These are notes built around a text in preparation titled
``Statistical Methods for Quantitative Trait Loci
in Experimental Crosses'' by
KW Broman, GA Churchill, BS Yandell, ZB Zeng.
Numbered chapter/notes are mine; indented subheadings are links to
useful ancillary material. Citations within my notes are to Quantitative Trait Loci References.
- 0 Overview
- 1 General Biology Relevant to QTL
- Central
Dogma of Molecular Biology, Access Excellence
- Central Dogma, MIT Biology Hypertextbook
- Meiosis
Tutorial, Biology Project, U AZ
- The Inner Life of a Cell, Biovisions, Harvard U
- A Biologist's Mother's Day Song
- Nobel e-Museum:
- Meiotic
Cytology, DG Peterson, MS Genome Exploration Lab, MS St U
- Introduction to Recombination and Linkage
Analysis, MS McPeek, Statistics, UC Berkeley
- Review
of statistical methods for QTL mapping in experimental crosses,
KW Broman (2001) Lab Animal 30(7): 44-52.
- 2 Key Statistical Ideas for QTL
- 3 Marker Regression Analysis
- 4 Interval Mapping for Single QTL
- 5 Sample Size, Power & Thresholds
- Experimental
Design and Sample Size Requirement for QTL Mapping, ZB Zeng (2003),
NCSU Bioinformatics, PAG XI
- 6 Model Selection for Multiple QTL
- Assessment
of Model Selection, KW Broman, Johns Hopkins U, & TP Speed, UC Berkeley
- Mapping
and characterizing QTL in inbred line crosses, GA Churchill (2001),
Jackson Laboratory
-
Sillanpaa MJ, Arjas E (2002)
Model choice in gene mapping: what and why.
Trends in Genetics 18: 301-307.
- 7 Multiple QTL Implementation
- Mapping
and characterizing QTL in inbred line crosses, GA Churchill (2001),
Jackson Laboratory
- 8 QTL for Multiple Crosses
- Experimental
Design and Sample Size Requirement for QTL Mapping, ZB Zeng (2003),
NCSU Bioinformatics, PAG XI
- Hardy-Weinberg & Linkage Disequilibrium
(Yandell 2001 notes based on Zeng 2000 book draft)
- Transmission
Disequilbrium Test, Statistical Genetics, UC Berkeley, TP Speed
- Finding
Disease Genes, Human Genetics 500, Yale U, R Lifton
- 9 Multiple Traits and Environments
- Jiang & Zeng (1995) CIM approach
(Yandell 2001 notes based on Zeng 2000 book draft)
- Gene Mapping for High Throughput
Expression Profiles: Lessons from Diabetes (Yandell talk in Genetics
Colloquium, 2000) [1.3M]
- 10 Extensions of the Phenotype Model
- QTL References
Return to Statistical Genomics Course Page.
www.stat.wisc.edu/~yandell/statgen/course/
by Brian Yandell
(yandell@stat.wisc.edu)