.1093 nar gku1267 pmc .4383998 . pmid 25514926 . cell signaling technology announces the availability of phosphoscan profiling technology and phosphosite knowledgebase to academic researchers press release . cell signaling technology . october 31 2007 . retrieved october 24 2015 . external links edit cell signaling technology inc. web site cell signaling technology china limited web site cell signaling technology europe b.v. web site cell signaling technology japan k.k. web site phosphositeplus web site retrieved from https en.wikipedia.org w index.php title cell signaling technology & oldid 743027469 categories technology companies established in 1999companies based in beverly massachusettsbiotechnology companies of the united stateslife science companies based in massachusettsresearch support companies1999 establishments in massachusettscompanies based in danvers massachusetts navigation menu personal tools not logged intalkcontributionscreate accountlog in namespaces article talk variants views read edit view history more search navigation main pagecontentsfeatured contentcurrent eventsrandom articledonate to wikipediawikipedia store interaction helpabout wikipediacommunity portalrecent changescontact page tools what links hererelated changesupload filespecial pagespermanent linkpage informationwikidata itemcite this page print export create a bookdownload as pdfprintable version languages deutsch edit links this page was last modified on 7 october 2016 at 09 43 . text is available under the creative commons attribution sharealike license ; 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