Multimodality Therapy for Gastric Cancer: Appendix: Database of the Cancer Institute Hospital / Edition 1

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Overview

Recent clinical trials of adjuvant therapy for gastric cancer in Japan have shown improved survival benefits, but the results have been considered controversial and have been viewed with some skepticism in the West. Until now, the efforts of Japanese surgical oncologists in multimodality therapy have not been fully understood because they have not been adequately reported in English. This volume now presents the experience and expertise of Japanese surgeons who utilize preoperative or intraoperative chemotherapy, or a combination of systemic and regional chemotherapy. Their collected work provides valuable insight in the Japanese perspective and success in treating gastric cancer. Included in the appendix is an extensive tabular analysis of the gastric cancer database at the Cancer Institute Hospital of Tokyo. Probably the largest such database in the world from a single institution, the analyses present the state of the art in treatment of gastric cancer.

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Jonas Maguusson, MD, PhD (Landspitalinn University Hospital)
Description: This is a comprehensive overview of multimodal therapy for gastric cancer as practiced by Japanese surgeons. It is multi-authored (mainly Japanese) and both review chapters and original work are included. Not least, an appendix of the tabular analysis of the gastric cancer database of the Cancer Institute in Tokyo with over 12000 patients (probably the largest in the world) is included.
Purpose: The survival rates after gastric cancer surgery are poor in the West compared to Japan. The purpose of this book is to present the Japanese methods which have given much better results and to highlight the need for randomized studies. The studies presented here give the reader ideas to initiate novel treatment methods. This work will contribute to the development of future clinical research. The editors have certainly succeeded in their goals in this much-needed book.
Audience: The intended audience includes surgical oncologists, general surgeons, and medical oncologists. Fellows and residents in these fields will find it useful.
Features: The book is divided into six sections and an appendix. In the first section adjuvant chemotherapy is covered. The Japanese experience is reviewed in a very well written chapter. The non-Japanese experience and meta analysis of adjuvant chemotherapy is reviewed. In the second section prevention and control of peritoneal dissemination is discussed, including peritonectomy, a procedure not performed in the West. In the third section liver metastasis is covered, and in the fourth control of distant lymph node metastases is presented. The fifth section deals with neoadjuvant chemotherapy for operable diseases. There is considerable interest in this field currently with ongoing studies. In the last section future perspectives in various directions are discussed. Each chapter is up to date and adequate references are provided. The appendix contains the tabular analysis of Cancer Institute Hospital Database on gastric cancer. The tables are detailed and this appendix is invaluable for gastric cancer research. Indeed, it sets the standard for the Western world.
Assessment: This is an excellent and unique book on gastric cancer. The Japanese experience and thoughts on gastric cancer are detailed. Physicians caring for gastric cancer patients should read this book.
Jonas Maguusson
This is a comprehensive overview of multimodal therapy for gastric cancer as practiced by Japanese surgeons. It is multi-authored (mainly Japanese) and both review chapters and original work are included. Not least, an appendix of the tabular analysis of the gastric cancer database of the Cancer Institute in Tokyo with over 12000 patients (probably the largest in the world) is included. The survival rates after gastric cancer surgery are poor in the West compared to Japan. The purpose of this book is to present the Japanese methods which have given much better results and to highlight the need for randomized studies. The studies presented here give the reader ideas to initiate novel treatment methods. This work will contribute to the development of future clinical research. The editors have certainly succeeded in their goals in this much-needed book. The intended audience includes surgical oncologists, general surgeons, and medical oncologists. Fellows and residents in these fields will find it useful. The book is divided into six sections and an appendix. In the first section adjuvant chemotherapy is covered. The Japanese experience is reviewed in a very well written chapter. The non-Japanese experience and meta analysis of adjuvant chemotherapy is reviewed. In the second section prevention and control of peritoneal dissemination is discussed, including peritonectomy, a procedure not performed in the West. In the third section liver metastasis is covered, and in the fourth control of distant lymph node metastases is presented. The fifth section deals with neoadjuvant chemotherapy for operable diseases. There is considerable interest in this field currently with ongoingstudies. In the last section future perspectives in various directions are discussed. Each chapter is up to date and adequate references are provided. The appendix contains the tabular analysis of Cancer Institute Hospital Database on gastric cancer. The tables are detailed and this appendix is invaluable for gastric cancer research. Indeed, it sets the standard for the Western world. This is an excellent and unique book on gastric cancer. The Japanese experience and thoughts on gastric cancer are detailed. Physicians caring for gastric cancer patients should read this book.

