Fwd from Tuan V Nguyen RE: GM Food va` Tha^`n du+o+.c

["Hoa Nguyen" <thanhhuy@email.msn.com>]

Hi ba'c Hoang,
>Great ! Ne^'u thuo^'c na`y ba'n qua OTC thi` nho+` ba'c mua giu`m mo^.t
thie^n
>dde^? du`ng da^`n. :-)).  A` ma` sao kho^ng tha^'y ba'c na`o kha'c muo^'n
mua
>bupropion va^.y.Tui nho+` ba'c Tua^'n mua ddu+o+.c, sau na`y hu't ha`ng
ba'c
>na`o ca^`n thi` tui "cu+'a" dda^'y. :-))
Tui mo+'i vu+`a nha^.n ddu+o+.c ca'i Current Contents file,
va` trong ddo' co' mo^.t ba`i ba'o tu+.a dde^` la` "Cessation of
nail-biting and bupropion" (Can J Psychiatry 1999; 44:709-10).
Xem ra thuo^'c na`y co`n tri. luo^n ca? ma^'y ca'i chu+'ng nhu+
ca('n mo'ng tay!!!  Tui ho+i nghi vu. na`y.  Ca'c co^ ga'i ddang
ye^u cu~ng co' khi la`m bo^. la`m ti.ch ca('n mo'ng tay, hay va^n
ve^ to'c (la`m bo^. e the.n ma`!) thi` co' tri. ba(`ng bupropion
kho^ng dda^y? :-))
Thu+.c ra, tui no'i tha^.t ba'c a`.  Chuye^.n gi` thi` ddu`a
ddu+o+.c, chu+' thuo^'c men thi` NO.  Tui co' ddo.c the^m va`i ba`i
ba'o ve^` bupropion, thi` qua? la` ngoa`i depression na`y no. ra,
no' tri. nghie^.n thuo^'c la'. Sau dda^y la` va`i papers ve^` vu.
na`y:
Am J Psychiattry 1999; 156:789-9
J Clin Psychiatry 1999; 60:S32-5
J Clin Psychiatry 1999;60:S38-44
NEJM 1999; 341:610-1
Trong mo^.t research o+? Mayo Clinic, ho. thu+? nghie^.m tre^n 615
ngu+o+`i nghie^.n thuo^'c la'.  Ho. chia so^' ngu+o+`i na`y tha`nh
4 nho'm: (A) placebo; (B) bupropion 100 mg/d; (C) 150 mg/d; va`
(D) 300 mg/d. Ho. tri. 7 tua^`n. Sau 7 tua^`n, so^' ngu+o+`i he^'t
nghie^.n thuo^'c la' nho'm A la` 19%, so vo+'i 28% o+? nho'm B,
39% nho'm C va` 44% nho'm D.  Kho^ng co' ai bi. seizures ca?!
Ba'c thu+? cho be^.nh nha^n VN du`ng bupropion xem.  Bie^'t
dda^u co' va`i ddie^`u thu' vi. ddu+o+.c kha'm pha'.

>Ve^` chuye^.n la`m clinical trial thi` tha^.t su+. tui kho^ng ra`nh la('m.
Chi? bie^'t
>mo^.t ca^.u ba.n la`m qua?n ly' khu vu+.c Cha^u A' cu?a Pfizer ve^`
clinical trial
>ba?o ra(`ng co`n ra^'t nhie^`u kho' kha(n dde^? thu+.c hie^.n o+? Vie^.t
Nam
>ne^n du` ra^'t muo^'n (Ca^.u na`y la` Vie^.t kie^`u, tre? va` ra^'t gio?i)
cuo^'i
>cu`ng cu~ng pha?i cho.n Nha^.t dde^? la`m.
Tui dda~ la`m kha' nhie^`u ve^` clinical trials va` ddang
la`m 2 ca'i o+? dda^y, ne^n cu~ng bie^'t so+ qua vu. na`y chu't chu't.
Bo.n co^ng ty thuo^'c kho^ng pha?i la`m clinical trials bu+`a ba~i
dda^u.  Va^'n dde^` la` ho. bo? ra ca? tra(m nga`n ddo^, ho.
muo^'n ca'i results pha?i interpretable thi` ho. mo+'i da'm la`m.
Ma` muo^'n the^' thi` ho. tru+o+'c tie^n pha?i coi xem trung ta^m
muo^'n la`m co' co+ so+? va^.t cha^'t va` resource (eg lab, support
staff, technicians, transportation, logistic ...) dda^`y ddu? kho^ng,
ke^' dde^'n la` ho. coi CV cu?a ba'c si~ hay investigator co' "sound"
kho^ng (vi` ne^'u CV "mo?ng" qua' = thie^'u kinh nghie^.m research,
ho. se~ kho^ng da'm la`m, vi` cha('c la` results se~ cha(?ng published
ddu+o+.c), ro^`i sau ddo' la` ca'c khoa?n nhu+ kinh nghie^.m va` kha?
na(ng recruitment be^.nh nha^n.  Nhie^`u trung ta^m o+? VN mi`nh
thie^'u ma^'y khoa?n na`y.  Nhie^`u khi tui ddo.c va`i ca'i proposals
tu+` VN ma` ra^`u, vi` ddo^`ng nghie^.p be^n a^'y coi thu+o+`ng
nhie^`u chi tie^'t qua'.  Cha(?ng ha.n nhu+ ho. kho^ng no'i recruit
be^.nh nha^n tu+` dda^u, ba(`ng ca'ch na`o, timelines, bao nhie^u,
ta.i sao, serum va` urine samples handled ra la`m sao, o+? dda^u,
ba?o qua?n, shipping, v.v. va` v.v.  kho^ng pha?i chi? tra? lo+`i
chung chung 1, 2 ha`ng chu+~ la` xong dda^u; ho. ddo`i chi tie^'t
cu. the^?.  Clinical trial la` mo^.t cooperation nhie^`u expertise
nhu+ y khoa, biostatisticians, computer scientists, radiographers,
nuclear medicine (tu`y nga`nh), biochemists, nursing, media campaign,
va` tha^.m chi' economists.  Mo^.t mi`nh ba'c kho^ng ta`i na`o la`m
ddu+o+.c.
Tha`nh ra, ca'i secret dde^? thuye^'t phu.c ho. la` ba'c
pha?i draw up mo^.t ca'i study protocol cho tha^.t sound, tu+'c la`
tha^.t thuye^'t phu.c.  Ba'c pha?i vie^'t la`m sao ma` bo.n no'
ddo.c qua la` no'i "They know what they are talking about."  Lu'c
ddo' thi` chi? ca^`n cho music vo^ lo^~ tai bo.n no' la` xong. :-)
Ne^'u ba'c ca^`n co' mo^.t ca'i frame cho ca'i study protocol thi`
tui co' the^? gu+?i cho.  Thu+.c ra, co' i't nha^'t la` ca? chu.c
sa'ch ve^` ca'ch la`m clinical trials.  Nga`nh na`y co`n co' luo^n
mo^.t journal ra^'t uy ti'n nu+~a: Controlled Clinical Trials.

