plc former type public traded as nyse eln industry biotechnology fate acquired by perrigo founded athlone county roscommon ireland 1969 defunct 2013 headquarters dublin ireland key people robert ingram chairman kelly martin ceo products prialt ziconotide nanocrystal technology in pipeline tysabri natalizumab azactam aztreonam for injection usp maxipime cefepime hydrochloride for injection revenue 0.2 million usd 2012 1 operating income 366.9 million usd 2012 1 net income 363.9 million usd 2012 1 website elan.com lan corporation plc was a major drugs firm based in dublin ireland which had major interests in the united states . it was listed on the new york stock exchange as eln the irish stock exchange as eln.i and the london stock exchange as eln.l . in 2013 the company merged with perrigo to form perrigo company plc. 2 contents 1 history 2 products in development 3 references 4 external links history edit the company was founded in ireland in 1969 . in the late 1990s its value on the irish stock exchange reached over 20bn . however in 2002 an accounting scandal and investor reactions to the global slump caused a major devaluation resulting in a share price slump of over 90 % . 3 since then the company has regained its growth path under the reign of a new american ceo kelly martin . 4 in july 2010 lan was fined 203m for its marketing of epilepsy drugs . 5 in february 2013 lan decided to dispose of the rights to sell tysabri to biogen idec for 3.25 billion . 6 products in development edit in neurology lan is focused on building upon its research and experience in the area of neuropathologies such as alzheimer s disease where the company s efforts include programs focused on small molecule inhibitors of beta secretase and gamma secretase enzymes whose actions are thought to affect the accumulation of the amyloid plaques found in the brains of patients with alzheimer s disease . an example of such a molecule is semagacestat . 7 lan is also studying other neurodegenerative diseases such as parkinson s disease . lan in collaboration with wyeth is currently conducting a phase iii clinical trial for bapineuzumab an experimental humanized monoclonal antibody with a targeted indication of immunotherapeutic treatment of mild to moderate alzheimer s disease . this humanized monoclonal antibody is designed and engineered to clear the neurotoxic beta amyloid peptide that accumulates in the brains of patients with alzheimer s disease . although initial results from an earlier phase ii clinical trial presented in july 2008 were inconclusive lan is hopeful that bapineuzumab will prove successful in the treatment of this disease . 8 in autoimmune diseases lan s primary emphasis is studying cell trafficking to discover ways to provide disease modifying therapies for autoimmune diseases such as rheumatoid arthritis multiple sclerosis and inflammatory bowel disease . research efforts are also focused on physiological and neuropathic pain . previously named antegren natalizumab is a drug co marketed by biogen idec and lan as tysabri . tysabri is a monoclonal antibody that inhibits immune cells from crossing blood vessel walls to reach various tissues including the brain . it has proven efficacy in the treatment of two serious autoimmune disorders multiple sclerosis and crohn s disease . 9 references edit a b c annual report 2012 perrigo company plc completes acquisition of lan corporation plc press release . perrigo . december 18 2013 . archived from the original on february 22 2014 . retrieved february 21 2014 . ireland s troubled lan corp. says sec is investigating its accounting practices ap 7 february 2002 business person of the month kelly martin ceo elan business & finance may 2011 insideireland.ie elan fined 203m over drug marketing elan fined 203m over drug marketing 16 july 2010 . accessed 19 july 2010 . biogen to pay elan 3.25 billion for full tysabri rights bloomberg 6 february 2013 lilly halts alzheimer s drug development pm live elan wyeth s alzheimer s angst builds as rivals fail bloomberg 20 july 2009 tysabri label change to target use . bloomberg.com . 20 january 2012 . external links edit official website retrieved from https en.wikipedia.org w index.php title lan & oldid 737254507 categories athlonepharmaceutical companies of irelandmanufacturing companies based in dublin city companies formerly listed on the irish stock exchangecompanies formerly listed on the london stock exchangecompanies formerly listed on the new york stock exchange navigation menu personal tools not logged intalkcontributionscreate accountlog in namespaces article talk variants views read edit view history more search navigation main pagecontentsfeatured contentcurrent eventsrandom articledonate to wikipediawikipedia store interaction helpabout wikipediacommunity portalrecent changescontact page tools what links hererelated changesupload filespecial pagespermanent linkpage informationwikidata itemcite this page 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