no other articles link to it . please introduce links to this page from related articles ; try the find link tool for suggestions . december 2012 regulus therapeutics inc. type public industry biotechnology founded september 2007 by alnylam pharmaceuticals nasdaq alny and isis pharmaceuticals nasdaq isis headquarters san diego california usa key people kleanthis g. xanthopoulos ph.d. president and ceo neil w. gibson ph.d. cso products microrna therapeutics number of employees 54 website www.regulusrx.com regulus therapeutics inc. or regulus nasdaq rgls is a biopharmaceutical company focused on the development of microrna based drugs targeting fibrosis metabolism and cardiovascular diseases cancer hcv and immune related diseases . regulus was established in september 2007 by alnylam pharmaceuticals and isis pharmaceuticals . 1 contents 1 microrna explained 2 anti mir therapeutics 3 strategic alliances 4 research collaborations 5 patents 6 references 7 external links microrna explained edit micrornas are small naturally occurring rna molecules typically 20 to 25 nucleotides in length that do not encode proteins but instead have evolved to regulate gene expression . 2 3 anti mir therapeutics edit anti mir therapeutics inhibit specific microrna targets . animal models showed that modulating micrornas through anti mirs effectively regulates biological processes and provides therapeutic benefit to cardiac dysfunction cancer and hepatitis c virus infection . administration of anti mir oligonucleotides is possible through local or parenteral injection . 4 strategic alliances edit in april 2008 regulus and glaxosmithkline gsk entered into a microrna focused strategic alliance for the discovery development and commercialization of novel microrna targeted therapeutics to treat inflammatory diseases such as rheumatoid arthritis . in february 2010 regulus and gsk announced a new collaboration to develop and commercialize microrna therapeutics targeting microrna 122 mir 122 for the treatment of hepatitis c hcv infection . most recently multi national pharmaceutical giant sanofi aventis awarded regulus with the largest microrna partnership to date targeting fibrosis . 2 research collaborations edit regulus has active collaborations with leading academic researchers from over 30 academic research laboratories globally . 1 patents edit regulus has more than 900 patents and patent applications 600 of which cover the method of use chemical modification and administration of oligonucleotides to address specific targets . 5 references edit a b hutton david june 2011 . omics & systems biology surf s up for micrornas . drug discovery news . cs1 maint multiple names authors list link a b senese mike october 2010 . the miracle of microrna . sandiegomagazine . liszewski kathy may 15 2011 . mirna drugs close in on clinical debut . genetic engineering & biotechnology news . steffy kevin ; allerson charles ; bhat balkrishen may 2011 . perspectives in mictorna therapeutics . pharmaceutical technology . flanagan michael june 2010 . a handful would be fine pdf . biocentury . external links edit regulus therapeutics official website rayner katey j. ; sheedy frederick j. ; esau christine c. ; hussain farah n. ; temel ryan e. ; parathath saj ; van gils janine m. ; rayner alistair j. ; et al. 2011 . antagonism of mir 33 in mice promotes reverse cholesterol transport and regression of atherosclerosis . journal of clinical investigation . 121 7 2921 31 . doi 10.1172 jci57275 . pmc 3223840 . pmid 21646721 . trajkovski mirko ; hausser jean ; soutschek j rgen ; bhat bal ; akin akinc ; zavolan mihaela ; heim markus h. ; stoffel markus 2011 . micrornas 103 and 107 regulate insulin sensitivity . nature . 474 7353 649 53 . doi 10.1038 nature10112 . pmid 21654750 . gabriely g. ; yi m. ; narayan r. s. ; niers j. m. ; wurdinger t. ; imitola j. ; ligon k. l. ; kesari s. ; et al. 2011 . human glioma growth is controlled by microrna 10b . cancer research . 71 10 3563 72 . doi 10.1158 0008 5472 . can 10 3568 . pmc 3096675 . pmid 21471404 . boldin m. p. ; taganov k. d. ; rao d. s. ; yang l. ; zhao j. l. ; kalwani m. ; garcia flores y. ; luong m. ; et al. 2011 . mir 146a is a significant brake on autoimmunity myeloproliferation and cancer in mice . journal of experimental medicine . 208 6 1189 1201 . doi 10.1084 jem .20101823 . pmc 3173243 . pmid 21555486 . park jong kook ; henry jon c. ; jiang jinmai ; esau christine ; gusev yuriy ; lerner megan r. ; postier russell g. ; brackett daniel j. ; schmittgen thomas d. 2011 . mir 132 and mir 212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor . biochemical and biophysical research communications . 406 4 518 23 . doi 10.1016 j.bbrc .2011.02.065 . pmc 3069485 . pmid 21329664 . thum thomas ; chau nelson ; bhat balkrishen ; gupta shashi kumar ; linsley peter s. ; bauersachs johann ; engelhardt stefan 2011 . comparison of different mir 21 inhibitor chemistries in a cardiac disease model . journal of clinical investigation . 121 2 461 2 . doi 10.1172 jci45938 . chau b. nelson ; brenner david a. 2011 . what goes up must come down the emerging role of microrna in fibrosis . hepatology . 53 1 4 6 . doi 10.1002 hep .24071 . pmid 21254156 . retrieved from https en.wikipedia.org w index.php title regulus therapeutics & oldid 723833204 categories pharmaceutical companies of the united stateshidden categories cs1 maint multiple names authors listorphaned articles from december 2012all orphaned articles navigation menu personal tools not logged intalkcontributionscreate accountlog in namespaces article talk variants views read edit view history more search navigation main pagecontentsfeatured contentcurrent eventsrandom articledonate to wikipediawikipedia store interaction helpabout wikipediacommunity portalrecent changescontact page tools what links hererelated changesupload filespecial pagespermanent linkpage informationwikidata itemcite this page print export create a bookdownload as pdfprintable version languages add links this page was last modified on 5 june 2016 at 15 28 . text is available under the creative commons attribution sharealike license ; additional terms may apply . by using this site you agree to the terms of use and privacy policy . wikipedia is a registered trademark of the wikimedia foundation inc. a non profit organization . privacy policy about wikipedia disclaimers contact wikipedia developers cookie statement mobile view