>> >To` mo` mo^.t chu't ve^` y ho.c, kho^ng bie^'t co+ che^' ta'c ddo^.ng
cu?a
>> >thuo^'c na`y the^' na`o. Co' lie^n quan gi` dde^'n endorphine kho^ng ?
>
>> Tui cu~ng cha(?ng bie^'t no' la`m vie^.c ra la`m sao.
>> Ca'i na`y pha?i chuye^n nga`nh mo+'i bie^'t chi'nh xa'c.  Nhu+ng
>> vi` no' du`ng cho depression thi` cha('c cu~ng co' ta'c ddo^.ng
>> to+'i beta lipotropin.
>
>Ca'm o+n ba'c Tua^'n nhie^`u. Cha('c la` sau na`y khi no' ddu+o+.c pho^?
bie^'n
>ho+n se~ co' nhie^`u ta`i lie^.u.
Tui co' ti`m MIMS va` tha^'y ho. ta? la` "The mechanism by which
bupropion sustained releas tablets enhance the ability of patients to
abstain from smoking is unknown.  However, it is presumed that this
action is mediated by both noradrenergic and dopaminergic mechanisms
which may affect the central nervous system's addition pathways."
Well, ho. cu~ng cha? bie^'t luo^n, va` ca'i ddoa.n gia?i thi'ch sau
cu~ng ... hue^` vo^'n. :-))
Ba'c cho tui ho?i la` o+? VN ba^y gio+` ngu+o+`i ta co' cho
HRT kho^ng?  Ddo^'i tu+o+.ng be^.nh nha^n na`o thu+o+`ng du`ng HRT?
O+? VN co' co^ng ty na`o ba'n Alendronate va` SERM (raloxifen) chu+a?

>O+? VN thi` kho^ng tha^'y co' rao ba'n loa.i na`y, co`n tha^.t su+. co'
loa.i na`o
>nha^.p va`o kho^ng thi` chu+a ro~. Kho^ng bie^'t the^' na`o nhu+ng ga^`n
dda^y
>tui tha^'y mo^.t so^' loa.i tra'i ca^y la.. DDie^?n hi`nh ho^m qua tui
mo+'i a(n
>mo^.t tra'i co'c ra^'t to, da`i dde^'n 13cm (3 tra'i khoa?ng 1kg 200).
Ngu+o+.c
>la.i o+? VN hie^.n gio+` ddang co' mo^'t tro^`ng va` a(n "Rau sa.ch" vi`
mo.i
>ngu+o+`i qua' so+. thuo^'c tru+` sa^u.
Tui nghi la` GM food qua' ...  O+? U'c, ho. ddang ba`n ca~i
la` co' ne^n ba('t buo^.c ngu+o+`i sa?n xua^'t pha?i dde^` ro~ la`
"genetically modified food/plant" hay kho^ng.  Tho+`i dda.i ba^y
gio+`, vo+'i ky~ thua^.t transgenic, ho. la`m ddu? thu+' chuye^.n
ngu+o+.c la.i vo+'i thie^n nhie^n ...

=====
Tuan V Nguyen