as nasdaq apri industry biopharmaceutical founded 1987 headquarters san diego california united states key people richard pascoe ceo brian dorsey isvp & chief development officer barbara troupin md mba svp & chief medical officer products vitaros fispemifene rayva femprox revenue us 7.4 million first nine months 2014 number of employees 120 2012 website 1 apricus biosciences inc. is a san diego based biopharmaceutical company advancing innovative medicines in urology and rheumatology . apricus biosciences first product vitaros has been approved in europe and canada for the treatment of erectile dysfunction 1 other compounds in development include low testosterone rheumatology sexual dysfunction pain 2 contents 1 history 2 location 3 products 4 nexact technology 5 leadership 6 references history edit until september 10 2010 when it formally changed its name apricus biosciences inc. nasdaq apri had been operating in the pharmaceutical industry since 1995 under the name nexmed inc. nasdaq nexm . on november 15 2010 apricus bio received canadian approval for its topical ed treatment vitaros and it announced european approval on june 10 2013 . 3 location edit apricus biosciences is headquartered in san diego ca . the company and its subsidiaries has approximately 35 employees . products edit vitaros is a rapid onset generally 5 15 minutes topical cream for the treatment of erectile dysfunction . it contains prostaglandin e1 as the active ingredient and the company s proprietary permeation enhancer nexact which facilitates the delivery of the drug into the blood stream . the current formulation of vitaros requires refrigeration and is delivered via a small individual dispenser . vitaros has been approved for patient use in canada and europe and to date january 24 2015 has been launched by marketing partners in the united kingdom takeda germany sandoz sweden sandoz and belgium sandoz . six additional european territories are expected to launch vitaros during 2015 . apricus has developed a room temperature formulation of vitaros which is housed and delivered in a small custom developed disposable dispenser or room temperature device rtd . initial production of vitaros rtd has commenced in order to generate the required stability data required for marketing approval . the company continues to expect its commercial partners to launch the vitaros rtd in 2016 . 4 in november 2007 apricus biosciences sold the rights for the refrigerated formulation of vitaros in the us to warner chilcott . 5 fispemifene is a new chemical entity initially being pursued for the treatment of low testosterone secondary hypogonadism in males . apricus plans to begin a phase 2b clinical trial with fispemifene in this indication in the first half of 2015 with top line data expected to be reported by the end of 2015 . apricus in licensed the u.s. rights to fispemifene from forendo pharma in q4 2014 . since then it has transferred the regulatory filings from forendo developed a phase 2b clinical trial protocol held a scientific advisory board meeting with experts in the field to refine its development strategy initiated the manufacturing process for the drug and begun the clinical trial site selection process . rayva is a topical cream for the treatment of raynaud s phenomenon a circulatory disorder affecting the hands and feet . patient enrollment commenced in december 2014 for a 45 patient phase 2a clinical trial for rayva which is expected to be completed and results announced in the second quarter in 2015 . rayva has the potential to be the only fda approved treatment for this debilitating condition . rayva contains prostaglandin e1 as the active ingredient and apricus permeation enhancer nexact which facilitates the delivery of the drug into the blood stream . femprox is a topical cream for the treatment of female sexual interest arousal disorder . it contains prostaglandin e1 as the active ingredient and a permeation enhancer nexact which facilitates the delivery of the drug into the blood stream . 2 6 nexact technology edit nexact is a proprietary water soluble small molecule permeation enhancer which temporarily changes the permeation dynamics of the lipid bi layer and transiently loosens the tight junctions between the cells so that active drug molecules can be rapidly absorbed into systemic circulation . the nexact technology is used in both vitaros and rayva . it can also improve the solubility of compounds resulting in enhanced drug permeation . 7 leadership edit richard pascoe ceo mr. pascoe joined apricus in march 2013 following the merger of somaxon pharmaceuticals with pernix . at somaxon mr. pascoe was the chief executive officer since august 2008 and was responsible for the fda approval of somaxon s lead drug silenor . prior to somaxon mr. pascoe was with ariad pharmaceuticals inc. a specialty pharmaceutical company where he was most recently senior vice president and chief operating officer . prior to joining ariad in 2005 mr. pascoe held a series of senior management roles at king pharmaceuticals inc. a specialty pharmaceutical company including senior vice president positions in both marketing and sales as well as vice president positions in both international sales and marketing and hospital sales . prior to king mr. pascoe was in the commercial groups at medco research inc. which was acquired by king cor therapeutics inc. b. braun interventional and the boc group . mr. pascoe is a member of the board of directors of kempharm inc. cohera medical inc. and the corporate directors forum cdf . mr. pascoe served as a commissioned officer with the u.s. army 24th infantry division following his graduation from the united states military academy at west point where he received a b.s degree in leadership . brian dorsey svp chief development officer mr. dorsey has served in the pharmaceutical and biotechnology industries for over 20 years where he has provided high level drug development regulatory and qc qa leadership of pharmaceutical candidates from early development to fda approval . he has held various senior management roles with pharmaceutical companies most recently at pernix therapeutics as senior vice president pharmaceutical development . prior to this mr. dorsey held managerial positions of increasing responsibility at somaxon pharmaceuticals baxter bioscience and pfizer global research and development . mr. dorsey received his master of science in executive leadership and his b.a. in chemistry from the university of san diego . 8 barbara troupin md mba svp chief medical officer dr. troupin has held various senior management roles with vivus inc. in the areas of medical affairs and clinical development since 2006 . in these roles dr. troupin was the clinician lead for the phase 3 program for qsymia as well as the lead contributor for all medical review of the qsymia new drug application and was the lead medical presenter at the successful qsymia fda advisory committee meeting . prior to this dr. troupin held medical director positions at the profil institute for clinical research and radiant research both contract research organizations . dr. troupin received her m.d. from the university of pennsylvania school of medicine and her m.b.a. from the wharton school of business . 9 references edit bujdos brian . new topical erectile dysfunction drug vitaros approved in canada ; approved topical drug testim proves helpful for erectile dysfunction . archived from the original on 13 may 2011 . retrieved 7 april 2011 . a b apricus sec report . sec . retrieved 6 april 2011 . release press june 10 2013 . apricus biosciences receives european approval for vitaros r for the treatment of erectile dysfunction . apricus biosciences globenews . retrieved 24 january 2015 . release press 2014 12 22 . apricus biosciences announces year end 2014 update and 2015 plans to advance its clinical pipeline and further commercialize its erectile dysfunction drug vitaros r . apricus biosciences globenewswire . globenewswire . retrieved 24 january 2015 . form 10 q disclosure . www.sec.gov . sec . retrieved 24 january 2015 . apricus biosciences inc announces patent grant for femprox in japan . reuters . 3 october 2010 . retrieved 7 april 2011 . nexact trasdermal drug delivery technology . nexact trasdermal drug delivery technology . retrieved 6 april 2011 . release press . apricus biosciences appoints brian t. dorsey as chief development officer . www.apricusbio.com . retrieved 24 january 2015 . release press . apricus biosciences appoints barbara troupin m.d. as chief medical officer . www.apricusbio.com . apricus biosciences . retrieved 24 january 2015 . retrieved from https en.wikipedia.org w index.php title apricus biosciences & oldid 744100334 categories pharmaceutical companies of the united statesbiotechnology companies of the united statescompanies established in 1987 navigation menu personal tools not logged intalkcontributionscreate accountlog in 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