biotechnology founded 1993 headquarters petaluma california key people ronald cook ph.d founder and ceo website biosearchtech.com biosearch technologies inc. is a closely held biotechnology company headquartered in petaluma california . 1 this company is vertically integrated and specializes in custom synthesized oligonucleotides for qpcr cgmp oligos for molecular diagnostics and dna rna synthesis reagents . their gmp good manufacturing practice manufacturing facility is located in novato california . in 2015 the company lgc agreed to acquire biosearch technologies based on the two company s complimentary product lines . 2 contents 1 products & services 1.1 black hole quencher dyes 1.2 fluorogenic probes and primers 1.3 valupanel reagents 1.4 stellaris fish probes 1.5 design service realtimedesign 2 history 2.1 founding 2.2 mergers and acquisitions 2.3 recognition in pcr research 3 references 4 external links products & services edit black hole quencher dyes edit in 2000 biosearch technologies developed a dark quencher known as the black hole quencher bhq dyes which has become an industry standard product and is currently licensed out to a number of other oligonucleotide manufacturers biotechnology and molecular diagnostic manufacturers . the series of black hole quencher dyes have no native fluorescence high signal to noise ratios providing greater sensitivity and exceptional coupling efficiency . 3 bhq dyes are able to quench the entire visible spectrum and near ir spectrum allowing for a broader range of fluorogenic reporter dyes which makes the black hole quenchers ideal for multiplexing assays . 4 fluorogenic probes and primers edit the research team at biosearch technologies also developed other fluorescent dyes such as the cal fluor quasar and pulsar series of dyes which emit fluorescence from 500 700 nanometers . equipped with the various technology in fluorescent dyes and quenchers much of biosearch technologies business comes from the design and manufacture of custom probes and primers which are commonly used for genomic applications such as quantitative pcr and snp genotyping . valupanel reagents edit during the 2009 h1n1 pandemic biosearch technologies became the first to license from the cdc the h1n1 influenza and influenza a sub typing panel signatures . they would later obtain a license for the pdm h1n1 signatures as well . with these licenses from the cdc biosearch technologies manufactured probes and primers to discriminate the various flu signatures as part of their valupanel reagents product line . in 2013 biosearch responded to the avian influenza a h7n9 outbreak in china by providing an h7n9 detection panel . stellaris fish probes edit for more details on the stellaris fish technology see fluorescence in situ hybridization stellaris fish probes . in 2010 biosearch technologies acquired an exclusive license to the single molecule fish technology developed by scientists at university of medicine and dentistry of new jersey . 5 the technology is now branded as stellaris fish and is a method of detecting and quantifying mrna and other long rna molecules in cell culture or tissue samples . the technology is a refinement of earlier rna ish technologies and uses multiple single labeled dna oligonucleotide probes to increase sensitivity and specificity . design service realtimedesign edit biosearch technologies offers a free web based design service known as realtimedesign rtd equipped with comprehensive algorithms that allow the software to model and propose quantitative pcr and snp genotyping assays . realtimedesign is meant to help scientists craft custom oligonucleotides averaging 99 % in amplification efficiency through a series of different features offered by the software . some of those features include a direct link to ncbi and blast databases as well as a selection of user modifiable parameters . 6 history edit founding edit although biosearch technologies was founded in 1993 its roots can be traced back to 1979 when it was preceded by dr. ronald cook s first company biosearch inc. biosearch inc. experienced 9 years of dna synthesis instrumentation and chemistry by playing a key role in engineering and manufacturing one of the first automated solid phase dna synthesis instruments the sam i. as time progressed biosearch was also able to bring other dna synthesizers to market such as the biosearch 8700 biosearch 8800 prep and the cyclone . mergers and acquisitions edit in 1987 biosearch was acquired by new brunswick scientific 7 who later sold the biosearch unit to millipore corporation in 1988 . 8 by 1989 biosearch was renamed milligen biosearch . due to the loss of several corporate officers milligen biosearch was subsequently acquired by perseptive biosystems which in turn was acquired by applied biosystems who eventually retired the biosearch name and products . after taking a short hiatus dr. cook decided to return to the oligonucleotide industry and founded what is currently known as biosearch technologies inc. 9 in 2013 biosearch acquired the oligonucleotide manufacturing arm of dna technology and the entirety of vitrabio a maker of porous glass . 1 recognition in pcr research edit when kary mullis received the nobel prize in 1993 and gave his nobel lecture concerning his invention of the polymerase chain reaction pcr method he gratefully acknowledged biosearch and dr. cook s role in providing him one of the first sam i dna synthesizers which was used in support of kary mullis pcr research . 10 references edit a b biosearch eyes european growth with two acquisitions genetic engineering & biotechnology news paper ed . 33 6 p. 8 march 15 2013 staff may 15 2015 . lgc acquires biosearch technologies . industry watch . genetic engineering & biotechnology news . 35 5 . p. 10 . glen research black hole quencher webpage sigma aldrich black hole quencher webpage http www.umdnj.edu cgi bin cgiwrap hpappweb newsroom.cgi headline foundation venture capital group a foundation of umdnj affiliate sells interest in longevica pharmaceuticals genetic engineering news realtimedesign new brunswick scientific s company history on answers.com millipore corporation s company history on answers.com the biosearch story on biosearchtech.com kary b. mullis nobel lecture december 8 1993 kary b. mullis nobel lecture december 8 1993 millipore corporation s company history on answers.com new brunswick scientific s company history on answers.com the biosearch story on biosearchtech.com sigma aldrich black hole quencher webpage glen research black hole quencher webpage genetic engineering news pcr applications continue to expand october 1 2006 external links edit biosearch technologies website realtimedesign online design service for qpcr and snp genotyping assays patents assigned to biosearch technologies by the united states patent and trademark office ontario cancer institute s use of biosearch technologies products university of texas medical branch s use of probes labeled with black hole quencher retrieved from https en.wikipedia.org w index.php title biosearch technologies & oldid 725266954 categories biotechnology companies of the united statesresearch support companiesnovato californiapetaluma californiatechnology companies based in the san francisco bay areahidden categories pages using infobox company with unsupported parameters navigation menu personal tools not logged intalkcontributionscreate accountlog in namespaces article talk variants views read edit view history more search navigation main pagecontentsfeatured contentcurrent eventsrandom articledonate to wikipediawikipedia store interaction helpabout wikipediacommunity portalrecent changescontact page tools what links hererelated changesupload filespecial pagespermanent linkpage informationwikidata itemcite this page print export create a bookdownload as pdfprintable version languages add links this page was last modified on 14 june 2016 at 16 09 . text is available 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