simulation founded sheffield uk 2001 products simcyp population based adme simulator simcyp paediatric simcyp rat website www.simcyp.com simcyp limited is a research based company which provides modelling and simulation software to the pharmaceutical industry for use during drug development . simcyp is based in sheffield uk . simcyp s simulators allow in silico prediction of drug absorption distribution metabolism and excretion adme and potential drug drug interactions . contents 1 research and development 2 background 3 simulator platforms 4 references 5 external links research and development edit simcyp s r & d activities focus on the development of algorithms along with population and drug databases for modelling and simulation m & s of the absorption and disposition of drugs in patients and specific subgroups of patients across different age ranges . the simcyp models use experimental data generated routinely during pre clinical drug discovery and development from in vitro enzyme and cellular systems as well as any relevant physico chemical attributes of the drug and dosage forms . 1 some details of the scientific background to simcyp approaches can be found in recent publications . 2 3 4 5 background edit simcyp originally formed as a spin out company from the university of sheffield uk . the company operates the simcyp consortium of pharmaceutical and biotechnology companies . the consortium acts as a steering committee guiding scientific research and development at simcyp . there is also close collaboration with regulatory bodies the u.s. food and drug administration swedish medical products agency nam ecvam and academic centres of excellence worldwide within the framework of the consortium . simulator platforms edit simcyp population based adme simulator 6 simcyp paediatric simcyp rat simcyp dog simcyp mouse references edit rostami hodjegan a tucker gt february 2007 . simulation and prediction of in vivo drug metabolism in human populations from in vitro data . nature reviews drug discovery . 6 2 140 8 . doi 10.1038 nrd2173 . pmid 17268485 . yang j jamei m yeo kr tucker gt rostami hodjegan a october 2007 . prediction of intestinal first pass drug metabolism . curr . drug metab . 8 7 676 84 . doi 10.2174 138920007782109733 . pmid 17979655 . yang j jamei m yeo kr tucker gt rostami hodjegan a july 2007 . theoretical assessment of a new experimental protocol for determining kinetic values describing mechanism time based enzyme inhibition . eur j pharm sci . 31 3 4 232 41 . doi 10.1016 j.ejps .2007.04.005 . pmid 17512176 . perrett hp et al. 2007 . disparity in holoprotein apoprotein ratios of different standards used for immunoquantification of hepatic cytochrome p450 enzymes . . drug metabolism & disposition . 35 10 1733 1736 . doi 10.1124 dmd .107.015743 . pmid 17600083 . yang j jamei m yeo kr rostami hodjegan a tucker gt march 2007 . misuse of the well stirred model of hepatic drug clearance . drug metab . dispos . 35 3 501 2 . doi 10.1124 dmd .106.013359 . pmid 17325025 . jamei m marciniak s feng k barnett a tucker g rostami hodjegan a february 2009 . the simcyp r population based adme simulator . expert opin drug metab toxicol . 5 2 211 223 . doi 10.1517 17425250802691074 . pmid 19199378 . external links edit http www.simcyp.com retrieved from https en.wikipedia.org w index.php title simcyp & oldid 723889682 categories software companies of the united kingdom navigation menu personal tools not logged intalkcontributionscreate accountlog in namespaces article talk variants views read edit view history more search navigation main pagecontentsfeatured contentcurrent eventsrandom articledonate to wikipediawikipedia store interaction helpabout wikipediacommunity portalrecent changescontact page tools what links hererelated changesupload filespecial pagespermanent linkpage informationwikidata itemcite this page print export create a bookdownload as pdfprintable version languages add links this page was last modified on 5 june 2016 at 22 06 . text is available under the creative commons attribution sharealike license ; additional terms may apply . by using this site you agree to the terms of use and privacy policy . wikipedia is a registered trademark of the wikimedia foundation inc. a non profit organization . privacy policy about wikipedia disclaimers contact wikipedia developers cookie statement mobile view