# Network connectivity inference over curvature regularizing line graphs

Maxwell D. Collins, Vikas Singh, Andrew L. Alexander, "Network Connectivity inference over curvature regularizing line graphs", Proceedings of Asian Conference on Computer Vision (ACCV), November 2010.

## Abstract

Diffusion Tensor Imaging (DTI) provides estimates of local directional information regarding paths of white matter tracts in the human brain. An important problem in DTI is to infer tract connectivity (and networks) from given image data. We propose a method that infers high-level network structures and connectivity information from Diffusion Tensor images. Our algorithm extends principles from perceptual contours to construct a weighted line-graph based on how well the tensors agree with a set of proposal curves (regularized by length and curvature). The problem of extracting high-level anatomical connectivity is then posed as an optimization problem over this curvature-regularizing graph — which gives subgraphs which comprise a representation of the tracts' network topology. We present experimental results and an open-source implementation of the algorithm.

- Accepted for Oral Presentation
- Winner of
**Best Application Paper**at ACCV 2010 - Funding: NIH R21-AG034315, NIH MH62015, UW ICTR 1UL1RR025011, NLM 5T15LM007359 via CIBM, Morgridge Institute for Discovery.