Uses of Protein Motion

Van Wynsberghe, Adam W., and Qiang Cui. Interpreting Correlated Motions Using Normal Mode Analysis

• Identify flexible and rigid motifs in large biomolecules, which may suggest sites for mutation or other experiments.
• Refine structural data
• Search for ligand binding sites

Ma, Jianpeng. Usefulness and Limitations of Normal Mode Analysis in Modeling Dynamics of Biomolecular Complexes

• Structural refinement against x-ray diffraction data, electron cryomicroscopy and fiber diffraction