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gnGenomeSpec.cpp

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// File:            gnGenomeSpec.cpp
// Purpose:         implements gnMultiSpec for genomes
// Description:     
// Changes:        
// Version:         libGenome 0.1.0 
// Author:          Aaron Darling 
// Last Edited:     April 15, 2001, 11:13:00pm 
// Modified by:     
// Copyright:       (c) Aaron Darling 
// Licenses:        Proprietary 

#include "gn/gnGenomeSpec.h"
#include <string>

gnGenomeSpec::gnGenomeSpec()
{
        Clear();
}

gnGenomeSpec::gnGenomeSpec( const gnGenomeSpec& s )
{
        m_sourceName = s.m_sourceName;
        m_name = s.m_name;
        m_reverseComplement = s.m_reverseComplement;
        m_circular = s.m_circular;
        //copy the header list.
        uint32 list_size =  s.m_headerList.size();
        m_headerList.reserve(list_size);
        for(uint32 i=0; i < list_size; i++)
                m_headerList.push_back(s.m_headerList[i]->Clone());
        //copy the fragment list.
        list_size =  s.m_SpecList.size();
        m_SpecList.reserve(list_size);
        for(uint32 i=0; i < list_size; i++)
                m_SpecList.push_back(s.m_SpecList[i]->Clone());
}
gnGenomeSpec::~gnGenomeSpec()
{
        Clear();
}
// Clone
void gnGenomeSpec::Clear()
{
        uint32 list_size =  m_SpecList.size();
        for(uint32 i=0; i < list_size; i++)
                delete m_SpecList[i];
        m_SpecList.clear();
        gnMultiSpec::Clear();
}

void gnGenomeSpec::SetReverseComplement( const boolean value )
{
        if(value == m_reverseComplement)
                return;
        //reverse the spec list entries
        vector<gnFragmentSpec*> tmp_spec_list;
        for(uint32 i=0; i < GetSpecListLength(); i++){
                //transmit rev_comp down to each fragment spec
                GetSpec(i)->SetReverseComplement(!GetSpec(i)->IsReverseComplement());
                tmp_spec_list.insert(tmp_spec_list.begin(), GetSpec(i));
        }
        m_SpecList = tmp_spec_list;
        m_reverseComplement = value;
}

gnGenomeSpec* gnGenomeSpec::CloneRange( const gnSeqI startI, const gnSeqI len ) const{
        if(len == 0)
                return new gnGenomeSpec();

        //find the valid range of specs to copy
        uint32 firstSpec = GetSpecIndexByBase(startI);
        gnSeqI total_copylen = len;
        uint32 endSpec;
        if(len != GNSEQI_END){
                endSpec = GetSpecIndexByBase(startI + len - 1);
        }else{
                endSpec = GetSpecListLength() - 1;
                total_copylen = GetLength() - startI;
        }

        //find their starting and ending bases
        gnSeqI firstBase = startI - GetSpecStartBase(firstSpec);
        gnSeqI firstSpecLen = GetSpec(firstSpec)->GetLength();
        boolean spans_specs = true;
        gnSeqI firstCopyLen = firstSpecLen - firstBase;
        if(firstCopyLen >= total_copylen){
                spans_specs = false;
                firstCopyLen = total_copylen;
        }
        
        gnGenomeSpec* destSpec = new gnGenomeSpec();
        gnFragmentSpec* newSpec = m_SpecList[firstSpec]->CloneRange(firstBase, firstCopyLen);
        destSpec->AddSpec( newSpec );

        gnSeqI cur_copylen = firstCopyLen;
        //add all the completely covered specs in the middle
        for(uint32 specI = firstSpec + 2; specI <= endSpec; specI++){
                destSpec->AddSpec(GetSpec(specI-1)->Clone());
                cur_copylen += GetSpec(specI-1)->GetLength();
        }
        //add the last spec if necessary
        if(spans_specs){
                newSpec = m_SpecList[endSpec]->CloneRange( 0, total_copylen - cur_copylen);
                destSpec->AddSpec(newSpec);
        }
        return destSpec;
}


//IMPLEMENT ME: What to do with headers?
void gnGenomeSpec::MergeFragments(const uint32 startF, const uint32 endF){
        if(startF > m_SpecList.size() || endF > m_SpecList.size())
                Throw_gnEx(FragmentIndexOutOfBounds());
        if(startF > endF)
                Throw_gnEx(FragmentIndexOutOfBounds());
        
        for(uint32 i = startF + 1; i < endF; i++){
                gnFragmentSpec* delspec = m_SpecList[startF + 1];
                m_SpecList.erase(m_SpecList.begin() + startF + 1);

                for(uint32 j = 0; j < delspec->GetSpecListLength(); j++)
                        m_SpecList[startF]->AddSpec(delspec->GetSpec(j));
                delete delspec;
        }
}

