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This unique new reference contains the Carcinogenic Potency Database (CPDB), which analyzes results of decades of animal cancer tests, including all Technical Reports of the National Toxicology Program (NTP) and the general published literature. A guide to the literature of animal cancer tests, the CPDB includes references to each published experiment and never-before published analyses.
For each of 5,000 long-term experiments on 1,300 chemicals, the user-friendly format includes data on the species, strain, and sex of the test animal; features of experimental protocol such as the route of administration, duration of dosing, dose levels, and duration of the experiment; histopathology and tumor incidence; the shape of the dose-response curve; published author's opinion about the carcinogenicity at each site; and reference to the original publication of the test results. In addition, a measure of carcinogenic potency, the TD50, its statistical significance and confidence limits, are given for each tumor site. An overview is provided of earlier publication updates, such as positivity rates, reproducibility, interspecies extrapolation, and ranking possible carcinogenic hazards.
The book also includes a summary of the NTP genetic toxicity test results on 1,500 chemicals, which are referenced to the original publications, including the Salmonella (Ames) test, L5178Y mouse lymphoma cell mutation test, chromosome aberration and sister chromatid exchange tests in cultured Chinese hamster ovary cells, and the sex-linked recessive lethal mutation test in Drosophila melanogaster.
An index with chemicals listed by CAS number allows cross referencing between the carcinogenicity and genotoxicity databases, making data easy to find.
The book contains black-and-white illustrations.
Carcinogenic Potency Database, L. Swirsky Gold, T.H. Slone, N.B. Manley, G. Backman Garfinkel, L. Rohrbach, and B.N. Ames Methods for the Carcinogenic Potency Database Guide to the Plot of the Carcinogenic Potency Database Plot of Cancer Test Results Appendices of Codes and Definitions Carcinogenicity Bibliography Carcinogenicity Bibliography - NCI/NTP Technical Reports Carcinogenicity Bibliography - General Literature Summary of Carcinogenic Potency Database by Target Organ, L. Swirsky Gold, N.B. Manley, and T.H. Slone Summary of Carcinogenic Potency Database by Chemical, L. Swirsky Gold, T.H. Slone, and B.N. Ames Summary of Chemical Carcinogenicity in Rats and Mice Summary of Chemical Carcinogenicity in Hamsters Summary of Chemical Carcinogenicity in Nonhuman Primates and Dogs Overview and Update of Analyses of the Carcinogenic Potency Database, L. Swirsky Gold, T.H. Slone, and B.N. Ames Genotoxicity Database, E. Zeiger Description of Genotoxicity Tests Table of Genotoxicity Results Genotoxicity Bibliography Index of Chemical Names in the Carcinogenic Potency (CPDB) and Genotoxicity (GT) Databases by Chemical Abstract Service (CAS) Registry Number
Overview
This unique new reference contains the Carcinogenic Potency Database (CPDB), which analyzes results of decades of animal cancer tests, including all Technical Reports of the National Toxicology Program (NTP) and the general published literature. A guide to the literature of animal cancer tests, the CPDB includes references to each published experiment and never-before published analyses.
For each of 5,000 long-term experiments on 1,300 chemicals, the user-friendly format ...