founded 2003 founders sridhar govindarajan claes gustafsson jeremy minshull jon ness headquarters newark california u.s. products gene synthesis protein engineering protein production bioinformatics website www.dna20.com dna2 .0 provides products and services for life science and synthetic biology research . dna2 .0 also provides free access to research tools such as gene designer dna atlas and a grna designer . contents 1 the company 2 research tools 3 partnerships 4 patents 5 references 6 external links the company edit dna2 .0 was founded in 2003 in menlo park california . the company is privately held 1 and continues to have all research development and production in california currently in their 50 000 sq ft newark facility . 2 it began and continues as a gene synthesis and protein engineering provider to academia government and the pharmaceutical chemical agricultural and biotechnology industries . gene synthesis rapidly replaced molecular cloning for many academic and corporate labs as foundries for the biotechnology age allowing made to order genes for biological research . 3 dna2 .0 was featured on the pbs show nova sciencenow 4 to show how genes are created synthetically in a lab . in 2008 the company supplied some of the dna stretches used to create a synthetic bacterial genome . 5 dan rather reports included dna2 .0 in their episode on synthetic biology 6 and how it is solving some of the most important problems facing the world . 6 in 2009 the scientist named the codon design algorithms 7 now trademarked as genegps developed by dna2 .0 as one of the top 10 innovations of the year for life sciences . 8 dna2 .0 developed the electra vector system a universal cloning system that utilizes the type iis restriction enzyme sapi and t4 dna ligase in a single tube reaction . 9 dna2 .0 has made some molecular components such as synthetic fluorescent proteins available in open access collections of dna parts biobricks foundation . 10 dna2 .0 is a founding member of the international gene synthesis consortium igsc to promote biosecurity in the gene synthesis industry . 11 12 there are over 1 200 13 published scientific articles using dna2 .0 products and or services of which 44 14 include company employees as an author s . research tools edit gene designer is a free bioinformatics software package . 15 16 it is used by molecular biologists to design 17 clone and validate genetic sequences . 18 a free grna design tool with scoring algorithms for crispr . dna atlas is a free plasmid mapping tool to show features such as promoters markers restriction sites and open reading frames in any dna vector sequence . the online bioinformatics toolbox was selected as a best of the web by genetic engineering news . 19 partnerships edit the perelman school of medicine at the university of pennsylvania will use the genegps technology developed by dna2 .0 primarily to support the gene therapy program s work on hiv 1 vaccine development by optimizing in vivo protein expression . 20 21 the infection and immunity research centre at st. george s university of london and dna2 .0 partnered to develop plant based pharmaceuticals . 22 adimab llc . and dna2 .0 employ an alliance in the area of antibody discovery and biomanufacturing via the design and construction of antibody libraries . cytovance biologics utilizes genegps from dna2 .0 as part of their keystone expression system for microbial strain development for successful biomanufacturing . archer daniels midland company applies dna2 .0 s proprietary protein engineering technology proteingps to adm s industrial enzyme engineering processes . 23 dna2 .0 is a sponsor of biobuilder a resource for hands on activities and informative animations on synthetic biology for middle school and high school students and teachers ; founded by dr. natalie kuldell at mit . patents edit us 9290552 minshull & theodorou fluorescent and colored proteins and methods for using them issued march 22 2016 us 9206433 minshull ; ness & theodorou methods compositions and kits for a one step dna cloning system issued december 8 2015 us 9102944 ness & minshull methods compositions and kits for one step dna cloning using dna topoisomerase issued august 11 2015 us 8975042 minshull & theodorou fluorescent and colored proteins and methods for using them issued march 10 2015 us 8825411 govindarajan ; minshull & ness design synthesis and assembly of synthetic nucleic acids issued september 2 2014 us 8635029 gustafsson ; govindarajan & minshull systems and methods for biopolymer engineering issued january 21 2014 us 8412461 gustafsson ; govindarajan & minshull systems and methods for antibody engineering issued april 2 2013 us 8401798 welch & gustafsson systems and methods for constructing frequency lookup tables for expression systems issued march 19 2013 us 8323930 ness & minshull methods compositions and kits for one step dna cloning using dna topoisomerase issued december 4 2012 us 8158391 gross ; lu & ness et al. production of an . alpha . carboxyl . omega . hydroxy fatty acid using a genetically modified candida strain issued september 28 2010 us 8126653 welch & gustafsson synthetic nucleic acids for expression of encoded proteins issued february 28 2012 us 8005620 gustafsson ; govindarajan & minshull systems and methods for biopolymer engineering issued august 23 2011 us 7805252 gustafsson ; govindarajan & ness et al. systems and methods for designing and ordering polynucleotides issued september 28 2010 us 7561973 welch & gustafsson methods for determining properties that affect an expression property value of polynucleotides in an expression system issued july 14 2009 us 7561972 welch & gustafsson synthetic nucleic acids for expression of encoded proteins issued july 14 2009 references edit duan mary october 18 2009 . gene synthesis it s no strain for dna 2.0 . silicon valley business journal . san jose ca . dna2 .0 builds state of the art bioproduction facility in newark california . mercurynews.com . the san jose mercury news . retrieved 22 march 2016 . pollack september 12 2007 . how do you like your genes biofabs take orders . the new york times . new york . artificial life . nova sciencenow . october 18 2005 . pbs . pollack january 24 2008 . scientists take new step toward man made life . the new york times . new york . a b cutting edge . dan rather reports . april 30 2013 . axs tv . welch ; govindarajan ; ness ; villalobos ; gurney ; minshull ; gustafsson september 14 2009 . design parameters to control synthetic gene expression in escherichia coli . . plos one . 4 9 e7002 . doi 10.1371 journal.pone .0007002 . pmc 2736378 . pmid 19759823 . 2009 top 10 innovations . the scientist . 23 12 41 52 . december 1 2009 . whitman ; gore ; ness ; theodorou ; minshull june 2013 rapid scarless cloning of gene fragments using sapi t4 dna ligase and the dna2 .0 electra vector system pdf neb expressions ii 8 ledford heidi july 4 2013 . bioengineers look beyond patents . nature . macmillan publishers limited . 499 16 17 . doi 10.1038 499016a . hayden erika check november 18 2009 . gene makers form security coalition . nature . doi 10.1038 news .2009.1095 . gene synthesis firms set up biosecurity protocol genetic engineering & biotechnology news november 18 2009 literature database search all . april 29 2016 . literature database search author affiliation dna2 .0 . april 29 2016 . villalobos alan ; ness jon e ; gustafsson claes ; minshull jeremy ; govindarajan sridhar 2006 . gene designer a synthetic biology tool for constructing artificial dna segments . bmc bioinformatics . 7 285 . doi 10.1186 1471 2105 7 285 . pmc 1523223 . pmid 16756672 . villalobos alan ; welch mark ; minshull jeremy 2012 . in silico design of functional dna constructs . gene synthesis . methods in molecular biology . 852 197 213 . doi 10.1007 978 1 61779 564 0 15 . isbn 978 1 61779 563 3 . pmid 22328435 . welch m ; villalobos a ; gustafsson c ; minshull j 2011 . designing genes for successful protein expression . methods in enzymology . 498 43 66 . doi 10.1016 b978 0 12 385120 8.00003 6 . pmid 21601673 . dance amber july 1 2012 . mover over mother nature . . the scientist . best of the web . genetic engineering news . april 15 2007 . optimizing gene expression with dna2 .0 technology . . gen. november 14 2012 . mcenery regina february 4 2013 delivering the dna vax the bulletin on aids vaccine research 11 1 cohen bryan december 24 2013 . dna2 .0 announces biopharmaceutical partnership with st. george s . vaccine news . adm and dna2 .0 enter into protein engineering technology access and service agreement . . san jose mercury news . san jose ca . november 17 2014 . external links edit www.dna20.com genedesigner retrieved from https en.wikipedia.org w index.php title dna2 .0 & oldid 731793375 categories research support companiesbiotechnology companies of the united statestechnology companies based in the san francisco bay areacompanies based in silicon valley navigation menu personal tools not logged intalkcontributionscreate accountlog in namespaces article talk variants views read edit view history more search navigation main pagecontentsfeatured contentcurrent eventsrandom articledonate to wikipediawikipedia store interaction helpabout wikipediacommunity portalrecent changescontact page tools what links hererelated changesupload filespecial pagespermanent linkpage informationwikidata itemcite this page print export create a bookdownload as pdfprintable version languages add links this page was last modified on 27 july 2016 at 15 20 . text is available under the creative commons attribution sharealike license ; 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