clamps
dynamic clamp from principles to applications
p dynamic clamp is a fascinating electrophysiology technique that consists of merging living neurons with computational models . the dynamic clamp also called conductance injection allows experimentalists and theoreticians to challenge neurons or any other type of cell with complex conductance stimuli generated by a computer . p the technique can be implemented from neural simulation environments and a variety of custom made or commercial systems . the real time interaction between the computer and cell also enables the design of recording paradigms with unprecedented accuracy via a computational model of the electrode . dynamic clamp from principles to applications contains contributions from leading researchers in the field who investigate these paradigms at the cellular or network level in vivo and in vitro and in different brain regions and cardiac cells . topics discussed include the addition of artificially generated synaptic activity to neurons ; adding amplifying or neutralizing voltage dependent conductances ; creating hybrid networks with real and artificial cells ; attaching simulated dendritic tree structures to the living cell ; and connecting different neurons . p this book will be of interest to experimental biophysicists neurophysiologists and cardiac physiologists as well as theoreticians engineers and computational neuroscientists . graduate and undergraduate students will also find up to date coverage of physiological problems and how they are investigated . p about the editors p dr. alain destexhe and dr.thierry bal are research directors at the centre national de la recherche scientifique cnrs a governmental research institution in france . their laboratories are located in the cnrs campus of gif sur yvette in the research unit unite de neurosciences integratives et computationnelles unic . gif sur yvette is solely devoted to research and provides an ideal environment for close interaction between theory and experiments as exemplified by the numerous publications on dynamic clamp experiments co authored by dr. bal and dr. destexhe . each editor holds ph.d. s in biophysics and neurobiology respectively . dr. destexhe is also chief editor of the journal of computational neuroscience .