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having spent most of his life medicated electroshocked and institutionalized jerome coe finds himself homeless on the coldest night of the century and so with nowhere else to go he accepts a ride out of new england from an old loves ex girlfriend . it doesnt quite work out but he makes it to new orleans and a new life work friends and only the occasional psychotic break . what follows involves his last two chances to find real happiness ones from ecuador one sells cigarettes the old vicious enemies that may prevent him from obtaining it and a cast of crescent city denizens that makes for one of the most vivid ensembles since tooles a confederacy of dunces .