ceiling lights & chandeliers
current progress in the understanding of secondary brain damage from trauma and ischemia proceedings of the 6th international symposium mechanisms o
information is provided from the basic and clinical sciences on the mechanisms damaging the brain from trauma or ischemia . new aspects involve the endoplasmic reticulum mitochondrial failure pathobiology of axonal injury molecular signals activating glial elements or the emerging therapeutical role of neurotrophins . experimental issues involve a better analysis of the ischemic penumbra the salvagable tissue . therapeutic contributions reach from the environmental influence to gene expression including neuroprotection such as hibernation mother natures experiment or hypothermia which is reported to induce cell swelling . treatment issues deal also with thrombolysis and combination therapies or with the clearance of adverse blood components ldl fibrinogen by a novel procedure using heparin . other highlights are discussing the specificities of pediatric vs. adult brain trauma or the evolving role of the apolipoprotein e e4 gene in severe head injury . an update is also provided on an online assessment of the patient management during the pre and early hospital phase in southern bavaria . the empirical observation of neuroworsening is analyzed in further details whether this is a specificity autonomously driving the posttraumatic course . finally the unsolved question why drug trials in severe head injury have failed so far in view of the promising evidence from the laboratory is subjected to an expert analysis .