Population genomic inference using patterns of polymorphism at SNPs and microsatellites in humans

Rationale and approach

Testing models of natural selection at linked sites in humans

Scanning the human genome for recent selective sweeps

Investigating expected correlations between diversities at SNPs and microsatellites

Measurement of linkage disequilibrium between SNPs and microsatellites across the human genome

Publications

Payseur, B. A., and A. D. Cutter (2006). Integrating patterns of polymorphism at SNPs and STRs. Trends in Genetics 22:424-429.

Storz, J. F., B. A. Payseur, and M. W. Nachman (2004). Genome scans of DNA variability in humans reveal evidence of selective sweeps outside of Africa. Molecular Biology and Evolution 21:1800-1811.

Payseur, B. A., and M. W. Nachman (2002). Natural selection at linked sites in humans. Gene 300:31-42.

Payseur, B. A., A. D. Cutter, and M. W. Nachman (2002). Searching for evidence of positive selection in the human genome using patterns of microsatellite variability. Molecular Biology and Evolution 19:1143-1153.

Payseur, B. A., and M. W. Nachman (2002). Gene density and human nucleotide polymorphism. Molecular Biology and Evolution 19:336-340.

Payseur, B. A., and M. W. Nachman (2000). Microsatellite variation and recombination rate in the human genome. Genetics 156:1285-1298.

Genetic basis of speciation in house mice (Michael White)

Rationale and approach

Surveys of introgression in natural hybrid zones

Genomic scans for epistatic selection against hybrid gene combinations in inbred mouse strains

QTL mapping of hybrid male sterility

Publications

Payseur, B. A., and M. Place (2007). Searching the genomes of inbred mouse strains for incompatibilities that separate their wild relatives. Journal of Heredity.

Payseur, B. A., and H. E. Hoekstra (2005). Signatures of reproductive isolation in patterns of single nucleotide diversity across inbred strains of house mice. Genetics 171:1905-1916.

Payseur, B. A., and M. W. Nachman (2005). The genomics of speciation: investigating the molecular correlates of X chromosome introgression across the hybrid zone between Mus domesticus and Mus musculus. Biological Journal of the Linnean Society 84:523-534.

Payseur, B. A., J. G. Krenz, and M. W. Nachman (2004). Differential patterns of introgression across the X chromosome in a hybrid zone between two species of house mice. Evolution 58:2064-2078.

Genetic architecture of complex trait variation

Rationale and approach

Development of methods for associating genotype and phenotype

Evaluation of association mapping in classical strains of mice

QTL mapping of morphological variation using inbred mouse strains

Evolution of large body size in island mice

Publications

Payseur, B. A., and M. Place (2007). Prospects for association mapping in classical inbred strains of mice. Genetics 175:1999–2008.

Payseur, B. A., A. G. Clark, J. Hixson, E. Boerwinkle, and C. F. Sing (2006). Contrasting multi-site genotypic distributions among discordant quantitative phenotypes: the APOA1/C3/A4/A5 gene cluster and cardiovascular disease risk factors. Genetic Epidemiology 30:508-518.

Evolution of recombination rate in mammals (Beth Dumont)

Rationale and approach

Evaluating evidence of selection on recombination hotspot motifs

Modeling evolutionary divergence in recombination rate in a phylogenetic context

Publications

Jensen-Seaman, M. I., T. S. Furey, B. A. Payseur, Y. Lu, K. M. Roskin, C.-F. Chen, M. A. Thomas, D. Haussler, and H. J. Jacob (2004). Comparative recombination rates in the rat, mouse, and human genomes. Genome Research 14:528-538.