A fast-paced, spirited gay farce, He's My Girl follows the adventures of Simon Eskenazy (Antoine de Caunes). A successful musician in the process of finishing an album, Simon is a very busy man. Already overextended by work, he hits a breaking point when his melodramatic, ailing mother (Judith Magre) insists that he care for her in a time of need. If all that weren't bad enough, he's also juggling an insistent agent, an ex-wife, a ten-year-old son and two younger male lovers. With a fit body and professorial good looks, Simon doesn't have trouble finding young guys with "daddy" fantasies to satisfy his horndog impulses. He has been in a relationship with Raphael (Micha Lescot) for more than a year, but soon finds his interest divided when he meets Naim (Medhi Debhi), a talented female impersonator who turns him on both in and out of drag. Simon is feeling the pangs of true love, but is reluctant to admit it. However, when Naim, in character as "Rose," proves adept at caring for his high-maintenance, bed-ridden mother, he starts reconsidering all of his preconceived notions and fears.