3 Stars from Doody
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Product Details

  • ISBN-13: 9784431702559
  • Publisher: Springer Japan
  • Publication date: 8/13/1999
  • Edition description: 1999
  • Edition number: 1
  • Pages: 272

Table of Contents

Dedication
Preface
Color Plates
Adjuvant Chemotherapy for Gastric Cancer
Success of Adjuvant Chemotherapy Trials for Gastric Cancer 3
Randomized Controlled Trials on Adjuvant Therapy for Gastric Cancer: Japanese Experience 7
Multimodality Therapy for Completely Resected (R0) Gastric Cancer (Excluding Japanese Trials) 17
Meta-Analysis of Adjuvant Chemotherapy Trials for Gastric Cancer at the Cancer Institute Hospital, Tokyo 27
Adjuvant Chemotherapy of Gastric Cancer: JCOG Experience 32
Prevention and Control of Peritoneal Dissemination
Activated Carbon Particles Adsorbing Mitomycin C Used Against Peritoneal Carcinomatosis in Gastric Cancer 45
Control of Peritoneal Dissemination with Sequential Methotrexate and 5-Fluorouracil 51
Intraperitoneal Chemotherapy with Mitomycin C or Cisplatin 58
Usefulness of Intraperitoneal Administration of Cisplatin Using a Reservoir for Advanced Gastric Cancer Complicated by Peritoneal Dissemination 66
Peritonectomy as a Treatment Modality for Patients with Peritoneal Dissemination from Gastric Cancer 71
Control of Liver Metastasis
Management of Liver Metastases 83
Control of Liver Metastasis by Intrahepatic Chemotherapy with Angiotensin II 90
Control of Distant Lymph Node Metastasis
Neoadjuvant Chemotherapy with FLEP Regimen for Incurable Gastric Cancer 97
Case Report of Pathological Complete Remission with FLEP Therapy 104
Neoadjuvant Chemotherapy with FLEP Therapy for Advanced Gastric Cancer: Evaluation of Intraaortic and Intravenous FLEP Infusions 108
Neoadjuvant Chemotherapy for Operable Disease
Rationale for Neoadjuvant Chemotherapy for Advanced Gastric Cancer 115
Multimodality Therapy of Locoregional Gastric Carcinoma 122
Histopathological Effect of Preoperative Chemotherapy Using Oral 5-Fluorouracil in Patients with Operable Gastric Cancer 126
Neoadjuvant Chemotherapy of Gastric Cancer with UFT 131
Neoadjuvant Systemic Chemotherapy for Advanced Gastric Cancer with Noncurative Clinical Factors 141
New Strategy for the Treatment of Advanced or Recurrent Gastric Carcinoma: Neoadjuvant Immunochemotherapy of FLPO Regimen (5-FU, Leucovorin, CDDP, OK-432) 148
Intraoperative Local Infusion Chemotherapy for Advanced Gastric Cancer 154
The Future Perspective
Future Clinical Trial of Adjuvant Chemotherapy with Sensitivity Test 163
Angiogenesis and Angiogenic Factors of Gastric Cancer 170
Intratumoral Angiogenesis and Micrometastasis in Bone Marrow of Patients with Gastric Cancer 177
Targeting Chemotherapy of Peritoneally Disseminated Gastric Cancer with Monoclonal Antibody-Drug Conjugates 183
Future Perspectives of Gene Therapy for Gastric Cancer 187
Appendix 195
Subject Index 269
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