uint32 gnGenomeSpec::AddFeature( gnBaseFeature* feat ){
        uint32 count = 0;
        uint32 len = 0;
        uint32 featureI = 0;
        uint32 specListLen = GetSpecListLength();

        for(uint32 specI = 0; specI < specListLen; specI++){
                len = GetSpec(specI)->GetLength();
                gnLocation lt(count, count+len);
                if(feat->IsContainedBy(lt)){
                        return featureI + GetSpec(specI)->AddFeature(feat);
                }
                count += len;
                featureI += GetSpec(specI)->GetFeatureListLength();
        }
        //if we get this far then the feature has invalid coordinates
        Throw_gnEx(SeqIndexOutOfBounds());
}

uint32 gnGenomeSpec::GetFeatureListLength() const
{
        uint32 len = 0;
        for(uint32 i=0; i < GetSpecListLength(); i++)
                len += GetSpec(i)->GetFeatureListLength();
        return len;
}

gnBaseFeature* gnGenomeSpec::GetFeature(const uint32 i ) const
{
        uint32 count = 0;
        uint32 len = 0;
        for(uint32 specI=0; specI < GetSpecListLength(); specI++){
                len = GetSpec(specI)->GetFeatureListLength();
                if(count <= i && i < count + len){
                        gnBaseFeature* feat = GetSpec(specI)->GetFeature(i - count);
                        feat->MovePositive(GetSpecStartBase(specI));
                        return feat;
                }
                count += len;
        }
        Throw_gnEx(FeatureIndexOutOfBounds());
}

void gnGenomeSpec::GetContainedFeatures(const gnLocation& lt, vector<gnBaseFeature*>& feature_vector, vector<uint32>& index_vector) const{
        uint32 ss_size = GetSpecListLength();
        uint32 fl_size = 0;
        gnSeqI start_base = 0;
        for(uint32 i=0; i < ss_size; i++){
                gnLocation sub_lt = lt;
                gnSeqI sub_len = GetSpec(i)->GetLength();
                sub_lt.MoveNegative(start_base);
                sub_lt.CropEnd(sub_len);
                GetSpec(i)->GetContainedFeatures(sub_lt, feature_vector, index_vector);
                uint32 fvs = feature_vector.size();
                for(uint32 j = 0; j < fvs; j++){
                        feature_vector[j]->MovePositive(start_base);
                        index_vector[j]+= fl_size;
                }
                if(fvs > 0)
                        return;
                start_base += sub_len;
                fl_size += GetSpec(i)->GetFeatureListLength();
        }
}

void gnGenomeSpec::GetIntersectingFeatures(const gnLocation& lt, vector<gnBaseFeature*>& feature_vector, vector<uint32>& index_vector) const{
        uint32 ss_size = GetSpecListLength();
        uint32 fl_size = 0;
        gnSeqI start_base = 0;
        for(uint32 i=0; i < ss_size; i++){
                gnLocation sub_lt = lt;
                gnSeqI sub_len = GetSpec(i)->GetLength();
                sub_lt.MoveNegative(start_base);
                sub_lt.CropEnd(sub_len);
                GetSpec(i)->GetIntersectingFeatures(sub_lt, feature_vector, index_vector);
                uint32 fvs = feature_vector.size();
                for(uint32 j = 0; j < fvs; j++){
                        feature_vector[j]->MovePositive(start_base);
                        index_vector[j]+= fl_size;
                }
                if(fvs > 0)
                        return;
                start_base += sub_len;
                fl_size += GetSpec(i)->GetFeatureListLength();
        }
}
void gnGenomeSpec::GetBrokenFeatures(const gnLocation& lt, vector<gnBaseFeature*>& feature_vector) const{
        uint32 ss_size = GetSpecListLength();
        uint32 fl_size = 0;
        gnSeqI start_base = 0;
        for(uint32 i=0; i < ss_size; i++){
                gnLocation sub_lt = lt;
                gnSeqI sub_len = GetSpec(i)->GetLength();
                sub_lt.MoveNegative(start_base);
                sub_lt.CropEnd(sub_len);
                GetSpec(i)->GetBrokenFeatures(sub_lt, feature_vector);
                uint32 fvs = feature_vector.size();
                for(uint32 j = 0; j < fvs; j++)
                        feature_vector[j]->MovePositive(start_base);
                if(fvs > 0)
                        return;
                start_base += sub_len;
                fl_size += GetSpec(i)->GetFeatureListLength();
        }
}

void gnGenomeSpec::RemoveFeature( const uint32 i ){
        uint32 count = 0;
        uint32 len = 0;
        uint32 specI=0;
        for(; specI < GetSpecListLength(); specI++){
                len = GetSpec(specI)->GetFeatureListLength();
                if(count <= i && i < count + len){
                        GetSpec(specI)->RemoveFeature( i - count);
                }
                count += len;
        }
        Throw_gnEx(FeatureIndexOutOfBounds());
}

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