Ca^y thuo^'c, patent, ethical issues

[Tuan V Nguyen <t.nguyen@garvan.unsw.edu.au>]

Cha`o ca'c ba'c,

> To^i ddo^`ng y' vo*'i ba'c Tua^'n(Australia) la` ne^'u la` du*o*.c 
>tha?o thi` ta pha?i la^'y Patent mo*'i ddu*o*.c . La^u ro^`i to^i co' 
>ddo.c mo^.t ba`i ba'o no'i ve^` nhu*~ng nghie^n cu*'u ve^` ca'c loa.i 
>tha?o du*o*.c, sau khi tha`nh co^ng; co' sa?n pha^?m ba'n ra thi. 
>tru*o*`ng; Ca'c Co^ng ty A^u My~ ho^'y ba.c ty? ddo^ la co`n ca'c ba'c 
>da^n ddia. phu*o*ng ba(ng ru*`ng lo^.i suo^'i ti`m ca^y thuo^'c trong 
>kho ta`ng da^n du*o*.c cu?a mi`nh thi` chi? ddu*o*.c chia pha^`n co^ng 
>kho?ang 100 ddo^ la !!!!!!!

	Chuye^.n na`y dda~ xa?y ra nhie^`u ro^`i. To^i tha^'y 
y' kie^'n cu?a chi. DQ quan tro.ng. Muo^'n la`m gi` thi` 
la`m, ma^'y ba'c be^n VN ca^`n pha?i very careful vo+'i ma^'y 
anh cowboy na`y mo+'i ddu+o+.c. Coi chu+`ng ma^'y a?nh mang 
tie^`n va`o ro^`i hijack ca'i project la` ca'c ba'c ddo' 
cha(?ng co' credit gi` ra'o tro.i. Coi chu+`ng.

	Vie^.n cu?a to^i dda~ mo^.t la^`n ra toa` vo+'i mo^.t 
co^ng ty du+o+.c kho^?ng lo^` cu?a My~ cu~ng vi` vu. na`y. 
Ho. va`o va` tung tie^`n cho mi`nh la`m, xong ho. mang ddi 
dda(ng ky' patent ho^`i na`o cha(?ng ai hay, khi hay ra thi` 
dda~ muo^.n. Chuye^.n phu+'c ta.p la('m va` chu+a nga~ ngu? 
gi` ca?. 


>To^i sa(~n sa`ng trao ddo^?i y' kie^'n vo*'i ca'c ba'c be^n nha` ve^` 
>nhu*~ng tho^ng tin lie^n he^. dde^'n va^'n dde^` processing and 
>development a drug dde^? ba?o ve^. quye^`n lo*i. cho VN. 

	Mi`nh la` nhu+~ng ngu+o+`i co' kinh nghie^.m chuye^.n 
na`y cho ne^n ca^`n pha?i ma'ch cho ca'c ba'c be^n VN. Va` 
to^i hoan nghe^nh chi. DQ trong vie^.c na`y.

> Ba'c Tua^'n, ne^'u qua? tha^.t la` "tha^`n du*o*.c" thi` $400,000 dda^u 
>co' lo*'n! Tuy la` lo*'n ddo^'i vo*'i grant nghie^n cu*'u. 

	Tro+`i o+i, to^i dda~ ba la^`n xin tie^`n NIH va` chi? 
tha`nh co^ng co' mo^.t la^`n va` so^' tie^`n chi? ba(`ng so^' 
le~ cu?a 400K, ne^n to^i tha^'y la` mu+`ng ro^`i :). Nhu+ng 
nhu+ chi. no'i ddo', ne^'u la` wonder drug thi` so^' tie^`n 
na`y cha(?ng la` bao nhie^u.


	Mo^.t ddie^`u ca^`n chu' y' nu+~a la` ne^'u muo^'n 
ho+.p ddo^`ng vo+'i ca'c co^ng ty du+o+.c dde^? sa?n xua^'t 
ha`ng loa.t (mass production) thi` pha?i qua clinical trials, 
FDA (food drug agency - "hung tha^`n" cu?a ca'c co^ng ty 
du+o+.c) phie^`n phu+'c va` to^'n ke'm la('m, chu+' kho^ng 
ddo+n gia?n nhu+ ca'c ba'c be^n VN tu+o+?ng dda^u. 

	Ta^'t ca? ca'c thu+? nghie^.m pha?i qua:

	(a) animal study tru+o+'c he^'t
	(b) dose-response study dde^? ti`m ra ca'i optimal dose
	(c) ro^`i mo+'i to+'i thu+? nghie^.m tre^n con ngu+o+`i

va` ngay ca? muo^'n thu+? nghie^.m tre^n human, ca^`n pha?i 
la`m theo ddie^`u le^. cu?a The Helsinki Declaration 1969 
ha(?n ho`i, va` be^.nh nha^n pha?i ky' te^n ddo^`ng y' va` 
co' ngu+o+`i la`m ba(`ng chu+'ng. Cuo^.c thu+? nghie^.m pha?i 
ddu+o+.c design va` ti'nh toa'n tru+o+'c, pha?i ddu+o+.c 
mo^.t ho^.i ddo^`ng ethics cho phe'p (kho^ng bie^'t be^n VN 
ta co' ethics committee kho^ng nhi?). So^' lie^.u thu tha^.p 
trong thu+? nghie^.m pha?i ddu+o+.c pha^n ti'ch properly va` 
publish cho international community bie^'t.

	To^i tha^'y ca'c ba'c be^n VN la`m "ba.o" qua'. Nhu+~ng 
thu+? nghie^.m ma` to^i ddo.c ddu+o+.c tre^n ba'o, ne^'u dda~ 
xa?y ra tha^.t (ma` to^i tin la` va^.y) thi` pha?i no'i la` 
kho^ng ddu+o+.c ETHICAL ma^'y. DDa^u pha?i muo^'n thu+? 
thuo^'c cho ai la` la`m de^~ da`ng nhu+ va^.y ddu+o+.c.

	To^i co`n nho+' lu'c to^i co`n la`m cho trung ta^m 
Clinical Research o+? Basle, loa.i thuo^'c Cyclosporin 
(Sandimun) la` loa.i thuo^'c du`ng cho organ transplantation, 
pha?i ma^'t ngo't 20 na(m tu+` lu'c kha'm pha' cho to+'i 
marketing!

	DDu+o+`ng co`n da`i dde^? ho^'t ba.c trie^.u!

	Tua^'n