traded aktieselskab traded as nasdaq copenhagen bava industry biotechnology founded 1994 headquarters kvistg rd denmark redwood city california and martinsried germany key people paul chaplin president and ceo 1 gerard van odijk chairman 2 products imvanex number of employees 409 end 2015 422 end 2014 3 16 website www.bavarian nordic.com bavarian nordic is a biotechnology company specializing in research development and manufacture of active cancer immunotherapies and vaccines for infectious diseases . the company is headquartered in kvistgaard denmark a town in helsing r municipality where it also operates a commercial scale manufacturing facility . research and development facilities are located in redwood city california usa and martinsried germany . the company uses viral vectors in its research and development . contents 1 technologies 1.1 mva bn 1.2 vaccinia fowlpox tricom 2 ebola vaccine development and production 3 pipeline 4 references 5 external links technologies edit mva bn edit mva bn is a proprietary technology developed by bavarian nordic . it is derived from the modified vaccinia ankara virus . mva bn is characterized by the inability to replicate in human cells 4 contrary to other vaccinia based vaccines which may replicate in humans thus potentially causing severe and life threatening side effects . developed as the non replicating smallpox vaccine imvamune it is approved in canada 5 and in the european union where it is marketed as imvanex . 6 the vaccine is being supplied for emergency use to the u.s. strategic national stockpile as well as other government stockpiles . registration studies for the approval in the u.s. are currently underway . vaccinia fowlpox tricom edit a second poxvirus based technology is employed in most of the company s cancer immunotherapies and was in licensed as part of a collaboration with the national cancer institute nci . vaccinia fowlpox tricom is a sequential prime boost therapy based on vaccinia and fowlpox in combination with three co stimulatory molecules tricom . the poxvirus based immunotherapy can be modified to encode different tumor associated antigens such as prostate specific antigen psa carcinoembryonic antigen cea and or mucin 1 muc1 which are all tumor markers that are overexpressed in various cancers . this technology forms the basis of the company s lead oncology product candidates prostvac and cv 301 . prostvac is an active immunotherapy candidate currently the subject of a global phase 3 clinical study prospect 7 in men with asymptomatic or minimally symptomatic castration resistant prostate cancer . ebola vaccine development and production edit the company has worked for several years with the niaid 8 on the development of a filovirus vaccine for ebola and marburg hemorrhagic fever diseases . in october 2014 following a successful pre clinical demonstration of the combination vaccine regimen of its multivalent mva bn filovirus vaccine and crucell janssen s advac technology based on adenoviral vectors bavarian nordic joined efforts with crucell holland b.v. one of the janssen pharmaceuticals companies of johnson & johnson to develop and manufacture this vaccine regimen intended for emergency use to help contain the outbreak in west africa . 9 10 11 in january 2015 the company had produced the first 400 000 doses of the vaccine and the first clinical trial of the vaccine regimen was initiated in the uk with additional trials planned in the us and africa . 12 pipeline edit bavarian nordic s pipeline as of june 2016 . 13 product indication phase imvanex smallpox approved prostvac prostate cancer iii mva bn filo ebola and marburg virus iii cv 301 bladder cancer ii mva bn brachyury solid tumors i mva bn rsv rsv i mva bn hpv chronic hpv infection preclinical in addition the company has multiple pre clinical projects based on its mva bn technology targeting infectious diseases . references edit management . bavarian nordic . retrieved 2014 10 29 . self published source board of directors . bavarian nordic . archived from the original on 2015 04 07 . retrieved 2015 04 07 . self published source annual report 2015 pdf . bavarian nordic . retrieved 2016 04 07 . self published source kennedy js greenberg rn 9 january 2014 . imvamune modified vaccinia ankara strain as an attenuated smallpox vaccine . expert reviews of vaccines . 8 1 13 24 . doi 10.1586 14760584.8.1.13 . pmid 19093767 . subscription required help . products for human use . submission 144762 . register of innovative drugs . health canada . 13 june 2014 . 144762 submission number . archived from the original on 17 june 2014 . retrieved 2014 06 26 . imvanex . human medicines . european medicines agency . 27 may 2016 . retrieved 2016 06 12 . a randomized double blind phase 3 efficacy trial of prostvac v f gm csf in men with asymptomatic or minimally symptomatic metastatic castrate resistant prostate cancer prospect . clinicaltrials.gov . u.s. national institutes of health . retrieved 2014 06 26 . infectious diseases filovirus vaccine . bavarian nordic . retrieved 2014 10 29 . bavarian nordic enters licensing and supply agreement with janssen on mva bn ebola vaccine . bavarian nordic . 2014 10 22 . retrieved 2014 10 29 . brief bavarian nordic to expand collaboration with janssen . reuters brief . reuters . 2014 10 23 . retrieved 2014 10 29 . johnson & johnson plans ebola vaccine testing . ap.org . ap news . 2014 10 22 . retrieved 2014 10 29 . j & j bavarian nordic start clinical tests in ebola vaccine race . reuters . reuters . 2015 01 06 . retrieved 2015 01 12 . pipeline . bavarian nordic . retrieved 2016 06 17 . external links edit official website retrieved from https en.wikipedia.org w index.php title bavarian nordic & oldid 742992321 categories pharmaceutical companies of denmarkbiotechnology companies of denmarkcompanies established in 1994life science companies based in copenhagencompanies based in helsing r municiality1994 establishments in denmarkhidden 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