impact wrenches
lung cancer metastasis novel biological mechanisms and impact on clinical practice
p lung cancer is the leading cause of cancer related mortality . metastatic lung cancer is responsible for more than ninety percent of lung cancer related deaths . however relatively little progress has been made in understanding the process of lung cancer metastasis . the two main aims of this book are a to introduce clinical aspects to basic scientists and basic molecular and cellular concepts to clinical investigators in order to promote collaboration and foster much needed translational research ; and b to introduce new and emerging concepts and approaches in metastasis research to lung cancer research community at large . p in this attempt the book will cover a broad spectrum of subjects ranging from the current trends in the clinical management of the metastatic disease to the systems biology approach for gaining insights into the mechanisms of metastasis . some of the subjects covered will include ; defining basic hallmarks of a metastatic cell the concept of tumor stem cells epithelial mesenchymal transitions evasion of immune surveillance tumor stromal interactions angiogenesis molecular imaging and biomarker discovery .