EDUCATION:

September 1997 - May 1999

• Graduate student in the Department of Computer Sciences at the University of Wisconsin - Madison and obtained Master's Degree in Computer Science.

January 1990 - May 1994

• Graduate student in the University of Paris XII, Créteil, France and obtained Ph.D in Cell Biology and Molecular Toxicology.

September 1986 - June 1989

• Graduate student in Nanjing Medical College, China and obtained Master's Degree in Toxicology and Pharmacology.

March 1978 - December 1982

• Medical school student in Nanjing Medical College, China and obtained Bachelor's Degree in Medicine.

PROFESSIONAL ACTIVITIES:

In Computer Sciences:

December 2002 - Present

• Informatics/IS Application Specialist at Aventis Pharmaceuticals Inc. . Tucson, AZ.
  - ActivityBase administrator, responsible for protocols/templates design and implementation for lead discovery data management in both HTS and LTS databases.
  - Close collaboration with chemists and lead discovery biologists to identify key requirements for automated data capture, quality control, result analysis and sharing data globally across projects.
  - Daily problem solving, user training and documentations.

  August 2000 - August 2002

• Informatics Research Scientist in the department of Informatics at Exelixis Inc . South San Francisco, CA.
  - Large cheminformatics database (IDBS ActivityBase) administrator, responsible for database setup, maintenance, trouble-shooting and customization.
  - Assay protocol design and implementation for efficient scientific data management, including automatic data import into the database, quality control, appropriate data analysis and result interpretation. Have designed UHTS, HTS and other standard protocols for High Throughput Screening, Dose-response IC50/EC50 measurements(including curve fitting), In vitro ADMET, In vivo PK/ADME and Efficacy assays.
  - Close collaboration with chemists and new leads biologists for software customization and new tool development by adding Excel Macros and the other web based applications.
  - Structure-Activity report generation, data mining and visualization using SARgen, Spotfire and other in-house software applications.
  - Web based application development for data analysis and retrieval with Python, SQL, Java, JavaScript, allowing users to get info from databases on the web.
  - Internal informatics user training and daily problem solving for scientific or technical issues. Identify, evaluate, deploy and test new software, databases and other informatics tools for new needs.

  August 1999 - August 2000

• Software Engineer in the department of Web Information Technology, a subdivision of IBM AIX RS/6000 Server Group, Austin, TX.
  - Oracle database administrator and server application developer using Oracle PL/SQL Web Toolkit. Web based reporting system development for users to get info from databases on the web.
  - AIX program product packaging.

January 1999 - July 1999

• Software Engineer at DNASTAR Inc . Madison, WI.
  - Sequence analysis software development (LaserGene, SeqMan II) for genetic research on Windows and Apple Macintosh platforms using C programming language.

June 1998 - August 1998

• Summer Intern as a Software Engineer (QA) with Greystone Group at Sanchez Computer Associates, Inc. Malvern, PA.
  - Established test suites using MUMPS programming language and Shell scripts for testing different features of GT.M database system (a Greystone Technology Corporation's implementation of standard MUMPS for UNIX and VAX/VMS systems) in UNIX and VMS platforms.
  
  

Computer Technical Skills:

• Programming Languages: C/C++, Java, Python, VB/VBA, MUMPS, SQL, QBE, UNIX Shell (C Shell and KornShell), PERL, HTML, XML, JavaScript.
  
  
• Platforms: SUN/AIX/HP UNIX Workstations, X Window, VAX/VMS, LINUX, Windows 95/98/NT and Macintosh Programming
  
  
• Bioinformatics Tools: BLAST, sequence alignment, contig assembly, primer design,LIMS, Phred, Phrap, HMM, DANStar SegMan II, LaserGene
  
  
• Cheminformatics Tools: MDL ISIS database, ActivityBase, Scitegic Pipeline Pilot, Spotfire, XLFit

Programming Projects:

• Database Projects:

  • Implemented Buffer Manager (manages buffer pool), Heap File Manager, B+ Trees, Sort Merge Join on a DBMS in C++.
  • Designed and implemented Disk Space Manager (allocation and deallocation of pages within a database), Buffer Manager, Heap File Manager in Java.
  
  

• Operating System Projects:

  • Developed protocols for interprocess communication and synchronization using pipes, semaphores in C++.
  • Simulated and evaluated different page replacement algorithms using real memory trace data from UNIX systems in C++.
  • Measured kernel performance using extended lmbenchmark in C.
  • Developed a prefetching protocol for Web access streams by using aged probability graphs in C.
  • Designed a parallel workload generator, an analyzer and a CPU scheduler for a parallel computer with a graphic user interface in Java.
  
  

• Networking Projects:

  • Developed a Client-Server protocol with UDP as its transport layer protocol using BSD Socket and Posix thread in C.
  • Built a reliable transport layer protocol over a virtual-circuit (VC) based network layer protocol in C++. File Transfer Application (FTP) was linked to protocols which supported reliable file transfers between nodes across an unreliable network.

In Biological Research:

November 1994 - January 1999

• Assistant Researcher, Lab Manager in the Department of Human Oncology, Comprehensive Cancer Center, UWCCC, University of Wisconsin at Madison
  Clinical research lab manager. Research projects: "Regulation of tumor cell kinetics using in vitro and in vivo models".
  Responsible for experiment design, supervising, assay data analysis using different bioinformatics software and scientific paper publication.

January 1990 - May 1994

• Research assistant in the Laboratory of Environmental Cellular and Molecular Toxicology, INSERM U.139, CHU Henri Mondor, Créteil 94010, France.
  Ph.D thesis study on mechanisms of cytotoxicity and DNA damage induced by asbestos and other chemicals using in vivo and in vitro models.

PUBLICATIONS:

Dong HY, Saint-Etienne L, Renier A, Billon-Galland MA, Brochard P and Jaurand MC. Air samples from a building with asbestos containing material: Asbestos content and in vitro toxicity on rat pleural mesothelial cells. Fundamental and Applied Toxicology, 22:178-185, 1994.

Dong HY, Buard A, Renier A, Saint-Etienne L and Jaurand MC. Role of oxygen derivatives in the cytotoxicity and DNA damage produced by asbestos on rat pleural mesothelial cells in vitro. Carcinogenesis, 15:1251-1255, 1994.

Dong HY, Yegles M, Renier A, Bignon J and Jaurand MC. Cytotoxic and genotoxic effects of vitreous microbeads with different iron content on rat pleural mesothelial cells in culture. ILSI (International Life Sciences Institute) Series, Eds by Mohr,U.; Dungworth,D.L.; Oberdorester,G. In: Toxic and carcinogenic effects of solid particles in the respiratory tract. ILSI Press, Washington D.C., p.419-422, 1994.

Dong HY, Buard A, Levy F, Renier A, Laval F and Jaurand MC. Synthesis of poly(ADP-ribose) in asbestos-treated rat pleural mesothelial cells in culture. Mutation Research, 331:197-204, 1995.

Yegles M, Janson X, Dong HY, Renier A, and Jaurand MC. Role of fibre characteristics on cytotoxicity and induction of anaphase/telophase aberrations in rat pleural mesothelial cells in vitro - Correlations with in vivo animal findings. Carcinogenesis, 16:1251-2758, 1995.

Dong HY, Bertler C, Schneider E and Ritter MA. Assessment of cell proliferation by AgNOR scores and Ki-67 labeling indices and a comparison with potential doubling times. Cytometry, 28:280-288, 1997.

REFERENCES:

Available upon request.