Selected References on Gene Mapping for Experimental Crosses

• gene mapping in a biological context
  • Mackay TFC (2001a) The genetic architecture of quantitative traits. Annu. Rev. Genet. 35: 303-339. [Paper]
• statistical issues for QTL
  • Broman KW (2001) Review of statistical methods for QTL mapping in experimental crosses. Lab Animal 30(7): 44-52. [Paper]
  • Doerge RW, Zeng ZB, Weir BS (1997) Statistical issues in the search for genes affecting quantitative traits in experimental populations. Statist Sci 12: 195-219.
• comparison of QTL methods
  • Churchill GA, Doerge RW (1994) Empirical threshold values for quantitative trait mapping. Genetics 138: 963-971. [Paper]
  • Sen S, Churchill GA (2001) A statistical framework for quantitative trait mapping. Genetics 159: 371-387. [Paper | Software]
  • Yandell BS, Bradbury P (2007) Computing strategies and software for gene mapping. Ch. 11, Principles & Practices of Plant Molecular Mapping & Breeding. Ed. by C Kole. Springer-Verlag (to appear). [Paper]
• from QTL to gene
  • Glazier AM, Nadeau JH, Aitman TJ (2002) Finding genes that underlie complex traits. Science 298: 2345-2349. [Paper]
  • Guo SW, Lange K (2000) Genetic mapping of complex traits: promises, problems, and prospects. Theor Pop Biol 57: 1-11. [Paper]
  • Page GF, George V, Go RC, Page PZ, Allison DB (2003) "Are we there yet?": Deciding when one has demonstrated specific genetic causation in complex diseases and quantitative traits. Am J Hum Gen 73: 711-719. [Paper]